A5026182443- Retinal Development and Disorders
- Cellular transport and secretion
- Neurobiology and Insect Physiology Research
- Scientific Computing and Data Management
- Parkinson's Disease Mechanisms and Treatments
- Research Data Management Practices
- scientometrics and bibliometrics research
- Academic Writing and Publishing
- Wikis in Education and Collaboration
- Meta-analysis and systematic reviews
- Expert finding and Q&A systems
- Semantic Web and Ontologies
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Freie Universität Berlin
2018-2021
Reproducible research and open science practices have the potential to accelerate scientific progress by allowing others reuse outputs, promoting rigorous that is more likely yield trustworthy results. However, these are uncommon in many fields, so there a clear need for training helps encourages researchers integrate reproducible into their daily work. Here, we outline eleven strategies making norm at institutions. The strategies, which emerged from virtual brainstorming event organized...
Rab GTPases are molecular switches that regulate membrane trafficking in all cells. Neurons have particular demands on and express numerous of unknown function. Here, we report the generation characterization molecularly defined null mutants for 26 rab genes Drosophila . In flies, expressed nervous system where at least half exhibit particularly high levels compared to other tissues. Surprisingly, loss any these 13 system-enriched Rabs yielded viable fertile flies without obvious...
Many-author non-empirical papers include “how to” articles, recommendations or consensus statements, roadmaps for future research, catalogs of ideas, calls to action. These benefit the research community and broader academic ecosystem by addressing unmet needs introducing new perspectives approaches. Large, diverse authorship teams that examine an issue from many different can create valuable resources individual co-authors could not develop independently, in smaller groups. Realizing...
Many-author non-empirical papers include recommendations or consensus statements, catalogs of ideas, roadmaps for future research, calls to action, “how to” articles. These have great potential change the conversation address unmet needs within research communities. Large, diverse authorship teams can create valuable resources that no individual co-author could independently. Achieving these goals, however, requires a very different approach than researchers typically use prepare with fewer...
Across disciplines, researchers increasingly recognize that open science and reproducible research practices may accelerate scientific progress by allowing others to reuse outputs promoting rigorous is more likely yield trustworthy results. While initiatives, training programs, funder policies encourage adopt practices, these are uncommon in many fields. Researchers need integrate into their daily work. We organized a virtual brainstorming event, collaboration with the German Reproducibility...
Abstract Inherited mutations in the LRRK2 protein are commonest known cause of Parkinson’s, but molecular link from increased kinase activity to pathological neurodegeneration remains be determined. In vitro (biochemical and cell culture) assays led hypothesis that several Rab GTPases might substrates. Here we show Rab10 potently modifies - G2019S mediated electrophysiological responses an vivo screen, which each was overexpressed Drosophila dopaminergic neurons. We therefore tested effect...
Summary Rab GTPases are molecular switches that regulate membrane trafficking in all cells. Neurons have particular demands on and express numerous of unknown function. Here we report the generation characterization molecularly defined null mutants for 26 rab genes Drosophila . In addition, created a transgenic fly collection acute, synchronous release system RUSH Rabs. flies, expressed nervous where at least half exhibit particularly high levels compared to other tissues. Surprisingly, loss...
The scholarly publishing system is adapting to many changes including open access and data mandates, new technologies, artificial intelligence. Members of the research communities are working establish a more equitable, fair, rigorous that serves researchers’ evolving needs. Early career researchers (ECRs) drivers change, publishers may wonder why how they should involve ECRs in shaping future publishing. We held virtual unconference explore this issue with who were improve Some participants...