A5083398394- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Synthesis and biological activity
- Plant Pathogens and Fungal Diseases
- Reproductive tract infections research
- Synthesis and Biological Evaluation
- Plant-Microbe Interactions and Immunity
- Redox biology and oxidative stress
- Bee Products Chemical Analysis
- Biochemical and Molecular Research
- Photodynamic Therapy Research Studies
- Phytochemical compounds biological activities
- Click Chemistry and Applications
- Mycotoxins in Agriculture and Food
- Phytochemistry and Biological Activities
- Enzyme Structure and Function
- Fungal Biology and Applications
- Infectious Diseases and Mycology
- Medical and Biological Ozone Research
- Essential Oils and Antimicrobial Activity
- Antimicrobial Peptides and Activities
- Heat shock proteins research
- Microbial Metabolism and Applications
- Probiotics and Fermented Foods
Universidade Estadual de Maringá
2015-2025
Universidade de Brasília
2011-2014
University of Lausanne
2012
Universidade Federal de São Paulo
2009-2012
The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent a major ongoing zoonotic outbreak sporotrichosis in Brazil. Elsewhere, sapronoses are caused by schenckii and globosa. aims on this comparative genomic study are: 1) to explore presence virulence factors brasiliensis; 2) compare which cat-transmitted infects both humans cats with schenckii, mainly pathogen; 3) two species other pathogens (Onygenales) similar...
Concerns over the replicability and reproducibility of published research have grown in many fields, but empirical data to inform policies are still scarce. Biomedical Brazil expanded rapidly last three decades, with no systematic assessment its findings. With this mind, we set up Brazilian Reproducibility Initiative, a multicenter replication experiments from science using common experimental methods: MTT assay, reverse transcription polymerase chain reaction (RT-PCR) elevated plus maze...
The prevalence of invasive fungal infections (IFIs) has increased steadily worldwide in the last few decades. Particularly, there been a global rise number among immunosuppressed people. These patients present severe clinical forms infections, which are commonly fatal, and they more susceptible to opportunistic than non-immunocompromised IFIs have historically associated with high morbidity mortality, partly because limitations available antifungal therapies, including side effects,...
The present study evaluated the capacity of three species Fusarium isolated from onychomycosis to form biofilms and antibiofilm effect propolis extract on these biofilms.The effects were by quantifying colony-forming units, mitochondrial metabolic activity assays, total biomass crystal violet staining scanning electron microscopy.Propolis demonstrated significant efficiency spp. isolates reduced F. solani, oxysporum subglutinans mature biofilms.Propolis can be an alternative topical treatment caused
Aim: To evaluate the efficacy of photodynamic inactivation (PDI) mediated by hypericin encapsulated in P-123 copolymeric micelles (P123-Hyp) alone and combination with fluconazole (FLU) against planktonic cells biofilm formation Candida species Materials & methods: PDI was performed using P123-Hyp an LED device irradiance 3.0 mW/cm2 . Results: Most isolates (70%) were completely inhibited concentrations up to 2.0 μmol/l HYP light fluence 16.2 J/cm2. FLU-resistant strains had synergic effect...
Paracoccidioidomycosis (PCM), caused by Paracoccidioides , is a systemic mycosis with granulomatous character and restricted therapeutic arsenal. The aim of this work was to search for new alternatives treat largely neglected tropical mycosis, such as PCM.
The prevalence of invasive fungal infections worldwide has increased in the last decades. development specific drugs targeting pathogenic fungi without producing collateral damage to mammalian cells is a daunting pharmacological challenge. Indeed, many toxicities and drug interactions observed with contemporary antifungal therapies can be attributed "nonselective" enzymes or cell membrane systems found host cells. A computer-aided screening strategy against TRR1 protein Paracoccidioides...
The search for new drugs to treat tuberculosis and nontuberculous mycobacteria-caused diseases is still desired. This the first study aimed at determining activity of two innovative synthetic 1,3,4-oxadiazole molecules, (4-[cyclohexyl(ethyl) sulfamoyl]-N-[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]benzamide)), namely LMM11, ((N-cyclo-hexyl-N-ethylsulfamoil)-N-(5- (4-fluorophenyl)-1,3,4-oxadiazol-2-il) benzamide), LMM6, against Mycobacterium mycobacteria, their ability present synergism in when...
In the search to reduce side effects, toxicity and assuring desired effectiveness of drugs, many efforts has been made improve specific drugs’ delivery characteristics. Several carrier nanoparticles have used assist drugs incorporation, absorption transport through bloodstream. However, most chemical synthesis routes are multistep time-consuming treatments and, also, toxic effects. this work, we report a simple one-pot approach for CoFe 2 O 4 (20 100 nm). The magnetic measurements revealed...
Candida infections have become a serious public health problem with high mortality rates, especially in immunocompromised patients, being albicans the major opportunistic pathogen responsible for systemic or invasive candidiasis. Commercially available antifungal agents are restricted and fungal resistance to such drugs has increased; therefore, development of more specific is necessary. Using assays activity, here we report that two new compounds 1,3,4-oxadiazoles class (LMM5 LMM11), which...
Vulvovaginal candidiasis (VVC) is a common vaginitis that affects women, especially in childbearing age, caused by Candida albicans almost 80% of cases. Considering the limited drug arsenal available and increasing fungal resistance profile, search for new therapeutic sources with low toxicity easy administration should be supported. Propolis has been used as traditional medicine multiple diseases, considering its particular composition pharmaceutical properties permits wide applicability;...
Aim: 17 new 4-methoxynaphthalene-N-acylhydrazones were synthesized in order to evaluate their biological action against important pathogens. Methods: In vitro susceptibility assays of compounds performed Paracoccidioides brasiliensis and Mycobacterium tuberculosis. Results: Compounds 4a, 4b 4k the most potent P. brasiliensis, two with minimum inhibitory concentrations ≤1 μg ml-1 exhibited pharmacological synergy amphotericin B. The also showed activity M. tuberculosis, 4c being more...
Paracoccidioidomycosis (PCM) is a neglected disease present in Latin America with difficulty treatment and occurrence of serious sequelae. Thus, the development alternative therapies imperative. In current work, two oxadiazole compounds (LMM5 LMM11) presented fungicidal activity against Paracoccidioides spp. The minimum inhibitory concentration values ranged from 1 to 32 μg/mL, synergic effect was observed for both when combined Amphotericin B. LMM5 LMM11 were able reduce CFU counts (≥2...