A5076254936- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Pharmacogenetics and Drug Metabolism
- Sports injuries and prevention
- Tendon Structure and Treatment
- Heavy Metal Exposure and Toxicity
- Reproductive System and Pregnancy
- Shoulder Injury and Treatment
- Mercury impact and mitigation studies
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Scoliosis diagnosis and treatment
- Inflammatory mediators and NSAID effects
- Air Quality and Health Impacts
- Sports Performance and Training
- Folate and B Vitamins Research
- Radiopharmaceutical Chemistry and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Carcinogens and Genotoxicity Assessment
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Hormonal Regulation and Hypertension
- Cardiovascular Effects of Exercise
- Analytical Methods in Pharmaceuticals
- Genetic Associations and Epidemiology
Universidade do Estado do Rio de Janeiro
2022-2025
Fundação Oswaldo Cruz
2016-2025
Escola Nacional de Saúde Pública
2015-2024
Instituto Nacional de Traumatologia e Ortopedia
2016-2023
Universidade Estadual da Zona Oeste
2014-2022
Instituto Nacional do Câncer
2005-2015
Universidade Federal do Rio de Janeiro
2005
Inserm
1986
Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity regional color categories correlated with ancestry. Using a panel 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually European, African Amerindian ancestry components 934 self-categorized White, Brown or Black Brazilians from...
Abstract Objectives: to describe the epidemiological and clinical profile of women with endometriosis determine association prognostic characteristics disease. Methods: retrospective descriptive study involving 237 attended at two referral hospitals for endometriosis, between 2011 2017. Associations groups were estimated using logistic regression models. Results: most (65.4%) reproductive age (29-39 years), a body mass index in range 18.5-24.9 kg/m2 high prevalence (23-81%) symptoms disease,...
Abstract Background Musculoskeletal injuries (MSK-I) are a serious problem in sports medicine. Modifiable and non-modifiable factors associated with susceptibility to these injuries. Thus, the aim of this study was describe prevalence identify MSK-I, including tendinopathy joint muscle injuries, athletes. Methods In cross-sectional observational study, 627 athletes from rugby ( n = 225), soccer 172), combat 86), handball 82) water polo 62) were recruited at different training centres...
The Amazonian indigenous peoples depend on natural resources to live, but human activities' growing impacts threaten their health and livelihoods. Our objectives were present the principal results of an integrated multidisciplinary analysis parameters assess mercury (Hg) exposure levels in populations Brazilian Amazon. We carried out a cross-sectional study based census three Munduruku villages (
Dermal wound healing involves a cascade of complex events including angiogenesis and extracellular matrix remodeling. Several groups have focused in the study skin activity natural products. The phytomedicine Acheflan®, its main active constituent is oil from Cordia verbenacea which has known anti-inflammatory, analgesic antimicrobial activities. To our knowledge, no investigation evaluated effect Acheflan® an experimental model healing. present explored property compared it with topical...
Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels outcomes. The aim this review was to describe research discuss evidence genetic susceptibility Hg-exposed individuals development neurocognitive disorders. A systematic performed identify genes/SNPs toxicokinetics that, therefore, affect neurological function in exposed populations. Observational...
Among the processes involved in breast tumor microenvironment, angiogenesis and inflammation play a central role, main factors of these are vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) macrophages. Recently, extract Euterpe oleracea (açaí), fruit that is widely found Amazon region, already showed antitumorigenic effects vitro human cancer cell lines. The present study aimed to investigate effect açaí on using chemically DMBA (7,12-dimethylbenzanthracene) experimental...
This study investigated the therapeutic potential of Euterpe oleracea extract (açaí) on growth and survival endometriotic lesions using an experimental model. Twenty female Sprague-Dawley rats were randomized into two groups after implantation establishment autologous endometrium onto peritoneum abdominal wall treated with 200 mg/kg hydroalcoholic solution from açaí stone or vehicle via gastric tube for 30 consecutive days. Body weight, lesion surface areas, histological immunohistochemistry...
During the pandemic of COVID-19, phylogenetic changes have been observed in characteristics virus, diagnosis and treatment disease. The clinical course severe form disease depends on several factors. This study characterized beginning setting for patient care COVID-19 a referral center one main capital cities Brazil. In addition, were evaluated factors associated with mortality, length stay, diagnostic outcome.A cross-sectional was conducted during May 2020 (n = 1100). association variables...
