A5080873352- Bone fractures and treatments
- Sarcoma Diagnosis and Treatment
- TGF-β signaling in diseases
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Dental Implant Techniques and Outcomes
- Tendon Structure and Treatment
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Parathyroid Disorders and Treatments
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Shoulder Injury and Treatment
- Oral microbiology and periodontitis research
- Total Knee Arthroplasty Outcomes
- Cervical Cancer and HPV Research
- Bone health and osteoporosis research
- Hip disorders and treatments
- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- COVID-19 and healthcare impacts
- Bone and Dental Protein Studies
- Vitamin D Research Studies
- Genital Health and Disease
D’Or Institute for Research and Education
2023-2025
Instituto Nacional de Traumatologia e Ortopedia
2013-2023
Universidade Federal do Rio de Janeiro
2009-2023
North Carolina State University
2023
Escola Superior de Saúde Egas Moniz
2023
National Institute of Traumatology & Orthopaedic Rehabilitation
2017
Universidade Federal Fluminense
1998-2011
Hemorio
2008
Universidade do Estado do Rio de Janeiro
2004-2005
Universidade Federal do Ceará
2003
: The aim of this study was to evaluate the presence periodontopathogens in subgingival periimplant sites partially edentulous patients using polymerase chain reaction procedures, with regard areas clinical and radiographic signs health presenting disease.: Thirty nonsmoking, patients, aged 30 76 years, were included divided 3 groups according their characteristics. Group A (n = 10) presented health, group B mucositis, C periimplantitis. Periimplant tissues clinically examined as regards...
Recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier induces for reconstruction of skeletal defects. The rhBMP-2/ACS implant is prepared by administering a rhBMP-2 solution to dry ACS. Once prepared, forms moldable, cohesive, and adhesive implant. However, does not have sufficient structural strength withstand soft tissue compression at specific anatomic sites. To more fully understand the mechanisms that affect induction presence...
To analyze the interleukin (IL)-1β and IL-10 expressions in periimplant crevicular fluid (PICF) healthy diseased regions to elucidate inflammatory process around implants its influence on clinical diagnosis.PICF samples from 30 patients were analyzed for IL-1β concentrations by enzyme-linked immunosorbent assay. Patients divided Groups A (health), B (mucositis), C (periimplantitis). Plaque accumulation, periodontal phenotype (PP), depth probing, history of periodontitis (HP) evaluated.IL-1β...
The success rates in implant dentistry vary significantly among patients presenting previous history of periodontitis. aim this study was to evaluate if with chronic periodontitis (CP) are more susceptible peri-implant disease (PID) than those without CP. Two hundred and fifteen individuals, under periodontal maintenance, 754 osseointegrated implants, were selected for study. divided into two groups according the status: Control group (patients PID; n=129) PID n=86). All regions clinically...
To investigate the association between interleukin-6 (IL-6) G174C polymorphism and susceptibility to peri-implant disease (PID) and/or chronic periodontitis (CP), in Brazilian subjects.A total of 103 patients were submitted periodontal examination. According their characteristics, divided into: group A (healthy, n = 52), B (peri-implant mucositis, 20), C (peri-implantitis, 31). All (n 103) also characterized as healthy periodontium without CP (HP, 60) or (CP, 43). DNA was extracted from...
Abstract Background The repair of large bone defects is a major orthopedic challenge because autologous grafts are not available in amounts and harvesting often associated with donor-site morbidity. Considering that marrow stromal cells (BMSC) responsible for the maintenance turnover throughout life, we investigated at site critically sized segmental defect sheep tibia treated BMSCs loaded onto allografts. was created mid-portion tibial diaphysis eight adult sheep, were ex-vivo expanded...
The correlation between BMP-2 and osteosarcoma growth has gained increased interest in the recent years, however, there is still no consensus. In this study, we tested effects of on cells through both vitro vivo experiments. effect proliferation, migration invasion was vitro. Subcutaneous intratibial tumor models were used for experiments nude mice. EMT Wnt/β-catenin signaling pathway also using a variety biochemical methods. tests did not show significant cell proliferation. However,...
This study aims to build machine learning-based CT radiomic features predict patients developing metastasis after osteosarcoma diagnosis.This retrospective has included 81 with a histopathological diagnosis of osteosarcoma. The entire dataset was divided randomly into training (60%) and test sets (40%). A data augmentation technique for the minority class performed in set, along feature's selection model's training. were extracted from CT's image local Three frequently used learning models...
ABSTRACT Fracture healing is a complex process influenced by multitude of factors and expression several thousand genes. Polymorphisms in these genes can lead to an extended explain why certain patients are more susceptible develop non‐union. A total 16 SNPs within five involved bone repair pathogenesis ( FAM5C , BMP4 FGF3 FGF10 FGFR1 ) were investigated 167 with long fractures, 101 uneventful healing, 66 presenting aseptic non‐unions. Exclusion criteria pathological osteoporosis,...
Este trabalho aborda a importância da vitamina D na regulação das respostas imunes cutâneas, indo além do seu papel tradicional manutenção metabolismo ósseo. Considerando que deficiência desse nutriente tem sido relacionada doenças inflamatórias e autoimunes como psoríase dermatite atópica, objetiva-se esclarecer os mecanismos imunológicos ela desencadeia pele. Para tanto, procedeu-se uma revisão crítica literatura, abrangendo estudos publicados entre 2018 2024, com ênfase em pesquisas...
Sarcomas represent a heterogeneous group of malignancies characterized by varying clinical behaviors and treatment responses. Liquid biopsy has emerged as promising non-invasive method for monitoring tumor dynamics detecting actionable mutations in cancer patients. The emergence circulating DNA biomarker offers avenues improving diagnostic accuracy sarcoma In this study, the authors employed mutation-specific droplet digital PCR (ddPCR) to analyze tumor-derived cell-free DNA, also known...
Atipias de células glandulares em esfregaços cervicovaginais é um achado citológico na rotina rastreamento do câncer cervical, que aumentou nas últimas décadas. Sua constatação importante clinicamente, pois alta a percentagem casos associados com doença cervical e endometrial alto grau câncer. Este trabalho avaliou, por meio uma revisão sistemática, estudos investigaram o perfil das lesões colo uterino avaliações histológicas seguimento pacientes já diagnosticadas atípicas. Foram excluídos...
Tendinopathy pathogenesis is associated with inflammation. Regulatory T (Treg) cells contribute to early tissue repair through an anti-inflammatory action, the forkhead box P3 (FOXP3) transcription factor being essential for Treg function, and FC-receptor-like 3 (FCRL3) possibly negatively regulating function. FCRL3 –169T>C FOXP3 –2383C>T polymorphisms are located near elements that regulate respective genes expression, thus it was deemed relevant evaluate these as risk factors tendinopathy...