A5006452787- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Advanced Chemical Sensor Technologies
- Heavy Metal Exposure and Toxicity
- Analytical Chemistry and Chromatography
- Chemical Safety and Risk Management
- Metabolomics and Mass Spectrometry Studies
- Pesticide Residue Analysis and Safety
- Pesticide Exposure and Toxicity
- Analytical chemistry methods development
- Electrochemical Analysis and Applications
- Tailings Management and Properties
- Indoor Air Quality and Microbial Exposure
- Recycling and Waste Management Techniques
- Heavy metals in environment
- Air Quality and Health Impacts
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- thermodynamics and calorimetric analyses
- Antibiotics Pharmacokinetics and Efficacy
- Mercury impact and mitigation studies
- Clostridium difficile and Clostridium perfringens research
- Water-Energy-Food Nexus Studies
- Genetically Modified Organisms Research
Universidade Federal de Minas Gerais
2015-2024
Long-term sequelae of coronavirus disease (COVID)-19 are frequent and major concern. Severe acute respiratory syndrome 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to severity in patients with COVID-19. Here, we report that microbiota post-COVID subjects had a remarkable predominance Enterobacteriaceae strains an antibiotic-resistant phenotype compared healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced feces. Fecal transplantation...
Phthalates used as plasticizers in the manufacture of household containers can potentially be transferred to foods that are stored or heated these plastic containers. endocrine disruptor compounds (EDC) and found very low concentrations foods, thus, highly sensitive analytical techniques required for their quantification. This study describes application a new method developed analyzing migration dibutylphthalate (DBP) benzylbutylphthalate (BBP) from food into liquid simulants. employs...
Environmental and occupational exposure to benzene from fuels is a major cause for concern national international authorities, as known carcinogen in humans there no safe limit carcinogens. The objective of this study was evaluate the genotoxic effects chronic among two groups workers: filling station workers (Group I) security guards working at vehicles entrances II), both on same busy highway Rio de Janeiro, Brazil. Sociodemographic data were evaluated; concentration benzene/toluene (B/T)...
Abstract Mucositis is an inflammation of the gastrointestinal mucosa resulting from high doses radio/chemotherapy treatment and may lead to interruption antineoplasic therapy. Soluble fibres, like pectin, increase SCFA production, which play a role in gut homoeostasis suppression. Due properties aim present study was evaluate effect high-fibre (HF) diet on chemotherapy-induced mucositis murine model. C57/BL6 mice received control (AIN93M), HF, low/zero fibre (LF) diets for 10 d prior...
Benzene is a human carcinogen whose exposure to concentrations below 1 ppm (3.19 mg·m-3) associated with myelotoxic effects. The determination of biomarkers such as trans-trans muconic acid (AttM) and S-phenylmercapturic (SPMA) show without reflecting the toxic effects benzene. For this reason, in study, urinary metabolome individuals exposed low benzene was investigated, aim understanding biological response xenobiotic identifying metabolites correlated induced by it. Ultra-efficient liquid...
Ameloblastoma is a locally infiltrative, aggressive epithelial odontogenic neoplasm. BRAF-V600E mutation frequently found in this tumor and has pivotal role its pathogenesis, but the consequences of alteration need to be addressed. An untargeted metabolomics approach was applied verify whether metabolic disturbances are related biology contributes these alterations.Formalin-fixed paraffin-embedded tissue specimens from thirteen ameloblastoma six dental follicles were included study. BRAF...
BACKGROUND Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level virulence. OBJECTIVES We reported L. biology including glycoconjugates, proteolytic activities and metabolome composition comparison pathogenic (Leishmania amazonensis, braziliensis, infantum major). METHODS Parasites were cultured extraction purification lipophosphoglycan (LPG),...
Resumo Introdução: trabalhadores estão sujeitos a riscos decorrentes da exposição ambiental e ocupacional ao benzeno, situação ainda mais crítica quando associada fatores como desigualdade social, múltipla exposição, suscetibilidade individual, degradação às possíveis interações entre os contaminantes ambientais. Além disso, nem sempre as regulamentações são estabelecidas e/ou atualizadas apenas partir de achados científicos, pois processos permeados por conflitos interesses. Objetivo:...
Pesticides constitute a category of chemical products intended specifically for the control and mitigation pests. With their constant increase in use, risk to human health environment has increased proportionally due occupational environmental exposure these compounds. The use chemicals is associated with several toxic effects related acute chronic toxicity, such as infertility, hormonal disorders cancer. present work aimed study metabolic profile individuals occupationally exposed...
