A5016505439- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Electrochemical Analysis and Applications
- Nanoparticle-Based Drug Delivery
- Nail Diseases and Treatments
- Research on Leishmaniasis Studies
- Phytochemistry Medicinal Plant Applications
- Insect Pest Control Strategies
- Conducting polymers and applications
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Antifungal resistance and susceptibility
- Bee Products Chemical Analysis
- Photochromic and Fluorescence Chemistry
- Advancements in Transdermal Drug Delivery
- Organic Chemistry Cycloaddition Reactions
- Electrochemical sensors and biosensors
- Fungal Infections and Studies
- Advanced Chemical Sensor Technologies
- Curcumin's Biomedical Applications
- Mass Spectrometry Techniques and Applications
- Cardiovascular Conditions and Treatments
Universidade Federal do Maranhão
2022-2025
Universidade Estadual de Maringá
2017-2024
Exact Sciences (United States)
2024
Universidade Estadual Paulista (Unesp)
2009-2020
Universidade Federal do Rio Grande do Sul
2005-2013
Universidade Federal de Santa Maria
1985-1996
Universidade de São Paulo
1982-1985
Cutaneous leishmaniasis caused by Leishmania amazonensis is a significant public health issue. This study aimed to evaluate an ecofriendly, thermosensitive nanogel, developed using low-energy, solvent-free method, incorporating F127 and Carbopol 974P copolymers, enriched with Pectis brevipedunculata essential oil (EOPb) for its leishmanicidal anti-inflammatory properties. The nanogel was prepared characterized through FTIR, DLS, SEM, AFM confirm the incorporation of EOPb as well stability...
Nanocarriers have been successfully used to solubilize, deliver, and increase the bioavailability of curcumin (CUR), but slow CUR release rates hinder its use as a topical photosensitizer in antimicrobial photodynamic therapy. A photo-responsive polymer (PRP) was designed for light-triggered with an effective light activation-dependent response. The characterization PRP compared non-responsive micelles comprising Pluronics™ P123 F127. According findings, formed nanometric scale (< 100 nm)...
According to the literature, methylene blue (MB) is a photosensitizer (PS) with high affinity for mitochondria. Therefore, several studies have explored this feature evaluate its photodynamic effects on mitochondrial apoptotic pathway under normoxic conditions. We are aware only of limited reports regarding MB's energy metabolism, especially hypoxic Thus, purposes study were determine direct and acute MB metabolism rat liver mitochondria conditions parameters linked in isolated perfused...
Aim: To evaluate the efficacy of photodynamic inactivation (PDI) mediated by hypericin encapsulated in P-123 copolymeric micelles (P123-Hyp) alone and combination with fluconazole (FLU) against planktonic cells biofilm formation Candida species Materials & methods: PDI was performed using P123-Hyp an LED device irradiance 3.0 mW/cm2 . Results: Most isolates (70%) were completely inhibited concentrations up to 2.0 μmol/l HYP light fluence 16.2 J/cm2. FLU-resistant strains had synergic effect...
Infectious and Parasitic Diseases (IPD) remain a challenge for medicine due to several interconnected reasons, such as antimicrobial resistance (AMR). American tegumentary leishmaniasis (ATL) is an overlooked IPD causing persistent skin ulcers that are challenging heal, resulting in disfiguring scars. Moreover, it has the potential extend from mucous membranes of nose, mouth, throat both humans various animals. Given limited effectiveness AMR current drugs, exploration new substances emerged...
Different from works described in the literature, which use expansive analytical methods to separation of anthraquinones derivatives (AQs), this communication reported a simple and inexpensive methodology get them. In way, expensive commercial AQs: Chrysophanol, physcione emodine were extracted plant material (Rhamnus frangula L.) isolated by classical column chromatography technique under optimised binary mobile phase gradients (CHCl3 : AcOEt(a), = 1 5%) excellent yields.
Background/Objectives: Neglected tropical diseases (NTDs), such as leishmaniasis, remain a global health challenge due to limited therapeutic options and rising drug resistance. In this study, we developed an advanced nanogel formulation incorporating curcumin (CUR) Pectis brevipedunculata essential oil (EOPb) within F127/Carbopol 974P matrix enhance bioavailability efficacy against Leishmania (Leishmania) amazonensis (LLa) promastigotes. Methods: The chemical profile of EOPb was determined...
The antioxidant capacity of essential oils Mentha spicata L., x gentilis crispa piperita L. and was determined by using differential pulse voltammetry. This assay based on the reduction in limiting current value oxygen electroreduction, which used to calculate (K) these species. species M. had highest K value. Cyclic voltammetry experiments confirmed interaction between electrode surface active compounds present oils. A simple electrochemical method for determining ability chelate Fe (II) is...
In this work, an improved synthesis process was developed for the multigram production of hypericin. An inexpensive and efficient low power Light Emission Diode (LED) based photoreactor designed employed to perform protohypericin photocyclization reaction allowing its photoconversion in This closed system overcomes safety issues related scale-up hypericin preparation typically described literature which combines use open systems, organic solvents, high-power light sources. The allows a...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPREPARATION OF THIOPHANTHRENEQUINONE AND ITS DERIVATIVES.1 IRENATO GONCALVES and ELLIS V. BROWNCite this: J. Org. Chem. 1952, 17, 5, 698–704Publication Date (Print):May 1, 1952Publication History Published online1 May 2002Published inissue 1 1952https://pubs.acs.org/doi/10.1021/jo01139a007https://doi.org/10.1021/jo01139a007research-articleACS PublicationsRequest reuse permissionsArticle Views252Altmetric-Citations17LEARN ABOUT THESE METRICSArticle...
Background: Breast cancer is the most relevant type of and second cause cancer- related deaths among women in general. Currently, there no effective treatment for breast although advances its initial diagnosis are available. Therefore, value novel anti-tumor therapeutic modalities remains an immediate unmet need clinical practice. Following our previous work regarding properties Pluronics with different photosensitizers (PS) photodynamic therapy (PDT), this study we aimed to evaluate...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPREPARATION OF THIOPHANTHRENEQUINONES. II. THENOYLNITROBENZOIC ACIDS AND NITROTHIOPHANTHRENEQUINONES1RENATO GONCALVES, MATTHEW R. KEGELMAN, and ELLIS V. BROWNCite this: J. Org. Chem. 1952, 17, 5, 705–712Publication Date (Print):May 1, 1952Publication History Published online1 May 2002Published inissue 1 1952https://pubs.acs.org/doi/10.1021/jo01139a008https://doi.org/10.1021/jo01139a008research-articleACS PublicationsRequest reuse permissionsArticle...
Objective: Breast cancer (BC) currently has no effective treatment especially for the highly aggressive and metastatic triple negative breast (TNBC). Here, we investigated antitumoral antimigratory effects of hypericin (HYP) encapsulated on Pluronic F127 (F127/HYP) photodynamic therapy (PDT) against TNBC cell line MDA-MB-231 compared to a nontumorigenic human ductal (MCF-10A). Methods: The phototoxicity/cytotoxicity was assessed by MTT assay, long-term cytotoxicity clonogenic uptake,...