A5007004833- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Thyroid Disorders and Treatments
- Treatment of Major Depression
- Nuclear Receptors and Signaling
- Receptor Mechanisms and Signaling
- Epilepsy research and treatment
- Biochemical effects in animals
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Prion Diseases and Protein Misfolding
- Trace Elements in Health
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
Universidade Federal de Santa Catarina
2016-2025
University of Florence
2024
Polydoro Ernani de São Thiago University Hospital
2020-2023
Universidade Federal de Mato Grosso
2015
Universidad Autónoma de Madrid
2014
Universidade Federal do Rio Grande do Sul
1991-2002
Institute of Endocrinology
1976
In the present study, we investigated whether mild-intensity physical exercise represents a successful strategy to enhance spatial learning and memory hippocampal plasticity in aging rats, as previously described for long-term exposure running wheel or treadmill exercise. Aging Wistar rats were submitted short bouts (4-6 min) of during five consecutive weeks. This program increased muscle oxygen consumption by soleus heart reversed age-related impairments evaluated water maze step-down...
Previous studies demonstrate that glyphosate exposure is associated with oxidative damage and neurotoxicity. Therefore, the mechanism of glyphosate-induced neurotoxic effects needs to be determined. The aim this study was investigate whether Roundup(®) (a glyphosate-based herbicide) leads neurotoxicity in hippocampus immature rats following acute (30min) chronic (pregnancy lactation) pesticide exposure. Maternal undertaken by treating dams orally 1% (0.38% glyphosate) during pregnancy...
Mitochondrial perturbation and oxidative stress are key factors in neuronal vulnerability several neurodegenerative diseases or during brain ischemia. Here we have investigated the protective mechanism of action guanosine, guanine nucleoside, a human neuroblastoma cell line, SH-SY5Y, subjected to mitochondrial stress. Blockade complexes I V with rotenone plus oligomycin (Rot/oligo) caused significant decrease viability an increase ROS production. Guanosine that effect guanosine incubated...
The accumulation of amyloid-beta (Aβ) peptides in the brain human and rodents has been associated with activation glial cells, neuroinflammatory oxidative responses, cognitive deficits. These changes leave glutamate transporters more vulnerable may result reduction their functions, resulting excitotoxic damage. Herein, we evaluated effects atorvastatin, a HMG-CoA reductase inhibitor, molecular behavioral alterations induced by single intracerebroventricular injection aggregated Aβ(1-40) (400...
Guanosine (GUO) is an endogenous modulator of glutamatergic excitotoxicity and has been shown to promote neuroprotection in vivo vitro models neurotoxicity. This study was designed understand the neuroprotective mechanism GUO against oxidative damage promoted by oxygen/glucose deprivation reoxygenation (OGD). (100 μM) reduced reactive oxygen species production prevented mitochondrial membrane depolarization induced OGD. also exhibited anti-inflammatory actions as inhibition nuclear factor...
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phenolic compound present in several plants with claimed beneficial effects prevention and treatment of disorders linked to oxidative stress inflammation. In this study, we aimed verify the possible antidepressant-like effect acute oral administration ferulic forced swimming test (FST) tail suspension (TST) mice. Additionally, mechanisms involved action association antidepressants fluoxetine, paroxetine, sertraline TST were investigated....
Abstract Thyroid hormone (T 3 ) regulates the growth and differentiation of rat cerebellar astrocytes. Previously, we have demonstrated that these effects are due, at least in part, to increased expression extracellular matrix molecules factors, such as fibroblast factor‐2. T also modulates neuronal development an astrocyte‐mediated manner. In mammalian central nervous system, excitatory neurotransmission is mediated mainly by glutamate. However, excessive stimulation glutamate receptors can...
Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity millimolar concentrations of hippocampal slices involves apoptotic features glutamate‐induced release. Guanosine, an endogenous guanine nucleoside, prevents excitotoxicty its ability to modulate transport. In this study, we evaluated the neuroprotective effect guanosine against toxicity mechanism such effect. found (100 μM) was 1 mM...
Ferulic acid (FA, 4-hydroxy-3-methoxycinnamic acid) is a phytochemical compound naturally present in several plants and foods that approved as an antioxidant additive food preservative. It exerts beneficial action chronic mild stress-induced depressive-like behavior produces acute antidepressant-like effect the tail suspension test (TST) through activation of serotonergic system. This study was aimed at investigating possible involvement signaling pathways oral administration FA, TST mice....
Familial hypercholesterolemia is caused by inherited genetic abnormalities that directly or indirectly affect the function of low-density lipoprotein (LDL) receptor. This condition characterized defective catabolism LDL which results in increased plasma cholesterol concentrations and premature coronary artery disease. Nevertheless, there increasing preclinical clinical evidence indicating familial subjects show a particularly high incidence mild cognitive impairment. Moreover, receptor...
Quinolinic acid (QA) is an endogenous and potent neurotoxin associated with the neurotoxicity of various common diseases. The uptake neurotransmitters into synaptic vesicles important event involved in storage release by vesicles. influence QA on glutamate, GABA glycine rat brain was investigated. (0.3-10 mM) significantly inhibited (>50%) glutamate vesicles, whereas at concentrations up to 10 mM had no significant effect or uptake. Such results indicate that able selectively inhibit...