Resumo Introdução: a avaliação de uma exposição mensura sua intensidade, frequência e duração, podendo detectar danos precoces que, se ignorados, podem evoluir para um quadro nocivo. Nos campos da saúde ambiental ocupacional, os biomarcadores genotoxicidade tem sido largamente utilizados essa avaliação. Objetivo: identificar, descrever discutir principais bioindicadores seu uso conjunto com técnicas expressão gênica em estudos ocupacional ao benzeno postos revenda combustíveis (PRC)....
The present study describes an efficient analytical method for analyzing apple pesticide residues. This novel approach employs ultrasound-assisted cleaning (UAC), solid-phase microextraction (SPME), and gas chromatography/mass spectrometry (GC-MS). A fiber coating with carbon nanomaterials (CNMs) was used the extraction process. methodology underwent process optimization validation. Moreover, its applicability detecting pesticides in apples evaluated. validation showed satisfactory results...
Background Oral Lichen Planus is a chronic inflammatory disorder that affects the oral mucosa, with reticular and erosive forms representing primary clinical variants of disease. Previous studies have shown metabolic alterations may well be involved in pathogenesis disease; however, molecular mechanisms related to clinicopathological differences between remain unknown. Methods A comparative metabolomic analysis was performed on formalin‐fixed paraffin‐embedded tissue samples (n = 6) 10)...
Abstract Habitat loss and fragmentation are among the greatest threats to biodiversity ecosystem stability, with physiological implications on wild fauna. Bats (Microchiroptera) small mammals a wide variety of eating habits, well-being these animals is disturbed by exposure pesticides. This study aimed develop miniaturized QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) extraction method for detection multi-residue pesticides in bat muscle tissue using gas chromatography coupled mass...
Comprehensive two-dimensional gas chromatography has been successfully applied to the analysis of various organic contaminants; however, few studies report its use in endocrine disrupting compounds.These compounds are suspected cause dysfunction system humans and animals.This work describes development a method analyse dibutylphthalate, benzylbutylphthalate, nonylphenol octylphenol water using solid-phase microextraction (SPME) comprehensive with flame ionisation detector.The merit...
This article describes the development and validation of a solid-phase microextraction method using direct immersion cold fiber (DI-CF-SPME) to collect samples in ambient air particulate matter gas phase analyze 16 priority polycyclic aromatic hydrocarbons by chromatography mass spectrometry. has proven yield good results for some parameters. Limits detection quantification ranged from 0.008 ng m−3 0.095 0.020 0.101 m−3, respectively. The inter-assay precision shows coefficient variation...
Resumo Introdução: frentistas e analistas de combustíveis estão expostos a vários compostos orgânicos voláteis presentes na gasolina, incluindo benzeno, que se destaca por sua importância toxicológica. Objetivo: avaliar exposição ocupacional ao benzeno utilizando o Teste Cometa como biomarcador genotoxicidade em comparação ácido trans,trans-mucônico urinário (AttM) benzeno. Métodos: estudo corte transversal com análises biomarcadores grupo ocupacionalmente através da gasolina controle....
Banana characteristics could provide yeast growth and support the action of to produce beverages. The effects enzymatic treatment, centrifugation, commercial two selected strains Saccharomyces cerevisiae were investigated using fermented banana Terra. Volatile organic compounds (VOCs) determined by solid phase microextraction gas chromatography mass spectrometry. results showed that condition employing centrifugation wet provided maximum ethanol yield (86%) effiency (98%). Twenty-two...
ABSTRACT Objective: To describe the prevalence of levels arsenic, cadmium, mercury, lead and manganese above reference values (RV) in population Brumadinho, after rupture mining tailings dam to verify factors associated with these levels. Methods: Baseline study a prospective cohort, representative sample 3,080 residents (aged 12 over) Minas Gerais. Exploratory variables (age, sex, skin color, household income, smoking place residence) were collected using questionnaire As, Cd Hg urine Pb Mn...
Resumo Introdução: o benzeno é uma substância de reconhecida toxicidade e sua biomonitorização torna-se fundamental para a prevenção danos à saúde humana, principalmente em situações exposição ocupacional. Dentre os biomarcadores exposição, ácido S-fenilmercaptúrico considerado único específico, mas, devido suas baixas concentrações na urina, requerido uso técnicas analíticas sensíveis capazes quantificar traços. Objetivo: revisar metodologias baseadas cromatografia espectrometria massas...