There is controversy regarding the association between CYP4F2 rs2108622 (V33M) polymorphism and warfarin dose requirement in white patients, there are no data for nonwhite populations. We observed self-identified white, black, or "intermediate" Brazilian patients (n = 370). The addition of genotype as a variable has only marginal effect on predictive power dosing algorithm derived from this patient cohort. conclude that prospective genotyping not justified Brazilians who potential candidates...
Aim: Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. Methods: Patients receiving low (≤20 mg/week; n = 180) or high stable doses (≥42.5 187) genotyped with Affymetrix Axiom® Biobank arrays. Imputation was carried out using data from 1000 Genomes project. Results: Genome-wide signals (p ≤ 5 × 10-8) identified well-known VKORC1 (lead SNP, rs749671; OR: 20.4; p 1.08 10-33)...
Environmental and occupational exposure to benzene from fuels is a major cause for concern national international authorities, as known carcinogen in humans there no safe limit carcinogens. The objective of this study was evaluate the genotoxic effects chronic among two groups workers: filling station workers (Group I) security guards working at vehicles entrances II), both on same busy highway Rio de Janeiro, Brazil. Sociodemographic data were evaluated; concentration benzene/toluene (B/T)...
Genetic polymorphisms may be involved with mercury levels and signs symptoms of intoxication from this exposure. Therefore, the aims were to describe frequency GSTP1 polymorphism evaluate its effects on neurological in three Munduruku indigenous villages Brazilian Amazon. One-hundred-and-seven (over 12 years old) included genotyped (rs1695) using a TaqMan validated assay. Then, associations evaluated by binary logistic regression, odds ratios (OR) 95% confidence intervals (CI). Mean age was...
Sarcomas represent a heterogeneous group of malignancies characterized by varying clinical behaviors and treatment responses. Liquid biopsy has emerged as promising non-invasive method for monitoring tumor dynamics detecting actionable mutations in cancer patients. The emergence circulating DNA biomarker offers avenues improving diagnostic accuracy sarcoma In this study, the authors employed mutation-specific droplet digital PCR (ddPCR) to analyze tumor-derived cell-free DNA, also known...
Developmental dysplasia of the hip (DDH) is a multifactorial and polygenic abnormal joint development, with prognosis influenced by environmental genetic factors, potentially leading to complete dislocation. Growth differentiation factor 5 signaling molecule, encoded polymorphic gene (GDF5), promoting repair, maintenance bone, cartilage, other synovial tissues. The GDF5 rs143384 G>A polymorphism affects expression may be associated susceptibility DDH. aim this study was determine...
Our objective was to evaluate the influence of cytochrome P450 (CYP) 2C9 polymorphisms on pharmacokinetics and pharmacodynamics nonsteroidal anti-inflammatory drug piroxicam.Thirty-five healthy subjects with CYP2C9 genotypes *1/*1 (n=17), *1/*2 (n=9), *1/*3 (n=9) received a single oral dose piroxicam (20 mg). Blood samples were collected at various time points up 240 hours for measurements concentrations thromboxane B2 (TXB2).Piroxicam's area under plasma concentration-time curve from 0...
Objective: To compare the effectiveness of self-identified ethnic/color and marker-based biogeographical ancestry classifications in genotyping CYP3A5*3 polymorphism Brazilian population. Methods: Individual DNA from 308 healthy Brazilians, as white, intermediate black was genotyped for a set insertion–deletion polymorphisms, validated informative markers (AIMs). The Structure software used to analyze AIMs data obtain estimates African component (ACA). Nonlinear logistic regression modeling...
This is the first report of distribution TPMT and NUDT15 single nucleotide polymorphisms metabolic phenotypes associated with cytotoxicity thiopurine drugs, in indigenous groups Brazilian Amazon: Munduruku, Paiter-Suruí Yanomami. The minor allele frequency (MAF) rs116855232 did not differ significantly across groups; rs1800462 was absent, while rs1800460 rs1142345 were strong linkage disequilibrium, 10- 30-fold more common Paiter-Suruí. Indeed, MAFs Paiter-Surui (0.193 0.188) are largest...