A5034509008- Pharmacogenetics and Drug Metabolism
- Glutathione Transferases and Polymorphisms
- Computational Drug Discovery Methods
- Nutrition, Genetics, and Disease
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Treatments and Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Antibiotics Pharmacokinetics and Efficacy
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Carcinogens and Genotoxicity Assessment
- Biosimilars and Bioanalytical Methods
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- Helicobacter pylori-related gastroenterology studies
- Atrial Fibrillation Management and Outcomes
- Inflammatory mediators and NSAID effects
- SARS-CoV-2 detection and testing
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
University of Chile
2016-2025
Facultad Latinoamericana de Ciencias Sociales
2021
Universidad UTE
2020
United Nations Economic Commission for Latin America and the Caribbean
2019
Hospital Vargas
2015
Mindanao State University – Iligan Institute of Technology
2015
Sri Siddhartha Medical College
2015
Fulcrum Corporation (United States)
2014
Center for Environmental Health
2014
Faculty of Public Health
2014
Oxidative stress is implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In present study, hepatic and plasma oxidative stress-related parameters were measured correlated with clinical histological findings 31 NAFLD patients showing increased body mass index. Liver protein carbonyl content was enhanced by 403% steatosis (n=15) compared control values (n=12), whereas glutathione content, superoxide dismutase (SOD) activity ferric reducing ability (FRAP) decreased 57%,...
Cancer is a leading cause of death worldwide. The cancer incidence rate in Chile 133.7/100,000 inhabitants and it the second death, after cardiovascular diseases. Most antineoplastic drugs are metabolized to be detoxified, some them activated. Genetic polymorphisms drug-metabolizing enzymes can induce deep changes enzyme activity, individual variability drug efficacy and/or toxicity. present research describes presence genetic Chilean population, which might useful public health programs for...
Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx the Latin American and Caribbean (LAC) region remains scarce, with limited information some populations. Thus, extrapolations are complicated, especially mixed In this paper, we reviewed analyzed pharmacogenomic knowledge among LAC scientific clinical community examined barriers to application. We performed a search for publications trials worldwide evaluated contribution of LAC. Next, conducted...
Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations long-COVID. This lung affection has been associated with disease severity during acute phase and presence previous comorbidities, however, clinical manifestations, concomitant consequences molecular pathways supporting this condition remain unknown. The aim study was to identify characterize L-TPD in patients long-COVID elucidate main long-term attributed by analyzing parameters functional tests supported...
Introduction: Gastric cancer is one of the most prevalent types worldwide. The World Health Organization (WHO), International Agency for Research on Cancer (IARC), and Global Statistics (GLOBOCAN) reported an age standardized global incidence rate 9.2 per 100,000 individuals gastric in 2022, with a mortality 6.1. Despite considerable progress precision oncology through efforts international consortia, understanding genomic features their influence effectiveness anti-cancer treatments across...
To assess the role of several genetic factors in combination with an environmental factor as modulators prostate cancer risk. We focus on allele variants low-penetrance genes associated cell control, detoxification processes and smoking.In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 GSTM1 null genotypes their risk.The joint risk for smokers Pro* M1*, GSTM1null or M1* was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36;...
Prognostic markers for cancer can assist in the evaluation of survival probability patients and help clinicians to assess available treatment modalities. Gallbladder (GBC) is a rare tumor that causes 165 087 deaths world annually. It most common biliary tract has particularly high incidence Chile, Japan, northern India. Currently, there no accurate diagnosis test or effective molecular GBC identification. Several studies have focused on discovery genetic alterations important genes...
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing human tissues, artificial neural networks reveal potential for drug repurposing against COVID-19. Results: screened 1,584 high-confidence proteins ACE2 TMPRSS2 co-expressing cells, finding 25 significantly overexpressed nasal goblet secretory lung...
Abstract Introduction Gastric cancer (GC) is one of the most lethal malignancies worldwide. Helicobacter pylori primary cause GC; therefore, its eradication reduces risk developing this neoplasia. There extensive evidence regarding quadruple therapy with relevance to European population. However, in Latin America, data are scarce. Furthermore, there limited information about rates achieved by antibiotic schemes and American populations. Objective To compare effectiveness standard triple...
Pharmacogenetics and Pharmacogenomics areas are currently emerging fields focused to manage pharmacotherapy that may prevent undertreatment while avoiding associated drug toxicity in patients. Large international differences the awareness use of pharmacogenomic testing presumed, but not well assessed date. In present study we review Latin American scientific community about perceived barriers for their clinical application. order that, have compiled information from 9 countries region using...
The urinary arsenic metabolites may vary among individuals and the genetic factors have been reported to explain part of variation. We assessed influence polymorphic variants Arsenic-3-methyl-transferase Glutathione-S-transferase on metabolites. Twenty-two groundwater wells for human consumption from municipalities Colombia were analyzed exposure by lifetime average daily dose (LADD) (µg/kg bw/day). Surveys 151 participants aged between 18 81 years old applied collect demographic information...
Colorectal cancer is a common disease, both in Chile and worldwide. The most widely used chemotherapy schemes are based on 5-fluorouracil (5FU) as the foundational drug (FOLFOX, CapeOX). Genetic polymorphisms have emerged potential predictive biomarkers of response to chemotherapy, but conclusive evidence lacking. This study aimed investigate role genetic variants associated with 5FU-based therapeutic response, considering their interaction oncogene mutations (KRAS, NRAS, PI3KCA, AKT1,...
114 Background: Colorectal cancer (CRC) ranks as the second most common in Chile, affecting both men and women. Late diagnosis results approximately 25% of patients presenting with metastatic disease, a five-year survival rate about 14%. Standard treatment includes tumor resection followed by adjuvant chemotherapy, commonly involving 5-fluorouracil (5-FU) combined drugs like oxaliplatin or irinotecan. However, patient responses to 5-FU vary greatly due genetic polymorphisms enzymes...
Background/Objectives: Pain management in colorectal cancer is influenced by genetic variability opioid receptor genes (OPRM1 and OPRD1), potentially affecting efficacy adverse drug reactions (ADRs). This study evaluated the association of OPRM1 (rs1799971 rs510769) OPRD1 (rs2236861) polymorphisms with pain severity, efficacy, ADRs Chilean patients. Methods: The genotypes clinical data from 69 patients were analyzed. Associations between genotypes, ADRs, severity (maximum Visual Analog...
The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates detoxification these metabolites by conjugating them with glutathione. presence CYP1A1*2A genetic variant intensifies production metabolites, and deletion gene ( GSTM1*0 ) impairs their detoxification. This enzymatic imbalance leads to formation DNA adducts, which are known contribute cancer other diseases. Given importance studying...
Background/Objective: Vancomycin, a hydrophilic glycopeptide antibiotic with bactericidal activity against gram-positive microorganisms, is one of the most used antibiotics at intensive care units (ICU). Different efforts have been done to achieve therapeutically effective plasma concentration vancomycin by using loading and subsequent maintenance doses on an individual basis, but this remains debate. Our objective was individualize dosage regimen in Chilean ICU optimize pharmacological...
Background/Objective: Vancomycin, a hydrophilic glycopeptide antibiotic with bactericidal activity against Gram-positive microorganisms, is one of the most commonly used antibiotics un intensive care unit (ICU). Different efforts have been made to achieve therapeutically effective plasma concentration vancomycin by using loading and subsequent maintenance doses on an individual basis, but this remains subject debate. Our objective was individualize dosage regimen in Chilean ICU optimize...