A5089211751- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Insect and Pesticide Research
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Pesticide Residue Analysis and Safety
- Pesticide Exposure and Toxicity
- Seaweed-derived Bioactive Compounds
- Phytochemistry Medicinal Plant Applications
- Multicomponent Synthesis of Heterocycles
- Healthcare and Venom Research
- Pharmacological Effects and Toxicity Studies
- Metal complexes synthesis and properties
- Phytochemical compounds biological activities
- Click Chemistry and Applications
- Microwave-Assisted Synthesis and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Fluorine in Organic Chemistry
- Pesticide and Herbicide Environmental Studies
- Metabolomics and Mass Spectrometry Studies
- Crystallography and molecular interactions
Universidade de Caxias do Sul
2016-2025
Universidade Federal da Grande Dourados
2014-2023
Biotechnology Institute
2016-2023
Universidade Federal de Mato Grosso do Sul
2023
Universidade Nove de Julho
2023
University of Delhi
2023
Zhejiang University
2023
Zhengzhou University
2023
Natura (Brazil)
2015-2022
Instituto de Biotecnología de León
2015-2018
Propolis has been used worldwide for years in folk medicine and currently marketed by the pharmaceutical industry. In Brazil, propolis was classified into 13 groups based on their organoleptics physicochemical characteristics. The 13th type named red an important source of investigation since late 90s. Their property comes from countless compounds, including terpenes, pterocarpans, prenylated benzophenones especially flavonoids. This last compound class indicated as responsible its potent...
Natural products continue to be an invaluable resource of anticancer drug discovery in recent years. Propolis is known for its biological activities such as antimicrobial and antitumor effects. This study assessed the effects Brazilian red propolis (BRP) on apoptosis migration potential human bladder cancer cells. The effect BRP ethanolic extract (25, 50, 100 μg/mL) 5637 cells was determined by MTT, LIVE/DEAD, (scratch assay) assays. Apoptosis induction investigated through flow cytometry...
Most studies of Brazilian red propolis have explored the composition and biological properties its ethanolic extracts. In this work, we chemically extracted characterized essential oil (EOP) assessed adjuvant, antiparasitic cytotoxic activities. The chemical EOP was analyzed using gas chromatography with mass spectrometry (GC-MS). tested for in vitro activity against Trichomonas vaginalis (ATCC 30236 isolate); trophozoites were treated different concentrations (ranging from 25 to 500 μg/mL)...
Since early times, propolis has been used in folk medicine. The red propolis, collected the northeast region of Brazil highlighted due to its popular use as an antimicrobial, with anti-inflammatory and healing properties, which are associated chemical composition. Here, we combine a bacterial membrane treat wounds diabetic mice. This work aims evaluate biocurative from cellulose mice wound model. Biocuratives different extracts were produced. qualification quantification presence compounds...
Smoking crack cocaine involves the inhalation of and its pyrolysis product, anhydroecgonine methyl ester (AEME). Although there is evidence that neurotoxic, neurotoxicity AEME has never been evaluated. seems to have cholinergic agonist properties in cardiovascular system; however, are no reports on effects central nervous system. The aim this study was investigate possible rat primary hippocampal cell cultures were exposed different concentrations AEME, cocaine, a cocaine–AEME combination....
Several volatile natural compounds produced by plant secondary metabolism have been proven to present antimicrobial action, enabling their use in phytopathogen control. They also low environmental impact when compared conventional pesticides. Essential oils contain these and can be found several species, such as Lippia alba (Mill.) N.E. Brown (Verbenaceae). of four chemotypes L. alba, characterized major compounds, namely camphor, citral, linalool camphor/1,8-cineole, were tested against the...
Trichomoniasis is a parasitic infection caused by Trichomonas vaginalis and it considered to be the most common non-viral sexually transmitted in world. Since 1960s, nitroimidazoles such as metronidazole are drugs of choice for treatment trichomoniasis, but many adverse effects allergic reactions may result from their use. Reports metronidazole-resistant infections also highlight importance search new anti-T. agents. Considering this, herein we report evaluation 21 synthetic monocarbonyl...
Natural products are among one of the most promising fields in finding new molecular targets cancer therapy. Laryngeal carcinoma is common cancers affecting head and neck regions, associated with high morbidity rate if left untreated. The aim this study was to examine antiproliferative effect Araucaria angustifolia on laryngeal HEp-2 cells. results showed that A. extract (AAE) induced a significant cytotoxicity cells compared non-tumor human epithelial (HEK-293) cells, indicating selective...
Context: Peripheral axon injury and degeneration are often mediated by oxidative stress inflammation. The hydroalcoholic extract of the red propolis (HERP) has attracted great attention because its antioxidant anti-inflammatory activities.Objective: objective this work is to study effect HERP on nerve repair functional recovery after sciatic (SNI) in rats.Materials methods: chemical markers were identified using high-resolution mass spectroscopy. After axonotmesis nerve, ibuprofen (IBP)...
The microdiscectomy used for the treatment of intervertebral disc disorders leaves an open incision in annulus fibrosus that must be sealed to avoid re-herniation and other subsequent degenerations. In this study, we developed injectable situ polymerizable polyurethane adhesive as a long-term post-surgical repair strategy. It was investigated chemical structure urethane-based its physico-chemical, viscoelastic, kinetic, vitro cytotoxic properties. formulated from polycarbonate diol with...
Red propolis is a natural resin mixture produced by honeybees and presents source of active compounds with variety biological activities. In this study, we describe the chemical characterization potential antitumor activity total extract Brazilian red its fractions. Fractions were obtained through column chromatography revealing 14 different in all samples, which determined distinguished other isobar molecules fragmentation pathways ESI-MS/MS positive mode. Some as cis-asarone or...