A5031123265- Wnt/β-catenin signaling in development and cancer
- Axon Guidance and Neuronal Signaling
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Bat Biology and Ecology Studies
- Cellular transport and secretion
- Alzheimer's disease research and treatments
- Phytoestrogen effects and research
- Morphological variations and asymmetry
- Caveolin-1 and cellular processes
- Amphibian and Reptile Biology
- Muscle Physiology and Disorders
- Pluripotent Stem Cells Research
- Cellular Mechanics and Interactions
- Cancer-related gene regulation
Masaryk University
2024
Universidade Federal do Rio de Janeiro
2016-2022
The deregulation of the Wnt/β-catenin signaling pathway is a central event in colorectal cancer progression, thus promising target for drug development. Many natural compounds, such as flavonoids, have been described inhibitors and consequently modulate important biological processes like inflammation, redox balance, promotion progress, well cell death. In this context, we identified chalcone lonchocarpin isolated from Lonchocarpus sericeus inhibitor, both vitro vivo. Lonchocarpin impairs...
The Wnt/β-catenin signaling pathway dictates cell proliferation and differentiation during embryonic development tissue homeostasis. Its deregulation is associated with many pathological conditions, including neurodegenerative disease, frequently downregulated. lack of efficient treatment for these diseases, Alzheimer's disease (AD), makes Wnt an attractive target therapies. Interestingly, novel activating compounds are less described than inhibitors, turning the quest positive modulators...
Xenopus laevis, the African clawed frog, is a versatile vertebrate model organism in various biological disciplines, prominently developmental biology to study body plan reorganization during metamorphosis. However, notable gap exists availability of comprehensive datasets encompassing Xenopus' late stages.
Wnt/β-catenin has been described as crucial for dorsal-ventral and antero-posterior patterning, playing multiple roles at different stages of development. Cholesterol-rich membrane microdomains (CRMMs), cholesterol- sphingolipid-enriched domains the plasma membrane, are known platforms signaling pathways. Although we have demonstrated importance CRMMs head development, how they participate in prechordal plate formation embryo axis patterning remains an open question. Moreover, participation...
Actomyosin contractility represents an ancient feature of eukaryotic cells participating in many developmental and homeostasis events, including tissue morphogenesis, muscle contraction cell migration, with dysregulation implicated various pathological conditions, such as cancer. At the molecular level, actomyosin comprises actin bundles myosin motor proteins that are sensitive to posttranslational modifications like phosphorylation. While components well understood, coordination by...