A5044275719- Wnt/β-catenin signaling in development and cancer
- Connective Tissue Growth Factor Research
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Axon Guidance and Neuronal Signaling
- TGF-β signaling in diseases
- Proteoglycans and glycosaminoglycans research
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Adenosine and Purinergic Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Sphingolipid Metabolism and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related Molecular Pathways
- Nutrition, Genetics, and Disease
- Adipose Tissue and Metabolism
- Calcium signaling and nucleotide metabolism
- Receptor Mechanisms and Signaling
- Cellular Mechanics and Interactions
- Genetic and Environmental Crop Studies
- Sirtuins and Resveratrol in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
Universidade Federal do Rio de Janeiro
2014-2025
Nepal Development Research Institute
2014
University of California, Los Angeles
2009
Minhaj University Lahore
2006
Departamento de Ciência e Tecnologia
2001
The amyloid-β peptide (Aβ) plays a major role in neuronal dysfunction and neurotoxicity Alzheimer disease. However, the signal transduction mechanisms involved Aβ-induced remain to be fully elucidated. A current unknown is identity of protein receptor(s) Aβ binding. Using phage display libraries, we have identified number peptides that bind are homologous receptors putatively interactions. We report here on cysteine-linked cyclic heptapeptide (denominated cSP5) binds with high affinity...
Concerns over the replicability and reproducibility of published research have grown in many fields, but empirical data to inform policies are still scarce. Biomedical Brazil expanded rapidly last three decades, with no systematic assessment its findings. With this mind, we set up Brazilian Reproducibility Initiative, a multicenter replication experiments from science using common experimental methods: MTT assay, reverse transcription polymerase chain reaction (RT-PCR) elevated plus maze...
Flavonoids are plant-derived polyphenolic molecules that have potential biological effects including anti-oxidative, anti-inflammatory, anti-viral, and anti-tumoral effects. These related to the ability of flavonoids modulate signaling pathways, such as canonical Wnt pathway. This pathway controls many aspects embryonic development tissue maintenance has been found be deregulated in a range human cancers. We performed several vivo assays Xenopus embryos, functional model studies, also used...
More than 94% of colorectal cancer cases have mutations in one or more Wnt/β-catenin signaling pathway components. Inactivating APC activating β-catenin (CTNNB1) lead to overactivation and subsequent intestinal hyperplasia. Numerous classes medicines derived from synthetic natural small molecules, including alkaloids, benefited the treatment different diseases, cancer, Piperine is a true alkaloid, lysine, responsible for spicy taste black pepper (Piper nigrum) long longum). Studies shown...
The deregulation of the Wnt/β-catenin signaling pathway is a central event in colorectal cancer progression, thus promising target for drug development. Many natural compounds, such as flavonoids, have been described inhibitors and consequently modulate important biological processes like inflammation, redox balance, promotion progress, well cell death. In this context, we identified chalcone lonchocarpin isolated from Lonchocarpus sericeus inhibitor, both vitro vivo. Lonchocarpin impairs...
Glioblastomas (GBMs) are highly aggressive primary brain tumors characterized by cellular heterogeneity, insensitivity to chemotherapy and poor patient survival. Lysophosphatidic acid (LPA) is a lysophospholipid that acts as bioactive signaling molecule plays important roles in diverse biological events during development disease, including several cancer types. Microglial cells, the resident macrophages of central nervous system, express high levels Autotaxin (ATX,Enpp2), an enzyme...
Connective-tissue growth factor (CTGF) is a modular secreted protein implicated in multiple cellular events such as chondrogenesis, skeletogenesis, angiogenesis and wound healing. CTGF contains four different structural modules. This organization characteristic of members the CCN family. The acronym was derived from first three discovered, cysteine-rich 61 (CYR61), nephroblastoma overexpressed (NOV). mediator important cell processes adhesion, migration, proliferation differentiation....
Overactivation of the Wnt/β-catenin pathway in adult tissues has been implicated many diseases, such as colorectal cancer. Finding chemical substances that can prevent this phenomenon is an emerging problem. Recently, several natural compounds have described inhibitors and might be promising agents for control carcinogenesis. Here, we describe two substances, derricin derricidin, belonging to chalcone subclass, show potent transcriptional inhibition pathway. Both chalcones are able affect...
Background/Objectives: The low permeability of the blood-brain barrier (BBB) represents a significant challenge to effective systemic chemotherapy for primary and metastatic brain cancers. Kinin receptors play crucial role in modulating BBB permeability, their agonist analogs have been explored preclinical animal models enhance drug delivery brain. In this study, we investigated whether des-Arg9-bradykinin (DBK), physiological kinin B1 receptor (B1R), acts as adjuvant by promoting transient...
In Xenopus embryos, a dorsal-ventral patterning gradient is generated by diffusing Chordin/bone morphogenetic protein (BMP) complexes cleaved BMP1/Tolloid metalloproteinases in the ventral side. We developed new assay using fluorogenic Chordin peptide substrate and identified an unexpected negative feedback loop for BMP4, which BMP4 inhibits Tolloid enzyme activity noncompetitively. binds directly to CUB (Complement 1r/s, Uegf [a sea urchin embryonic protein] BMP1) domains of BMP1 Drosophila...
The Wnt/β-catenin signaling pathway dictates cell proliferation and differentiation during embryonic development tissue homeostasis. Its deregulation is associated with many pathological conditions, including neurodegenerative disease, frequently downregulated. lack of efficient treatment for these diseases, Alzheimer's disease (AD), makes Wnt an attractive target therapies. Interestingly, novel activating compounds are less described than inhibitors, turning the quest positive modulators...
Maternal Wnt/β-Catenin signaling is essential to establish dorsal-specific gene expression required for axial patterning in Xenopus. Deregulation of this pathway causes axis phenotypes frog embryos. In adult life, mutations the Wnt components are associated with many diseases, such as polyposis coli; osteoporosis-pseudoglioma syndrome (OPPG); skeletal dysplasia; neural tube defects, cancer and others. Thus, a better understanding Wnt/β-catenin will have great significant impact on Biology...
Radial glial cells and astrocytes are heterogeneous with respect to morphology, cytoskeletal- membrane-associated molecules intercellular interactions. Astrocytes derived from lateral (L) medial (M) midbrain sectors differ in their abilities support neuritic growth of neurons coculture (Garcia-Abreu et al. J Neurosci Res 40:471, 1995). There is a correlation between these the differential patterns laminin (LN) organization that fibrillar growth-permissive L punctate non-permissive M...
The blood–brain barrier (BBB) is a highly intricate neurovascular structure that plays crucial role in maintaining neural homeostasis by selectively allowing certain molecules to enter the central nervous system (CNS). However, context of Alzheimer’s Disease (AD), progressive neurodegenerative disorder characterized gradual decline cognitive function, BBB’s functionality becomes impaired. This impairment leads breakdown and disrupts its ability regulate molecular transport effectively....
Connective-tissue growth factor (CTGF/CCN2) is a matricellular-secreted protein involved in complex processes such as wound healing, angiogenesis, fibrosis and metastasis, the regulation of cell proliferation, migration extracellular matrix remodeling. Glioblastoma (GBM) major malignant primary brain tumor its adaptation to central nervous system microenvironment requires production remodeling matrix. Previously, we published an vitro approach test if neurons can influence expression GBM We...