A5052670259- Phytochemical compounds biological activities
- Phytochemistry Medicinal Plant Applications
- Agricultural and Food Sciences
- Bee Products Chemical Analysis
- Microencapsulation and Drying Processes
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Cholinesterase and Neurodegenerative Diseases
- Research on Leishmaniasis Studies
- Bioactive Natural Diterpenoids Research
- Synthesis and Characterization of Heterocyclic Compounds
- Plant-Microbe Interactions and Immunity
- Plant-derived Lignans Synthesis and Bioactivity
- Proteoglycans and glycosaminoglycans research
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Ethnobotanical and Medicinal Plants Studies
- Advanced Drug Delivery Systems
- Medicinal Plants and Neuroprotection
- Enzyme Production and Characterization
- Phytochemistry and Bioactivity Studies
- Botanical Research and Applications
- Plant-Derived Bioactive Compounds
- Food, Nutrition, and Cultural Practices
- Medical and Biological Ozone Research
Universidade Tecnológica Federal do Paraná
2015-2024
Universidade Estadual de Maringá
2003-2017
Citrus canker is a lot destructive disease of citrus species. The challenge to find new compounds that show strong antibiotic activity, low toxicity plants and the environment. objectives present study are (1) produce, purify evaluate activity secondary metabolites produced by induction P. aeruginosa LV strain in vitro against Xanthomonas citri subsp. (strain 306), (2) potential for semi-purified on foliar application control under greenhouse conditions, (3) identify orange leaf mesophyll...
Porophyllum ruderale (Jacq.) Cass. is a plant native to Brazil and in the northwest region of state Paraná, Brazil, aerial parts P. have been used popularly treatment lesions caused by Leishmania sp.. In this study antileishmanial cytotoxic activities crude extract, fractions, isolated compounds from was evaluated. The dichloromethane extract submitted chromatography yield active against amazonensis. Their structures were established comparison their spectroscopic data with literature...
Arctium lappa L. (Asteraceae) is used in folk medicine around the World, and shows several kinds of biological activity, particularly vitro antitumor activity different cell lines. This study evaluated antiproliferative crude extract, semipurified fractions, isolated compounds from leaves A. lappa, through bioassay-guided testing Caco-2 cells. The extract was obtained with a 50% hydroethanolic then partitioned hexane, ethyl acetate, n-butanol. ethyl-acetate fraction (EAF) showed activity....
Alzheimer's disease (AD) is the most common form of dementia and has no cure. Therapeutic strategies focusing on reduction oxidative stress, modulation amyloid-beta (Aβ) toxicity inhibition tau protein hyperphosphorylation are warranted to avoid development progression AD. The aim this study was screen crude extracts (CEs) ethyl-acetate fractions (EAFs) Guazuma ulmifolia, Limonium brasiliense, Paullinia cupana, Poincianella pluviosa, Stryphnodendron adstringens Trichilia catigua using...
Summary This study aimed to characterize propolis with respect its antioxidant activity and apply it the elaboration of Italian-type salami. A sample was collected subjected chemical physicochemical characterization capacity determined. Four salami formulations were developed: F1 (no antioxidants); F2 (addition 0.01% BHT); F3 propolis) F4 0.05% propolis). The salamis evaluated their properties lipid oxidation. showed a high level waxes low levels phenolic compounds flavonoids, although in...
Herpes simplex virus type 1 (HSV-1) is associated with orofacial infections and transmitted by direct contact infected secretions. Several efforts have been expended in the search for drugs to treatment herpes. Schinus terebinthifolius used several illnesses among them, topical of skin wounds, especially wounds mucous membranes, whether or not.To evaluate cytotoxicity anti-HSV-1 activity crude hydroethanolic extract (CHE) from stem bark S. terebinthifolius, as well its fractions isolated...
The crude acetone extract (CAE) of defatted inflorescences Tagetes patula was partitioned into five semipurified fractions: n-hexane (HF), dichloromethane (DF), ethyl acetate (EAF), n-butanol (BF), and aqueous (AQF). BF fractionated by reversed-phase polyamide column chromatography, obtaining 34 subfractions, which were subjected to HSCCC, where patuletin patulitrin isolated. CAE the fractions BF, EAF, DF, AQF analyzed LC-DAD-MS, determined as major substances in EAF respectively. also HPLC...
