A5081070477- Drug Solubulity and Delivery Systems
- Ginkgo biloba and Cashew Applications
- Polysaccharides Composition and Applications
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Layered Double Hydroxides Synthesis and Applications
- Clay minerals and soil interactions
- Analytical Methods in Pharmaceuticals
- Trypanosoma species research and implications
- Pharmacological Effects of Natural Compounds
- HIV/AIDS drug development and treatment
- Mesoporous Materials and Catalysis
- Thermal and Kinetic Analysis
- Polysaccharides and Plant Cell Walls
- Therapeutic Uses of Natural Elements
- Leprosy Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- biodegradable polymer synthesis and properties
- Proteins in Food Systems
- Nanoparticle-Based Drug Delivery
- Biofuel production and bioconversion
- Magnesium Oxide Properties and Applications
- Agricultural and Food Sciences
- Mycobacterium research and diagnosis
Universidade Federal de Pernambuco
2016-2025
Ministério da Saúde
2024
Universidade Federal de Alagoas
2024
Centro Universitário da Cidade
2024
Universidade Federal do Piauí
2010-2013
Benznidazole (BNZ), the only commercialized antichagasic drug, and antifungal compound posaconazole (PCZ) have shown synergistic action in therapy of Chagas disease, however both active pharmaceutical ingredients (APIs) exhibit low aqueous solubility potentially limiting their bioavailability therapeutic efficacy. In this paper, we report for first time formation a eutectic mixture as well an amorphous solid solution PCZ BNZ (at same characteristic ratio 80:20 wt%), which provided enhanced...
Benznidazole (BNZ) is the drug of choice for Chagas disease treatment, which affects about 9.8 million people worldwide. It has low solubility and high toxicity. The present study aimed to develop characterize inclusion complexes (IC) in binary systems (BS) with BNZ randomly methylated-β-cyclodextrin (RMβCD) ternary (TS) BNZ, RMβCD hydrophilic polymers. results showed that solid BS had a large increase dissolution rate (Q > 80%). For IC obtained, kneading method, ratio 1:0.17 (77.8% 60 min),...
This study addresses a new application for simultaneous quantification of clofazimine (CLZ) and dapsone (DAP) in combined fixed-dose formulation evaluation their vitro release profile using UV-Vis spectroscopy, with partial least squares regression (PLS) multivariate curve resolution (MCR-ALS). High-Performance Liquid Chromatography Photodiode Array Detector (HPLC-PDA) was the reference method comparing models. Both models underwent validation external sample sets were applied to analysis...
Efavirenz (EFZ) is one of the most used drugs in treatment AIDS and first antiretroviral choice. However, since it has low solubility, does not exhibit suitable bioavailability, which interferes with its therapeutic action classified as a class II drug according Biopharmaceutical Classification System (low solubility high permeability). Among several delivery systems, multicomponent systems cyclodextrins hydrophilic polymers are promising alternative for increasing aqueous drug. The present...