A5048733514- Adipokines, Inflammation, and Metabolic Diseases
- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Pharmacogenetics and Drug Metabolism
- Stress Responses and Cortisol
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Malaria Research and Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Science and Education Research
- Nitric Oxide and Endothelin Effects
- Bioactive Compounds and Antitumor Agents
- Pharmacology and Obesity Treatment
- Essential Oils and Antimicrobial Activity
- Renin-Angiotensin System Studies
- Hemoglobinopathies and Related Disorders
- Sepsis Diagnosis and Treatment
- DNA Repair Mechanisms
- Pesticide Exposure and Toxicity
- Immune cells in cancer
- Glaucoma and retinal disorders
Centro Hospitalar Tondela-Viseu
2025
Universidade Federal de Mato Grosso
2015-2024
Universidade de Brasília
2022
Faculdades Integradas de Cacoal
2022
Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo
2022
Universidade Estadual de Santa Cruz
2004-2016
Universidade Federal de Minas Gerais
2004-2012
Universidade de São Paulo
2003-2006
Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity regional color categories correlated with ancestry. Using a panel 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually European, African Amerindian ancestry components 934 self-categorized White, Brown or Black Brazilians from...
Traditional knowledge is an important source of obtaining new phytotherapeutic agents. Ethnobotanical survey medicinal plants was conducted in Nossa Senhora Aparecida do Chumbo District (NSACD), located Poconé, Mato Grosso, Brazil using semi-structured questionnaires and interviews. 376 species belonging to 285 genera 102 families were cited. Fabaceae (10.2%), Asteraceae (7.82%) Lamaceae (4.89%) are greater importance. Species with the relative importance Himatanthus obovatus (1.87),...
The failure of neutrophils to migrate an infection focus during severe sepsis is important determinant the inability a host deal with infectious insult. Our laboratory has shown that inducible nitric oxide synthase (iNOS) induction and NO production contribute in context sepsis.We investigated whether CXCR2 expression contributed role modulating on mice subjected nonsevere (NS) or (S) cecal ligation puncture (CLP).Neutrophil migration was deficient S-CLP mice, phenomenon prevented by...
Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx the Latin American and Caribbean (LAC) region remains scarce, with limited information some populations. Thus, extrapolations are complicated, especially mixed In this paper, we reviewed analyzed pharmacogenomic knowledge among LAC scientific clinical community examined barriers to application. We performed a search for publications trials worldwide evaluated contribution of LAC. Next, conducted...
Chronic low-grade inflammation is related to the development of comorbidities and poor prognosis in obesity. Monocytes are main sources cytokines play a pivotal role inflammation. We evaluated monocyte frequency, phenotype cytokine profile subsets, determine their association with pathogenesis childhood Children obesity were for biochemical anthropometric parameters. Monocyte subsets characterized by flow cytometry, considering production activation/recognition molecules. Correlation...
Natural products comprise valuable sources for new antiparasitic drugs. Here we tested the effects of a novel β-lapachone derivative on Trypanosoma cruzi parasite survival and proliferation used microscopy cytometry techniques to approach mechanism(s) underlying death. The selectivity index determination indicate that compound trypanocidal activity was over ten-fold more cytotoxic epimastigotes than macrophages or splenocytes. Scanning electron analysis revealed R72 affected T. morphology...
Abstract Introduction Understanding and critically examining mortality in the coronary intensive care unit (CICU) is essential to ensure high-quality care. With advancements healthcare technology, people are living longer, posing new challenges, particularly defining limits of medical intervention recognizing when a situation irreversible, with shift needed toward comfort-focused Purpose This study aimed analyze four-year trends CICU, focusing on epidemiology, sociodemographic...
Abstract Introduction Spontaneous coronary dissection (SCAD), although rare, is a significant cause of acute syndrome (ACS) in young patients, particularly women without notable risk factors. Due to the limited number cases reported literature and scarcity prospective studies, uncertainties remain regarding most appropriate therapeutic approach. Observational studies small sample sizes suggest benefit adopting conservative strategy, reserving revascularization for with ongoing ischemia,...
Abstract Sepsis is a systemic inflammatory response that results from the inability of immune system to limit bacterial spread during an ongoing infection. Recently, we have documented impaired neutrophil migration toward infectious focus in severe sepsis. This impairment seems be mediated by circulating cytokines, chemokines, and NO. Platelet-activating factor (PAF) plays important role orchestration different reactions, including release free radicals. Using PAFR antagonist, PCA-4248,...
Neutrophil migration to an infectious focus is essential for control and resolution of infection. Early studies demonstrated that the failure such observed in lethal sepsis induced by cecal ligation puncture (L-CLP), whereas intense neutrophil seen sublethal CLP (SL-CLP). In this study, we found inhibition synthesis prostaglandins or leukotriene B4 (LTB4) did not modify survival rate L-CLP mice. addition, pretreatment mice with a platelet activating factor (PAF) receptor antagonist...
JUSTIFICATIVA E OBJETIVOS: Os antiinflamatórios não-esteroidais (AINE) estão entre as drogas mais prescritas e usadas no mundo, incluindo a utilização em Anestesiologia. O propósito desta revisão é discutir alguns aspectos atuais da bioquímica ciclooxigenase, que vem servindo de base para o desenvolvimento dos novos AINE. CONTEÚDO: Estas exercem suas ações principalmente através inibição ciclooxigenase (COX), enzima chave catalisa conversão ácido araquidônico prostaglandinas tromboxanos....
Recent pharmacogenomic studies have revealed significant interethnic differences in glutathione S-transferase (GST) allelic frequencies among various ethnic groups. Therefore, we investigated <i>GSTM1</i> (gene deletion), <i>GSTT1 </i>(gene deletion) and <i>GSTP1</i> (rs1695) polymorphism 3 Brazilian groups (n = 203). <i>GSTM1 </i>and </i>polymorphism analyses were performed by multiplex polymerase chain reaction, analysis was done...
The aim of this study was to compare the anthropometric, biochemical, and hormonal characteristics presence genetic polymorphisms leptin, adiponectin, tumor necrosis factor alpha (TNF-α) between eutrophic obese children adolescents.This is a case-control involving 104 adolescents. All subjects were assessed for anthropometric clinical, laboratory, polymorphism parameters. sample selected from pediatric endocrinology outpatient clinic specialized in treatment obesity adolescents according...