A5091902011- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- Cholinesterase and Neurodegenerative Diseases
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Nanoparticle-Based Drug Delivery
- Estrogen and related hormone effects
- Biotin and Related Studies
- Agricultural and Food Sciences
- Endoplasmic Reticulum Stress and Disease
- Tryptophan and brain disorders
- Calcium signaling and nucleotide metabolism
- Antioxidant Activity and Oxidative Stress
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Lysosomal Storage Disorders Research
- Histone Deacetylase Inhibitors Research
- Regulation of Appetite and Obesity
- Ovarian function and disorders
Fundação Oswaldo Cruz
2018-2025
Universidade Federal do Rio de Janeiro
2013-2018
Universidade Federal do Rio Grande do Sul
2005-2013
Universidade Federal de Ciências da Saúde de Porto Alegre
2005-2013
Instituto de Saúde
2012
Abstract Alzheimer's disease ( AD ) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in patients. Here, we show that intracerebroventricular infusion ‐associated Aβ oligomers (AβOs) mice triggered glucose intolerance, a phenomenon further verified two transgenic mouse models . Systemically injected AβOs failed to induce suggesting target brain regions involved control. Accordingly, affected hypothalamic neurons culture,...
Several studies have reported that orally ingested trans-resveratrol is extensively metabolized in the enterocyte before it enters blood and target organs. Additionally, photosensitive, easily oxidized presents unfavorable pharmacokinetics. Therefore, of great interest to stabilize order preserve its biological activities improve bioavailability brain. Here, was loaded into lipid-core nanocapsules analyzed for particle size, polydispersity zeta potential. The nanocapsule distribution brain...
Berberine is an alkaloid derived from herb the Berberis sp. and has long-term use in Oriental medicine. Studies along years have demonstrated its beneficial effect various neurodegenerative neuropsychiatric disorders. The subject of this study was to evaluate whether berberine protects against delayed neuronal cell death organotypic hippocampal culture (OHC) exposed oxygen glucose deprivation (OGD) signaling mechanism related effect. Hippocampal slices were obtained 6 8-days-old male Wistar...
The development of novel therapeutic strategies to treat gliomas remains critical as a result the poor prognoses, inef-. ficient therapies and recurrence associated with these tumors. In this context, biodegradable nanoparticles are emerging efficient drug delivery systems for treatment difficult-to-treat diseases such brain current study, we evaluated antiglioma effect trans-resveratrol-loaded lipid-core nanocapsules (RSV-LNC) based on in vitro (C6 glioma cell line) vivo (brain-implanted C6...
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by accumulation of extracellular deposits amyloid‐β (Aβ) peptide in brain regions that are important for memory and cognition. The buildup Aβ aggregates the AD followed formation intracellular neurofibrillary tangles activation neuroinflammatory reactions. present study investigated whether melatonin possesses neuroprotective effect against Aβ‐induced toxicity. For this purpose, organotypic hippocampal...
Abstract: Neuroinflammation, characterized by the accumulation of activated microglia and reactive astrocytes, is believed to modulate development and/or progression Alzheimer's disease (AD). Epidemiological studies suggesting that nonsteroidal anti-inflammatory drugs decrease risk developing AD have encouraged further elucidating role inflammation in AD. Nanoparticles become an important focus neurotherapeutic research because they are especially effective form drug delivery. Here, we...
Abstract: Glioblastoma (GBM) stands as the most aggressive and lethal among main types of primary brain tumors. It exhibits malignant growth, infiltrating tissue, displaying resistance toward treatment. GBM is a complex disease characterized by high degrees heterogeneity. During tumour microglia astrocytes, other cells, infiltrate microenvironment contribute extensively to gliomagenesis. Tumour-associated macrophages (TAMs), either peripheral origin or representing brain-intrinsic microglia,...
Resveratrol, a natural polyphenolic compound, has attracted considerable interest for its anti-inflammatory and neuroprotective properties. However, the biological effects of resveratrol appear strongly limited because it is photosensitive, easily oxidized, unfavorable pharmacokinetics. The present study aimed to elucidate effect on Abeta-triggered neuroinflammation by comparing free (RSV) treatment with those resveratrol-loaded lipid-core nanocapsules (RSV-LNC). Organotypic hippocampal...
The effect of Aβ25-35 peptide, in its fibrillar and non-fibrillar forms, on ganglioside expression organotypic hippocampal slice cultures was investigated. Gangliosides were endogenously labeled with D-[1-C(14)] galactose results showed that affected expression, depending the peptide aggregation state, is, caused an increase GM3 labeling a reduction GD1b labeling, whereas form able to enhance GM1 expression. Interestingly, exhibited neuroprotective this model, since pre-treatment slices 10...
Abstract: Despite recent advances in radiotherapy, chemotherapy, and surgical techniques, glioblastoma multiforme (GBM) prognosis remains dismal. There is an urgent need for new therapeutic strategies. Nanoparticles of biodegradable polymers anticancer drug delivery have attracted intense interest years because they can provide sustained, controlled, targeted delivery. Here, we investigate the mechanisms involved antiproliferative effect indomethacin-loaded lipid-core nanocapsules...
Alzheimer's disease (AD) is characterized by memory decline and mood alterations. A growing body of evidence implicates stress other social determinants health as potential contributors to the progressive cerebral alterations that culminate in AD. In current study, we investigated impact neonatal maternal separation (MS) on susceptibility male female mice AD-associated impairments depressive-like behavior adulthood, brain levels pro-inflammatory cytokines neurotransmitters. Male Swiss were...