A5062863015- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Salivary Gland Disorders and Functions
- Animal Virus Infections Studies
- Inflammasome and immune disorders
- Viral gastroenteritis research and epidemiology
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Immunodeficiency and Autoimmune Disorders
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Diabetes and associated disorders
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Digital Accessibility for Disabilities
- SARS-CoV-2 detection and testing
- Immune cells in cancer
- Steroid Chemistry and Biochemistry
- Reproductive System and Pregnancy
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diverse Scientific Research Studies
- Protein Degradation and Inhibitors
Universidad de Las Américas
2019-2025
Karolinska Institutet
2017-2025
Karolinska University Hospital
2017-2020
National and Kapodistrian University of Athens
1975-2015
National Centre of Scientific Research "Demokritos"
1975
Abstract Hyperactivation of YAP/TAZ, the Hippo pathway downstream effectors, is common in human cancer. The requirement YAP/TAZ for cancer cell survival preclinical models, prompted development pharmacological inhibitors that suppress their transcriptional activity. However, systemic inhibition may sometimes have unpredictable patient outcomes, with limited or even adverse effects because action not simply tumor promoting but also suppressive some types. Here, we review role distinct...
Coronaviruses are an extensive family of viruses that can cause disease in both animals and humans. The current classification coronaviruses recognizes 39 species 27 subgenera belong to the Coronaviridae. From those, at least seven known respiratory infections Four these common cold-like symptoms, while others infect evolve become infectious Three recent examples this viral jumps include SARS CoV, MERS-CoV CoV-2 virus. They responsible for causing severe acute syndrome (SARS), Middle East...
The elevated tissue expression of Ro/SSA and La/SSB autoantigens appears to be crucial for the generation perpetuation autoimmune humoral responses against these in Sjögren's syndrome (SS). mechanisms that govern their are not known. miRNAs, post-transcriptional regulators gene expression, might implicated. We have identified previously miRNAs let7b, miR16, miR181a, miR200b-3p, miR200b-5p, miR223 miR483-5p predicted target [Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE...
Summary Up-regulated expression of Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE domain family, member 2 (TROVE2) and lupus LA protein/Sjögren's syndrome antigen B (La/SSB) autoantigens has been described in the salivary gland epithelial cells (SGEC) patients with Sjögren's (SS). SGECs, key regulators autoimmune SS responses, express high levels surface functional Toll-like receptor (TLR)-3, whereas Ro52/TRIM21 negatively regulates TLR-3-mediated inflammation. Herein, we...
BACKGROUND: The Andean blackberry (Rubus glaucus Benth) is one of Ecuador’s most iconic berries for which a high anthocyanin content has been described. OBJECTIVE: aim the present study was to determine chemical composition and anti-inflammatory potential from Ecuador, with an emphasis on its effects NLRP3 inflammasome activation autophagy processes. RESULTS: extracts were rich in hydroxycinnamates (coumaric acid derivates), addition quercetin kaempferol as principal flavonols. Cyanidin...
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing human tissues, artificial neural networks reveal potential for drug repurposing against COVID-19. Results: screened 1,584 high-confidence proteins ACE2 TMPRSS2 co-expressing cells, finding 25 significantly overexpressed nasal goblet secretory lung...
Congenital heart block (CHB), a manifestation of neonatal lupus, is associated with maternal anti-Ro/SSA and anti-La/SSB autoantibodies recurs in ∼18% subsequent pregnancies. This study was undertaken to investigate the effect idiotype:antiidiotype (Id:anti-Id) antibody ratio ability intravenous immunoglobulin (IVIG) administered during pregnancies prevent CHB.We studied 16 anti-La/SSB-positive pregnant women from Preventive IVIG Therapy for Heart Block who had previously given birth child...
Chicken meat production has expanded considerably on a global scale due to its ease of compared other species. As result, the prevalence avian viruses grown. astrovirus (CAstV), an RNA virus with roughly 7 kb in length that is disseminated globally and exhibits both horizontal vertical transmission, one most important enteric pathogenic viruses. CAstV some viruses' infections causes significant economic losses because they are associated high mortality chickens. cause variety pathologic...
Objective In utero exposure of the fetus to Ro/La autoantibodies may lead congenital heart block (CHB). mother, these are associated with activation type I interferon (IFN)-system. As maternal transferred during pregnancy, we investigated whether IFN-system is activated also in newborns anti-Ro/La positive mothers, and fetal IFN affected by immunomodulatory treatment. Methods Blood drawn at birth from their healthy control pairs was separated into plasma peripheral blood mononuclear cells...
Since the beginning of COVID-19 pandemic, communication technology has demonstrated its usefulness in sharing and receiving health data communicating with public. This study evaluated accessibility 199 websites containing official information related to medical schools, governments, ministries, associations, obtained from Geneva Foundation for Medical Education Research website. We used Web Content Accessibility Guidelines 2.1 evaluate web accessibility, using a six-phase process an...
Enteric viruses are among the most prominent etiological agents of Runting-Stunting Syndrome (RSS). The Avian Nephritis Virus (ANV) is an astrovirus associated with enteric diseases in poultry, whose early diagnosis essential for maintaining a good poultry breeding environment. ANV RNA virus that rapidly mutates, except some conserved regions such as ORF1b. Therefore, approach diagnostic method based on fast-RT-qPCR using SYBR® Green focuses amplification fragment ORF1b presented feasible...
DNA oncoviruses represent an intriguing subject due to their involvement in oncogenesis. These viruses have evolved mechanisms manipulate the host immune response, facilitating persistence and actively contributing carcinogenic processes. This paper describes complex interactions between innate system, with a particular emphasis on cGAS-STING pathway. Exploring these highlights that strategically target subvert this pathway, exploiting its vulnerabilities for own survival proliferation...
Background Although RT-qPCR remains the gold-standard for COVID-19 diagnosis, anti-SARS-CoV-2 serology-based assays have been widely used during 2020 as an alternative individual and mass testing, are currently seroprevalence studies. Objective To study clinical performance of seven commercial serological tests diagnosis available in South America. Methods We conducted a blind evaluation five lateral-flow immunoassays (LFIA) two enzyme-linked immunosorbent (ELISAs) detecting antibodies....
Systemic lupus erythematosus (SLE) is characterized by the production of grouped sets autoantibodies targeting mainly U1 ribonucleoprotein (RNP) and/or Ro/La RNP particles. Intraparticle diversification autoimmune response believed to occur via epitope spreading. So far, it not known how "jumps" from one particle another. To extent that majority nuclear autoantigens in SLE are RNA binding proteins and major epitopes were previously mapped within their RRM (RNA recognition motifs), conserved...
White chick syndrome (WCS) is an emergent disease that affects hatchability and hatched chicks, resulting in high mortality economic losses, related to chicken astrovirus (CAstV). This has been reported several countries worldwide, groups A iii B vi of CAstV have determined; however, Brazil, the virus not genotyped. The innate immunity chicks affected by WCS or any poorly understood studied, it important determine whether relative cytokine expression occurs during early stages life chicks....
Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-19. Respiratory failure the main cause death in COVID-19 patients, and host inflammatory response at lungs remains poorly understood. Methods: Therefore, we retrieved data from post-mortem patients performed in-depth silico analyses single-nucleus RNA sequencing data, protein interactome network, shortest pathways physiological phenotypes reveal potential therapeutic targets advanced-stage clinical...