A5035696835- Cancer, Hypoxia, and Metabolism
- Medical and Biological Ozone Research
- Antifungal resistance and susceptibility
- Bee Products Chemical Analysis
- Metabolism, Diabetes, and Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Flavonoids in Medical Research
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Health, Education, and Aging
- Caveolin-1 and cellular processes
- Asthma and respiratory diseases
- Parasitic Infections and Diagnostics
- Advanced Drug Delivery Systems
- Mosquito-borne diseases and control
- Oral microbiology and periodontitis research
- Skin Protection and Aging
- Ion Transport and Channel Regulation
- Antioxidant Activity and Oxidative Stress
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Phytochemistry Medicinal Plant Applications
- Healthcare during COVID-19 Pandemic
- Health, Nursing, Elderly Care
- Reliability and Agreement in Measurement
Universidade Estadual de Maringá
2013-2025
Centro Universitário Cesumar
2022-2024
University of Illinois Chicago
2015-2017
Illinois College
2015
Recently, the cytotoxic effects of apigenin (4′,5,7‐trihydroxyflavone), particularly its marked inhibition cancer cell viability both in vitro and vivo, have attracted attention anticancer drug discovery field. Despite this, there are few studies cervical cancer, these mostly been conducted using HeLa cells. To evaluate possibility as a new therapeutic candidate for we evaluated comprehensive panel human cancer‐derived lines including (human papillomavirus/HPV 18‐positive), SiHa (HPV...
Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity thus promising for the prevention of UVB-induced photodamage. The aim this study was evaluate protective effect DHCA against apoptosis, matrix metalloproteinase (MMP) expression via mitogen-activated protein kinase (MAPK) signaling pathway on L929...
Aerobic glycolysis is an indispensable component of aggressive cancer cell metabolism. It also distinguishes cells from most healthy types in the body. Particularly for this reason, targeting metabolism to improve treatment outcomes has long been perceived as a potentially valuable strategy. In practice, however, our limited knowledge why and how metabolic reprogramming occurs prevented progress towards therapeutic interventions that exploit peculiarities tumors. We recently described breast...
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated of naringenin ROS production, specifically hypochlorous acid (HOCl), involvement neutrophils. inhibited HOCl through different systems, but this inhibition was more pronounced for quercetin, even...
Vulvovaginal candidiasis (VVC) is among the most prevalent vaginal diseases. Candida albicans still species associated with this pathology, however, prevalence of other species, such as C. glabrata, increasing. The pathogenesis these infections has been intensely studied, nevertheless, no consensus reached on pathogenicity VVC. In addition, inappropriate treatment or presence resistant strains can lead to RVVC (vulvovaginal recurrent). Immunomodulation therapy studies have become...
A acalasia é uma patologia rara, com incidência aproximada de 1 em 100.000, sem distinção entre sexo, porém podemos ressaltar que ela pode ser doença secundaria a chagas. fisiopatologia entendida como plexopatia mioentérica autoimune, por vias anticorpos, relacionado o esfíncter esofágico inferior, e no corpo do esôfago descrita neuropatia generalizada, podendo apresentar sintomas mais comuns disfagia, regurgitação, perda peso outros evoluir até para um deslocamento conteúdo as...
Background: In the past few years, antiproliferative activities of chrysin (5,7-dihydroxyflavone) have garnered significant attention in anticancer drug discovery due to its promising ability suppress cancer cell proliferation. However, studies on effects cervical are limited and primarily focused HeLa cells. Objective: order better understand therapeutic potential for cancer, we assessed anti-migratory a wide range human-derived lines comprising C33A (human papillomavirus/HPV-negative),...
Abstract To avoid aging and ultraviolet mediated skin disease the cell repair machinery must work properly. Neutrophils, also known as polymorphonuclear leukocytes, are first most abundant types which infiltrate sites of irradiation play an important role in restoring microenvironment homeostasis. However, infiltration neutrophils ultraviolet‐B (UV‐B) irradiated might contribute to pathophysiology disease. The leukocytes activation induced by UV‐B exposure may lead prolonged, sustained NADPH...
The aim of this work was to compare, from a parasitological ( Cryptosporidium spp. and Giardia duodenalis), bacteriological (total thermotolerants coliforms) physicochemical perspective, water sources used for drinking irrigation vegetables intended be sold human consumption. From January 2010 May 2011, samples different vegetable producing properties were collected; 100 liters analysis, 200 mL five analysis. Water filtered under vacuum with kit containing cellulose acetate membrane filter,...
Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to best our knowledge, there are no studies artepillin in cervical cancer.To explore a new therapeutic candidate for cancer, we have evaluated effects on cellular viability comprehensive panel human cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki 16-...
Catabolic conditions like acquired immunodeficiency syndrome, cancer, and burn can cause immunosuppression. Amino acids such as alanine glutamine are essential for the activity of immune system. Propolis is immunostimulant waste propolis extraction has been reused with technological therapeutic purposes. Therefore, this study describes association byproduct extract (BPE) pectin to prepare spray-dried microparticles containing dipeptide l-alanyl-l-glutamine stimulant systems neutrophils. The...
Aim: To investigate whether Brazilian green propolis improves the immune response against recurrent form isolate vulvovaginal candidiasis (RVVC) caused by Candida albicans increasing neutrophil oxidative burst. Materials & methods: We evaluated oxidant species production, oxygen consumption, microbicidal activity and myeloperoxidase in neutrophils previously treated with activated different isolates of C. (RVVC), candidiasis, asymptomatic reference strain. Results: Propolis significantly...
O consumo de bebidas energéticas está cada vez mais frequente, sobretudo, dentro das universidades. Embora se tenha efeitos interesse, como manter a disposição e ajudar em períodos prova, existem vários adversos documentados à saúde. Com base nisso, o objetivo deste trabalho é investigar prevalência do entre estudantes medicina uma universidade Maringá-PR fatores relacionados, hábitos vida, características pessoais, conhecimento sobre as possíveis colaterais. Trata-se um estudo observacional...
A dengue é uma infecção viral transmitida por mosquitos do gênero Aedes, considerada dasmaiores preocupações mundiais de Saúde Pública, apresentando ampla incidência nos paísestropicais e subtropicais. Os agentes etiológicos são Arbovírus pertencentes à família Flaviviridae.Os quatro sorotipos vírus dengue, denominados I, II, III IV pertencem a esta dogênero Flavivírus. principais vetores da Aedes das espécies aegypti ealbopictus. Após picarem indivíduos virêmicos, transferem pela picada, os...
AMP‐activated kinase (AMPK) is a central metabolic regulator activated by deficits in nutrient supply. The role of AMPK cancer has been contentious with both oncogenic and tumor suppressive roles being proposed. Studies our group indicated that breast cancer, activation promotes evolution towards more aggressive phenotypes. These studies, however, were heavily criticized based on the argument metformin, biguanidine drug used to treat diabetes, activates kills cells. Hence, we set up test...
A Covid-19 é uma doença infectocontagiosa causada pelo coronavírus do tipo SARS-CoV-2, que atingiu estágio de pandemia em 2020, devido à sua alta capacidade transmissibilidade, além poder ser assintomática ou até atingir um quadro insuficiência respiratória, e não contar com tratamento específico. O objetivo da pesquisa estudar as características a prevalência cefaleia por Covid-19, comparando suas características, meio exploratória pacientes pós-Covid-19 (formulários online formulados via...