A5010356710- Meta-analysis and systematic reviews
- Academic Publishing and Open Access
- Animal testing and alternatives
- scientometrics and bibliometrics research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Research Data Management Practices
- Viral Infectious Diseases and Gene Expression in Insects
- Digital and Traditional Archives Management
- Biomedical and Engineering Education
- Delphi Technique in Research
- Neuroscience and Neuropharmacology Research
- Molecular Biology Techniques and Applications
- FinTech, Crowdfunding, Digital Finance
- Biochemical Acid Research Studies
- Academic integrity and plagiarism
- Medicinal Plants and Neuroprotection
- Statistical Methods in Clinical Trials
- Computational and Text Analysis Methods
- Career Development and Diversity
- Conferences and Exhibitions Management
- Health Systems, Economic Evaluations, Quality of Life
- Machine Learning and Data Classification
- Academic Writing and Publishing
Universidade Federal do Rio de Janeiro
2015-2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022-2023
Preprint usage is growing rapidly in the life sciences; however, questions remain on relative quality of preprints when compared to published articles. An objective dimension that readily measurable completeness reporting, as transparency can improve reader's ability independently interpret data and reproduce findings.
Early career researchers (ECRs) are important stakeholders leading efforts to catalyze systemic change in research culture and practice. Here, we summarize the outputs from a virtual unconventional conference (unconference), which brought together 54 invited experts 20 countries with extensive experience ECR initiatives designed improve practice of science. Together, drafted 2 sets recommendations for (1) ECRs directly involved or activities practice; (2) who wish support these efforts....
Concerns over the replicability and reproducibility of published research have grown in many fields, but empirical data to inform policies are still scarce. Biomedical Brazil expanded rapidly last three decades, with no systematic assessment its findings. With this mind, we set up Brazilian Reproducibility Initiative, a multicenter replication experiments from science using common experimental methods: MTT assay, reverse transcription polymerase chain reaction (RT-PCR) elevated plus maze...
Most efforts to estimate the reproducibility of published findings have focused on specific areas research, even though science is usually assessed and funded a regional or national basis. Here we describe project assess in biomedical by researchers based Brazil. The Brazilian Reproducibility Initiative systematic, multicenter effort repeat between 60 100 experiments: will focus set common methods, repeating each experiment three different laboratories from countrywide network. results, due...
Over the past decade, open science movement has transformed research landscape, though its impact largely been confined to developed countries. Recently, researchers from developing countries have called for a redesign of better align with their unique contexts. However, raising awareness alone is insufficient—practical actions are required drive meaningful and inclusive change. In this work, we analyze opportunities offered by explore macro- micro-level barriers in face when engaging these...
Preprints have been increasingly used in biomedical science, and a key feature of many platforms is public commenting. The content these comments, however, has not well studied, it unclear whether they resemble those found journal peer review.To describe the comments on bioRxiv medRxiv preprint platforms.In this cross-sectional study, preprints posted 2020 were accessed through each platform's application programming interface March 29, 2021, random sample containing between 1 20 was...
Memory extinction involves the formation of a new associative memory that inhibits previously conditioned association. Nonetheless, it could also depend on weakening original trace if is assumed to have multiple components. The phosphatase calcineurin (CaN) has been described as being involved in but not initial consolidation fear learning. With this mind, we set study whether CaN different roles distinct components extinction. Systemic treatment with inhibitors cyclosporin A (CsA) or...
Abstract Background Preprint usage is growing rapidly in the life sciences; however, questions remain on relative quality of preprints when compared to published articles. An objective dimension that readily measurable completeness reporting, as transparency can improve reader’s ability independently interpret data and reproduce findings. Methods In this observational study, we initially independent samples articles bioRxiv PubMed-indexed journals 2016 using a reporting questionnaire. After...
Abstract Introduction Preprints have been increasingly used in biomedical sciences, providing the opportunity for research to be publicly assessed before journal publication. With increase attention over preprints during COVID-19 pandemic, we decided assess content of comments left on preprint platforms. Methods posted bioRxiv and medRxiv 2020 were accessed through each platform’s API, a random sample that had received between 1 20 was analyzed. Comments evaluated triplicate by independent...
Systematic reviews and meta-analyses have been increasingly recognized for their potential value in pre-clinical research, but applications not extensively explored behavioral neuroscience. In this work, we studied protein synthesis inhibition, a classic intervention used to disrupt fear learning, reconsolidation, extinction rodents, explore how can identify moderators of its effect. We initially performed separate different injection sites target sessions evaluate the effect various...
Scientists have increasingly recognised that low methodological and analytical rigour combined with publish-or-perish incentives can make the published scientific literature unreliable. As a response to this, large-scale systematic replications of emerged as way assess problem empirically. The Brazilian Reproducibility Initiative is one such effort, aimed at estimating reproducibility biomedical research. Its goal perform multicentre quasi-random sample least 60 experiments from articles...
Confirmatory multi-lab preclinical trials are a powerful experimental strategy to enable decisions transition from clinical settings. With their complexity, such study designs pose several challenges in analysing and reporting experiments. To address these, we convened an expert group of biostatisticians biomedical scientists currently involved summarise the most common scenarios. Furthermore, incorporated statistical advice existing trials’ guidelines adapted it into recommendations for...
The scholarly publishing system is adapting to many changes including open access and data mandates, new technologies, artificial intelligence. Members of the research communities are working establish a more equitable, fair, rigorous that serves researchers’ evolving needs. Early career researchers (ECRs) drivers change, publishers may wonder why how they should involve ECRs in shaping future publishing. We held virtual unconference explore this issue with who were improve Some participants...
Confirmatory multi-lab preclinical trials are a powerful experimental strategy to enable decisions transition from clinical settings. With their complexity, such study designs pose several challenges in analysing and reporting experiments. To address these, we convened an expert group of biostatisticians biomedical scientists currently involved summarise the most common scenarios. Furthermore, incorporated statistical advice existing trials’ guidelines adapted it into recommendations for...
Early career researchers (ECRs) are important stakeholders leading efforts to catalyze systemic change in the conduct and communication of science. Here, we summarize outputs from a virtual unconventional conference (unconference), which brought together 54 invited experts 20 countries with extensive experience ECR initiatives designed improve The event was focused on why ECRs needed science obstacles they face when trying promote reform. Our discussions also highlighted additional that...
Scientists have increasingly recognized that low methodological and analytical rigor combined with publish-or-perish incentives can make the published scientific literature unreliable. As a response to this, large-scale systematic replications of emerged as way assess problem empirically. The Brazilian Reproducibility Initiative is one such effort, aimed at estimating reproducibility biomedical research. Its goal perform multicenter quasi-random sample least 60 experiments from articles over...
Introduction: Translation is about successfully bringing findings from preclinical contexts into the clinic. This transfer challenging as clinical trials frequently fail despite positive results. Limited robustness of research has been marked one drivers such failures. One suggested solution to improve external validity in vitro and vivo experiments via a suite complementary strategies.Areas covered: In this review, we summarize literature available on different strategies validity:...
With concerns over research reproducibility on the rise, systematic replications of published science have become an important tool to estimate replicability findings in specific areas. Nevertheless, such initiatives are still uncommon biomedical science, and never been performed at a national level. The Brazilian Reproducibility Initiative is multicenter, effort assess country’s by replicating between 60 100 experiments from life sciences articles. project will focus set common laboratory...