A5087750570- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- Nanoplatforms for cancer theranostics
- Antibiotics Pharmacokinetics and Efficacy
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Porphyrin and Phthalocyanine Chemistry
- ZnO doping and properties
- Pharmaceutical studies and practices
- Diabetes Treatment and Management
- Gastroesophageal reflux and treatments
- Antibiotic Use and Resistance
- Advanced Photocatalysis Techniques
- HIV-related health complications and treatments
- Drug-Induced Hepatotoxicity and Protection
- Pregnancy and Medication Impact
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Bariatric Surgery and Outcomes
- Oral and gingival health research
- Biological Stains and Phytochemicals
- Advancements in Transdermal Drug Delivery
- Cancer Treatment and Pharmacology
Unidade Hospitalar de Bragança
2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Bristol-Myers Squibb (United Kingdom)
2025
University of Liverpool
2020-2024
Pfizer (United Kingdom)
2024
Universidade Estadual de Maringá
2014-2020
Long-acting cabotegravir and rilpivirine have been approved to manage HIV in adults, but data regarding safe use pregnancy are limited. Physiologically-based pharmacokinetic (PBPK) modelling was used simulate the dosing regimens explore if C
Upadacitinib, classified as a highly soluble drug, is commercially marketed RINVOQ®, modified-release formulation incorporating hydroxypropyl methylcellulose matrix system to target extended release throughout the gastrointestinal (GI) tract. Our study aimed explore how drug will occur GI tract using plethora of in vitro and silico tools. We built Physiologically-Based Pharmacokinetic (PBPK) model GastroPlus™ predict systemic concentrations when administered dissolution profiles input drive...
Ritonavir-boosted atazanavir (ATV/r) and rifampicin are mainstays of second-line antiretroviral multiple anti-TB regimens, respectively. Rifampicin induces CYP3A4, a major enzyme involved in metabolism, causing drug-drug interaction (DDI) which might be exaggerated pregnancy. Having demonstrated that increasing the dose ATV/r from once daily (OD) to twice (BD) non-pregnant adults can safely overcome this DDI, we developed pregnancy physiologically based pharmacokinetic (PBPK) model explore...
Brucellosis is a disease caused by an intracellular Gram-negative coccobacillus, which presents nonspecific symptoms and difficult to diagnose. There are several species of the genus Brucella currently known involved in its pathogenesis. In Portugal, Bragança district, melitensis stands out as infection agent. Since 1990s, diagnostic tests associated with brucellosis have become more regularly part clinical laboratory practice. recent years, new cases been identified humans within Local...
Abstract Aim To characterize the impact of obesity and Roux-en-Y gastric bypass (RYGB) on systemic exposure to amoxicillin using population modeling approach. We also performed simulations provide insights into optimising dosing against infectious bacteria in respiratory tract. Methods Non-obese, obese, post-RYGB patients, aged between 24 50 years, from two clinical studies, were evaluated. Sex, age, body size descriptors, history bariatric surgery renal function assessed as potential...
Bladder cancer is the second type of malignant carcinoma urinary tract. The treatment time-consuming and requires maintenance doses drug for long period time with important side effects. Curcumin has shown evident clinical advances in cancer. technology microencapsulation use mucoadhesive materials can contribute to modify delivery improve bioavailability curcumin.The aim this study was design characterize microparticles containing curcumin using multivariate analysis spray-drying...
Aims To compare the pharmacokinetics of amoxicillin (AMX) in obese and nonobese subjects, given as single dose 875‐mg tablets. Methods A prospective, single‐centre, open‐label, clinical study was carried out involving 10 20 subjects a an AMX tablet. Serial blood samples were collected between 0 8 hours after administration plasma levels quantified by liquid chromatography–tandem mass spectrometry. The pharmacokinetic parameters (PK) calculated noncompartmental analysis means 2 groups...
The aim of this study was to simulate the drug–drug interaction (DDI) between ritonavir-boosted atazanavir (ATV/r) and rifampicin (RIF) using physiologically based pharmacokinetic (PBPK) modelling, predict suitable dose adjustments for ATV/r treatment people living with HIV (PLWH) co-infected tuberculosis. A whole-body DDI PBPK model designed Simbiology 9.6.0 (MATLAB R2019a) verified against reported clinical data all drugs administered alone concomitantly. contained induction mechanisms RIF...
Background: Breast cancer is the most relevant type of and second cause cancer- related deaths among women in general. Currently, there no effective treatment for breast although advances its initial diagnosis are available. Therefore, value novel anti-tumor therapeutic modalities remains an immediate unmet need clinical practice. Following our previous work regarding properties Pluronics with different photosensitizers (PS) photodynamic therapy (PDT), this study we aimed to evaluate...
Abstract Background Critical drug-drug interactions (DDI) and hepatotoxicity complicate concurrent use of rifampicin protease inhibitors. We investigated whether dose escalation atazanavir/ritonavir could safely overcome the DDI with rifampicin. Methods DERIVE (NCT04121195, EDCTP) was a dose-escalation trial in people human immunodeficiency virus (HIV) on atazanavir/ritonavir-based antiretroviral therapy (ART) Uganda. Four intensive pharmacokinetic (PK) visits were performed: PK1 300/100 mg...
Aims To evaluate the relative bioavailability of oral amoxicillin (AMX) tablets in comparison to AMX suspension Roux‐en‐Y gastric bypass bariatric subjects. Methods A randomized, double‐blind, cross‐over study was performed on and subjects operated at least 3 months previously . Doses 875 mg tablet or 800 were given all subjects, allowing a washout 7 days between periods. Blood samples collected 0, 0.25, 0.5, 1, 1.5, 2, 4, 6 8 hours after drug administration levels quantified by liquid...
The aim of the study was to apply Physiologically-Based Pharmacokinetic (PBPK) modelling predict effect liver disease (LD) on pharmacokinetics (PK) dexamethasone (DEX) in treatment COVID-19. A whole-body PBPK model created simulate 100 adult individuals aged 18-60 years. Physiological changes (e.g., plasma protein concentration, size, CP450 expression, hepatic blood flow) and portal vein shunt were incorporated into LD model. implemented by using Child-Pugh (CP) classification system. DEX...
The potential of a physiologically-based pharmacokinetic (PBPK) model to predict oral amoxicillin bioavailability, by considering the physiological changes after "Roux-en-Y gastric bypass" (RYGB) surgery in bariatric patients, was evaluated. A middle-out approach for parameter estimations undertaken using vitro, situ, and vivo data. observed versus predicted plasma concentrations sensitivity simulated parameters AUC0-inf Cmax (AMX) were used confirm reliability estimation. considers that...
Patients undergoing Roux-en-Y gastric bariatric (RYGB) surgery present a reduced absorption site, and special attention should therefore be taken when prescribing oral-dosage forms. This study was carried out to investigate the extent which non-bariatric clinicians are aware of this issue medicines for population, what type information is available aid them in their decision-making.Two questionnaires were created, one another patients who had undergone RYGB surgery, gather about prescription...