A5085571373- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Mosquito-borne diseases and control
- Parkinson's Disease Mechanisms and Treatments
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Virology and Viral Diseases
- Prion Diseases and Protein Misfolding
- Adenosine and Purinergic Signaling
- Regulation of Appetite and Obesity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Tryptophan and brain disorders
- Endodontics and Root Canal Treatments
- Intensive Care Unit Cognitive Disorders
- Gut microbiota and health
- Neonatal and fetal brain pathology
- Chemokine receptors and signaling
- Neurological disorders and treatments
- Breast Implant and Reconstruction
- Neurological diseases and metabolism
- Primate Behavior and Ecology
- Dietary Effects on Health
- Birth, Development, and Health
Universidade Federal do Rio de Janeiro
2016-2025
BGI Group (China)
2022
Cairo University
2022
Kathmandu University
2022
University of Khartoum
2022
University of Pretoria
2022
University of Jendouba
2022
Children Cancer Hospital
2022
UNESCO
2022
Universidade Federal de Santa Catarina
2006-2021
Abstract Alzheimer's disease ( AD ) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in patients. Here, we show that intracerebroventricular infusion ‐associated Aβ oligomers (AβOs) mice triggered glucose intolerance, a phenomenon further verified two transgenic mouse models . Systemically injected AβOs failed to induce suggesting target brain regions involved control. Accordingly, affected hypothalamic neurons culture,...
Abstract Neurological complications affecting the central nervous system have been reported in adult patients infected by Zika virus (ZIKV) but underlying mechanisms remain unknown. Here, we report that ZIKV replicates human and mouse brain tissue, targeting mature neurons. preferentially targets memory-related regions, inhibits hippocampal long-term potentiation induces memory impairment mice. TNF-α upregulation, microgliosis upregulation of complement proteins, C1q C3, are induced...
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood. Evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein or fragments released from cells during infection, reaching different tissues, including the CNS, irrespective of presence viral RNA. Here, we demonstrate brain infusion mice has a late impact on cognitive function,...
Increased brain deposition of amyloid β protein (Aβ) and cognitive deficits are classical signals Alzheimer's disease (AD) that have been highly associated with inflammatory alterations. The present work was designed to determine the correlation between tumor necrosis factor-α (TNF-α)-related signaling pathways inducible nitric oxide synthase (iNOS) expression in a mouse model AD, by means both vivo vitro approaches. intracerebroventricular injection Aβ 1–40 mice resulted marked learning...
Brain accumulation of soluble amyloid-β oligomers (AβOs) has been implicated in synapse failure and cognitive impairment Alzheimer's disease (AD). However, whether how different sizes induce dysfunction is a matter controversy. Here, we report that low-molecular-weight (LMW) high-molecular-weight (HMW) Aβ differentially impact synapses memory. A single intracerebroventricular injection LMW AβOs (10 pmol) induced rapid persistent mice. On the other hand, memory deficit by HMW was found to be...
alpha-Humulene and trans-caryophyllene are plant sesquiterpenes with pronounced anti-inflammatory properties. Here, we evaluated the effects of these compounds in an experimental model airways allergic inflammation.Female BALB/c mice, sensitized to challenged ovalbumin received daily alpha-humulene or (50 mg.kg(-1), orally) (1 mg.mL(-1), by aerosol) as either a preventive (for 22 days) therapeutic (from 18th 22nd day) treatment. Dexamethasone budesonide was used positive control drug....
Infection by Zika virus triggers epileptic seizures in newborn mice and leads to viral persistence the brain behavioral deficits adulthood.
Zika virus (ZIKV) has been associated to central nervous system (CNS) harm, and was detected in the brain cerebrospinal fluids of microcephaly meningoencephalitis cases. However, mechanism by which reaches CNS is unclear. Here, we addressed effects ZIKV replication human microvascular endothelial cells (HBMECs), as an vitro model blood barrier (BBB), evaluated extravasation BBB integrity a vivo mouse experimental model. HBMECs were productively infected African Brazilian strains (ZIKVMR766...
