A5080242303- Cervical Cancer and HPV Research
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- HIV/AIDS oral health manifestations
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Essential Oils and Antimicrobial Activity
- Porphyrin and Phthalocyanine Chemistry
- COVID-19 Impact on Reproduction
- Neurological Disease Mechanisms and Treatments
- Natural Compound Pharmacology Studies
- Genital Health and Disease
- Cancer Mechanisms and Therapy
- Virology and Viral Diseases
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Molecular Biology Techniques and Applications
- Reproductive tract infections research
- Global Cancer Incidence and Screening
- Nanoparticle-Based Drug Delivery
- Gender Politics and Representation
- Bee Products Chemical Analysis
- Flavonoids in Medical Research
Universidade Estadual de Maringá
2018-2025
Background: In the past few years, antiproliferative activities of chrysin (5,7-dihydroxyflavone) have garnered significant attention in anticancer drug discovery due to its promising ability suppress cancer cell proliferation. However, studies on effects cervical are limited and primarily focused HeLa cells. Objective: order better understand therapeutic potential for cancer, we assessed anti-migratory a wide range human-derived lines comprising C33A (human papillomavirus/HPV-negative),...
Background: Breast cancer is the most relevant type of and second cause cancer- related deaths among women in general. Currently, there no effective treatment for breast although advances its initial diagnosis are available. Therefore, value novel anti-tumor therapeutic modalities remains an immediate unmet need clinical practice. Following our previous work regarding properties Pluronics with different photosensitizers (PS) photodynamic therapy (PDT), this study we aimed to evaluate...
Objective: Breast cancer (BC) currently has no effective treatment especially for the highly aggressive and metastatic triple negative breast (TNBC). Here, we investigated antitumoral antimigratory effects of hypericin (HYP) encapsulated on Pluronic F127 (F127/HYP) photodynamic therapy (PDT) against TNBC cell line MDA-MB-231 compared to a nontumorigenic human ductal (MCF-10A). Methods: The phototoxicity/cytotoxicity was assessed by MTT assay, long-term cytotoxicity clonogenic uptake,...
Despite the demonstrated role of human Papillomavirus (HPV) in etiology cervical cancer and strong evidence suggesting importance HPV development oropharyngeal cancer, several aspects interrelationship between infection both body sites remain unknown, specifically female immunodeficiency virus (HIV)-positive (HIV+) patients. We aimed to assess prevalence, distribution, concordance oral HIV+ women matched HIV-negative (HIV-) controls Brazil.Cervical endocervical samples for cytological...
Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to best our knowledge, there are no studies artepillin in cervical cancer.To explore a new therapeutic candidate for cancer, we have evaluated effects on cellular viability comprehensive panel human cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki 16-...
Cervical cancer is a leading cause of death among women. The endocervical adenocarcinoma (ECA) represents an aggressive and metastatic type with no effective treatment options currently available. We evaluated the antitumoral anti-migratory effects hypericin (HYP) encapsulated on Pluronic F127 (F127/HYP) photodynamic therapy (PDT) against human cell line derived from invasive cervical (HeLa) compared to epithelial (HaCaT). phototoxicity cytotoxicity F127/HYP were by following assays:...
Background:: Breast cancer is the most commonly diagnosed among women worldwide with limited treatment options. Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) one of main constituents Brazilian propolis presenting different activities, including antitumoral effects against various types cancer. Objective:: We evaluated potential and mechanisms action artepillin two distinct human breast cell lines, MCF-7 MDA-MB-231, to explore a new therapeutic candidate. Methods:: Cell viability was...
Abstract Background: Despite the demonstrated role of human Papillomavirus (HPV) in etiology cervical cancer and strong evidence suggesting importance HPV development oropharyngeal cancer, several aspects concerning interrelationship between infections both body sites remain unknown, specifically immunodeficiency virus (HIV)-positive (HIV+) female patients. We aimed to assess prevalence, distribution, concordance HIV+ women matched HIV-negative (HIV-) controls Brazil. Material methods:...
Abstract Background: Despite the demonstrated role of human Papillomavirus (HPV) in etiology cervical cancer and strong evidence suggesting importance HPV development oropharyngeal cancer, several aspects interrelationship between infection both body sites remain unknown, specifically female immunodeficiency virus (HIV)-positive (HIV+) patients. We aimed to assess prevalence, distribution, concordance oral HIV+ women matched HIV-negative (HIV-) controls Brazil. Material methods: Cervical...
Abstract Background: Despite the demonstrated role of human Papillomavirus (HPV) in etiology cervical cancer and strong evidence suggesting importance HPV development oropharyngeal cancer, several aspects concerning interrelationship between infection both body sites remain unknown, specifically immunodeficiency virus (HIV)-positive (HIV+) female patients. We aimed to assess prevalence, distribution, concordance oral HIV+ women matched HIV-negative (HIV-) controls Brazil. Material methods:...
Abstract Background: Despite the demonstrated role of human Papillomavirus (HPV) in etiology cervical cancer and strong evidence suggesting importance HPV development oropharyngeal cancer, several aspects interrelationship between infection both body sites remain unknown, specifically female immunodeficiency virus (HIV)-positive (HIV+) patients. We aimed to assess prevalence, distribution, concordance oral HIV+ women matched HIV-negative (HIV-) controls Brazil. Material methods: Cervical...