A5020453166- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect Pest Control Strategies
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Traditional and Medicinal Uses of Annonaceae
- Nanoplatforms for cancer theranostics
- Proteins in Food Systems
- Graphene and Nanomaterials Applications
- Aerogels and thermal insulation
- Radiation Therapy and Dosimetry
- Polysaccharides Composition and Applications
- Carbohydrate Chemistry and Synthesis
- Electrospun Nanofibers in Biomedical Applications
- Nanocomposite Films for Food Packaging
- Wound Healing and Treatments
- Bee Products Chemical Analysis
- Mesoporous Materials and Catalysis
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- biodegradable polymer synthesis and properties
- Nanoparticles: synthesis and applications
- Photodynamic Therapy Research Studies
Universidade Estadual de Maringá
2016-2025
Universidade Estadual de Londrina
2021-2023
Cancer is one of the most common diseases nowadays and derives from uncontrollable growth a single cell. Magnetic nanoparticles (NpMag) offer various possibilities for use in biomedical area, including drug delivery mediated by magnetic fields. In current study, we evaluated vitro effects iron-oxide conjugated with antitumor doxorubicin (Dox) on human breast cancer cells. Our results revealed that Dox (NpMag+Dox) induce cellular redox imbalance MCF-7 We also demonstrate functionalized...
Thermosensitive hydrogels based on chitosan/pectin (CS/Pec) and CS/Pec/gold nanoparticles (CS/Pec/AuNPs) were successfully prepared with different AuNP levels. Using a tilting method, gelation temperature was demonstrated to decrease when the amount of AuNPs increased pectin concentrations decreased. The presence in CS/Pec composite evaluated via WAXS UV–vis techniques, while SEM analysis assessed average size pores (350–600 μm). All samples extremely cytocompatible many cell types, such as...
Hydrogels based on alginate and tanfloc (a cationic biopolymer obtained from natural condensed tannins) were successfully prepared. Tanfloc (TN) presents high aqueous solubility at pHs lower than 10; it contains substituted amino sites molar weight of ca. 600,000gmol-1. A factorial design (22) was used to optimize the yield alginate/tanfloc polyelectrolyte complexes (PECs). Dialysis recovered overplus (AG) no complexed with TN. These materials characterized by thermal analyses (TGA/DTG DSC),...
In this study, we show the synthesis of novel hybrid organic-inorganic aerogel materials with one-dimensionally aligned pores and demonstrate their use as sustained prolonged release systems for a hydrophobic drug. The are synthesized by trapping mesoporous silica nanoparticles within hyperbranched polymer network made from poly(vinyl alcohol) (PVA) poly(acrylic acid) (PAA). synthetic method involves dispersing in solution, then freeze-drying finally subjecting resulting to high temperature...
Natural compounds have shown good potential for the discovery of new chemotherapeutics treatment Chagas' disease. Recently, our group reported effective trypanocidal activity (-)-elatol, extracted from red macroalgae Laurencia dendroidea present in Brazilian coast against Trypanosoma cruzi. However, mechanism action this compound has remained unclear. There are only hypotheses concerning its on mitochondrial function. Here, we further investigated mechanisms (-)-elatol trypomastigotes T. For...
Alzheimer's disease (AD) is the most common form of dementia and has no cure. Therapeutic strategies focusing on reduction oxidative stress, modulation amyloid-beta (Aβ) toxicity inhibition tau protein hyperphosphorylation are warranted to avoid development progression AD. The aim this study was screen crude extracts (CEs) ethyl-acetate fractions (EAFs) Guazuma ulmifolia, Limonium brasiliense, Paullinia cupana, Poincianella pluviosa, Stryphnodendron adstringens Trichilia catigua using...
Our group assays natural products that are less toxic and more effective than available nitroheterocycles as promising therapeutic options for patients with Chagas disease. previous study reported the trypanocidal activity of eupomatenoid-5, a neolignan isolated from leaves Piper regnellii var. pallescens, against three main parasitic forms Trypanosoma cruzi. The present further characterizes biochemical morphological alterations induced by this compound to elucidate mechanisms action...
ABSTRACT Despite ongoing efforts, the available treatments for Chagas' disease are still unsatisfactory, especially in chronic phase of disease. Our previous study reported strong trypanocidal activity dibenzylideneacetones A3K2A1 and A3K2A3 against Trypanosoma cruzi (Z. Ud Din, T. P. Fill, F. de Assis, D. Lazarin-Bidóia, V. Kaplum, Garcia, C. Nakamura, K. Oliveira, E. Rodrigues-Filho, Bioorg Med Chem 22:1121–1127, 2014, http://dx.doi.org/10.1016/j.bmc.2013.12.020 ). In present study, we...
Chagas’ disease is an infection that caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because severe side effects and variable efficacy, current treatments for are unsatisfactory, making search new chemotherapeutic agents essential. Previous studies have reported various biological activities naphthoquinones, such as trypanocidal antitumor activity vitamin K3. The combination this with C exerted better against cancer cells than when used alone. These been...
Because of its severe side effects and variable efficacy, the current treatment for Chagas disease is unsatisfactory. Natural compounds are good alternative chemotherapeutic agents this infection. Recently, our group reported antiproliferative activity morphological alterations in epimastigotes intracellular amastigotes Trypanosoma cruzi treated with eupomatenoid-5, a neolignan isolated from leaves Piper regnellii var. pallescens. Here, we demonstrate that eupomatenoid-5 exhibited against...
Leishmania spp. are protozoa responsible for leishmaniasis, a neglected disease that kills up to 50,000 people every year. Current therapies mainly rely on antimonial drugs inadequate because of their poor efficacy and safety increased drug resistance. An urgent need exists find new more affordable drugs. Our previous study demonstrated the antileishmanial activity eupomatenoid-5, neolignan obtained from leaves Piper regnellii var. pallescens . The aim present was clarify mode action...
This work evaluated the in vitro and vivo activity of TDZ 2 on Trypanosoma cruzi amastigotes determined possible mechanism action this compound T. death. inhibited proliferation had low haemolytic potential. It also induced morphological ultrastructural alterations. We observed a reduction cell volume, depolarization mitochondrial membrane, an increase ROS production, lipoperoxidation lipid bodies formation production nitric oxide, decrease reduced thiols levels and, presence autophagic...
Over the past years, natural products have been explored in order to find biological active substances treat various diseases. Regarding their potential action against parasites such as trypanosomatids, specially Trypanosoma cruzi and Leishmania spp., much advance has achieved. Extracts purified molecules of several species from genera Piper, Tanacetum, Porophyllum, Copaifera widely investigated by our research group exhibited interesting antitrypanosomal antileishmanial activities. These...
American tegumentary leishmaniasis, a zoonotic disease caused by the Leishmania genus, poses significant challenges in treatment, including administration difficulty, low efficacy, and parasite resistance. Novel compounds or associations offer alternative therapies, natural products such as oregano essential oil (OEO), extracted from Origanum vulgare, have been extensively researched due to biological effects, antibacterial, antifungal, antiparasitic properties. Silver nanoparticles (AgNp),...
The new pyrido[2,3- d ]pyridazine-2,8-dione 7c showed potential anti-inflammatory activity as a COX-1/COX-2 dual inhibitor.