Obesity has been associated with cognitive decline, atrophy of brain regions related to learning and memory, higher risk developing dementia. However, the molecular mechanisms underlying these neurological alterations are still largely unknown. Here, we investigate effects palmitate, a saturated fatty acid present at high amounts in fat-rich diets, brain. Palmitate is increased cerebrospinal fluid (CSF) overweight obese patients amnestic mild impairment. In mice, intracerebroventricular...
Although produced by several types of tumours, the role serotonin on cancer biology is yet to be understood.The effects (5-HT) human breast cells proliferation, signalling pathways and metabolic profile were evaluated cytometry, western blotting, qPCR, enzymology confocal microscopy.Our results revealed that incubation MCF-7 with 10 µM 5-HT increased cell growth rate 28%, an effect was prevented 5-HTR2A/C antagonist, ketanserin. Conversely, increasing concentrations promoted glucose...
Abstract It is well known the potential of severe acute respiratory coronavirus type 2 (SARS-CoV-2) infection to induce post-acute sequelae, a condition called Long COVID. This syndrome includes several symptoms, but central nervous system (CNS) main one neurocognitive dysfunction. Recently it has been demonstrated relevance plasma levels neurofilament light chain (pNfL), as biomarker early involvement CNS in COVID-19. The aim this study was investigate relationship between pNfL patients...
Cognitive deficits and psychiatric disorders are significant sequelae of traumatic brain injury (TBI). Animal models have been widely employed in TBI research, but few studies addressed the effects experimental different severities on emotional cognitive parameters. In this study, mice were subjected to weight-drop induce mild, intermediate, or severe TBI. After neurological assessment, recovered for 10 days, then a battery behavioral tests, which included open-field, elevated plus-maze,...
The accumulation of amyloid-beta (Aβ) peptides in the brain human and rodents has been associated with activation glial cells, neuroinflammatory oxidative responses, cognitive deficits. These changes leave glutamate transporters more vulnerable may result reduction their functions, resulting excitotoxic damage. Herein, we evaluated effects atorvastatin, a HMG-CoA reductase inhibitor, molecular behavioral alterations induced by single intracerebroventricular injection aggregated Aβ(1-40) (400...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss and cognitive impairments. The presence of extracellular senile plaques (mainly composed amyloid-β (Aβ) peptide) an important molecular hallmark in AD neuronal damage has been attributed, at least part, to Aβ-mediated toxicity. Although the mechanisms involved pathogenesis are not yet completely understood, several lines evidence indicate that oxidative stress cholesterol dyshomeostasis play crucial roles...
alpha- and beta-amyrin are pentacyclic triterpenes found in plants known to exhibit pronounced anti-inflammatory effects. Here, we evaluated the effects of a 1:1 mixture (alpha,beta-amyrin) on an experimental model colitis mice.Colitis was induced Swiss male mice by trinitrobenzene sulphonic acid (TNBS) followed up 72 h; animals were treated systemically with alpha,beta-amyrin, dexamethasone or vehicle. Macro- microscopic damage, myeloperoxidase activity cytokine levels assessed colons....
RoundUp® (RUp) is a comercial formulation containing glyphosate (N-(phosphono-methyl) glycine), and the world’s leading wide-spectrum herbicide used in agriculture. Supporters of broad use glyphosate-based herbicides (GBH) claim they are innocuous to humans, since active compound acts on inhibition enzymes which absent human cells. However, neurotoxic effects GBH have already been shown many animal models. Further, these formulations were disrupt microbiome different species. Here, we...
Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective viral replication resulting in activation pattern recognition receptors (PRRs) and neuroinflammation. Considering microglia dysfunction, which is regulated by whole array purinergic receptors, may be central event neuropathology, we investigated...