Bioguided fractionation of a hydroethanolic extract from the stem bark Croton echioides Baill.led to isolation new indole alkaloid N-trans-feruloyl-3,5-dihydroxyindolin-2-one as stereoisomeric mixture and known alkaloids N-trans-p-coumaroyl-tryptamine, N-trans-pcoumaroyl-5-hydroxytryptamine, N-trans-4-methoxy-cinnamoyl-5-hydroxytryptamine, N-transferuloyl-5-hydroxytryptamine (moschamine), ethyl acetate fraction.The flavonoids 3-o-methyl kaempferol, quercetin, 3,7-di-o-methyl quercetin...
The waste material from the preparation of propolis extracts is a potential natural compound for application in pharmaceutical and medicine nanostructured products. Ascorbic acid an excellent antioxidant important cofactor several physiological biochemical processes.The aim this study was to develop characterize nanoparticles containing L-ascorbic prepared with byproduct.Nanoparticle's physicochemical characteristics (surface morphology, particle size, zeta potential, entrapment efficiency),...
Abstract The search for compounds with anticancer effects is of paramount importance today due to the high incidence disease. Euphorbiaceae family known having therapeutic properties, one its genera being Croton. It has several species, which contain already their biological activities, presenting anti-inflammatory, antimicrobial and properties. Thus, cytotoxicity/antiproliferative activity semi-purified fractions isolated from Croton echioides in liver tumor cells Rattus norvegicus (HTC)...
Catabolic conditions like acquired immunodeficiency syndrome, cancer, and burn can cause immunosuppression. Amino acids such as alanine glutamine are essential for the activity of immune system. Propolis is immunostimulant waste propolis extraction has been reused with technological therapeutic purposes. Therefore, this study describes association byproduct extract (BPE) pectin to prepare spray-dried microparticles containing dipeptide l-alanyl-l-glutamine stimulant systems neutrophils. The...
Nowadays, new leishmanicidal drugs are needed and natural products arise as a promising alternative source. Therefore, bioguided fractionation of hydroethanolic extract from the stem bark Croton echioides Baill. were conducted based on its antileishmanial activity. Two novel neo-clerodane diterpenoids methyl-15,16-epoxy-3,13(16),14-neo-clerodatrien-17,18-dicarboxylate (1) dimethyl-3-oxo-15,16-epoxy-13(16),14-neo-clerodadien-17,18-dicarboxylate (2) isolated, well four known compounds (3-6)...
The β-carboline-1,3,5-triazine hydrochlorides 8-13 were evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). analysed compounds selective to BuChE, with IC50 values the range from 1.0-18.8 µM being obtained. N-{2-[(4,6-dihydrazinyl-1,3,5-triazin-2-yl)amino]ethyl}-1-phenyl-β-carboline-3-carboxamide (12) was most potent compound kinetic studies indicate that it acts as a competitive inhibitor of BuChE. Molecular docking show 12 strongly interacts residues...
From woods of Picrasma crenata , a new stereoisomer dihydronorneoquassin was obtained together with others well knowns dihydronorneoquassin, parain, f -neoquassin, g -neoquassin and quassin. The structures were determined by spectroscopic data chemical evidence.
Croton echioides Baill., Euphorbiaceae, is a small tree found in Bahia, Northeastern Brazil. Its stem bark has been widely sold as an aphrodisiac and tonic, substitute for the roots of Ptychopetalum olacoides Benth. Olacaceae, Amazon Muira Puama or Marapuama, C. characterized "Northeastern Marapuama". This contribution describes morphoanatomical analysis pharmacognostic study this species. The thick cortex with compound starch grains laticifers; sclerenchymatic sheath which consists...
Trichilia catigua is a tree known as "catuaba", widely distributed in Brazil. Studies carried out with T. barks suggest that plant has antidepressant, antidiabetic, antimicrobial, antioxidant, antiviral, and preventive against brain damage. The aim of this work was to isolate characterise compounds from the semipurified fraction barks, conduct microbiological screening bacteria fungi. crude extract (CE) "catuaba" produced by turbo extraction acetone-water, later, partitioned yield...
Abstract Picrasma crenata is a Brazilian tree, which utilized to treat Diabetes mellitus, gastric perturbation, and hypertension. Quassinoids are the main constituents obtained from wood of this plant. The relationship between quassinoids biological effects reveal interest quantifying these in P. wood, as well validation analytical methodologies. This work was designed, therefore, develop an HPLC system separate quassin quantify it extractive solution crenata. parameters method also...