A5057686719- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Seaweed-derived Bioactive Compounds
- Oral health in cancer treatment
- Fungal Biology and Applications
- Neutropenia and Cancer Infections
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- RNA regulation and disease
- Hematopoietic Stem Cell Transplantation
- Bioeconomy and Sustainability Development
- Child Nutrition and Feeding Issues
- Phytochemistry Medicinal Plant Applications
- Cynara cardunculus studies
- Parkinson's Disease Mechanisms and Treatments
- Fibroblast Growth Factor Research
- Pancreatitis Pathology and Treatment
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activity of medicinal plants
- Ion Channels and Receptors
- Pharmacological Effects of Natural Compounds
- COVID-19 Impact on Reproduction
- Piperaceae Chemical and Biological Studies
Instituto de Tecnologia do Paraná
2020-2024
Universidade de Pernambuco
2024
Instituto de Pesca
2021-2024
Universidade Federal do Paraná
2018-2022
Escherichia coli and Staphylococcus aureus are important agents of urinary tract infections that can often evolve to severe infections. The rise antibiotic-resistant strains has driven the search for novel therapies replace use or act as adjuvants antibiotics. In this context, plant-derived compounds have been widely investigated. Cuminaldehyde is suggested major antimicrobial compound cumin seed essential oil. However, effect not fully understood. Herein, we investigated in silico vitro...
The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in Ehrlich carcinoma mice and human mammary tumor lineages. After subcutaneous inoculation 2 × 106 cells, Female Swiss received 50, 100, or 150 mg/kg CAP vehicle orally once daily methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. dose-dependently reduced growth. It also viability MCF-7, MDA-MB-231, MDA-MB-436 cell Treatment with gene...
Jambo is a tropical fruit cultivated in Southeast Asia and regions of America Africa. After extraction, its polysaccharides were structurally characterized. Water soluble (WSP) composed GalA:Ara:Gal:Glc:Rha 51:22:16:5:6 molar ratio, indicating the presence pectic polysaccharides. Methylation analysis NMR spectroscopy indicated homogalacturonan (HG), type II arabinogalactan I rhamnogalacturonan (RG-I). The HG/RG-I ratio was 88%, greater amounts smooth than hairy regions. Hemicellulosic...
Inflammatory bowel disease (IBD) is a complex inflammatory disorder characterized by chronic and spontaneously relapsing inflammation of the gastrointestinal tract. IBD includes two idiopathic disorders: Crohn's (CD) ulcerative colitis (UC). In particular, UC causes ulceration colon rectum. There no cure for UC. The pharmacological treatment aimed at controlling and/or reducing process promoting remission. present study investigated possible protective effects soluble dietary fiber (SDF)...
Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity.Male Swiss mice were subjected to two protocols. first protocol (Pretreatment) consisted intraperitoneal (i.p.) treatment (0.057 0.118mgkg-1) or vehicle (distilled water) once daily for 7 days. On days 6 7, animals challenged 2% CCl4...
This study investigated the antineoplastic effects and toxicity of long-term treatment with polysaccharides from sweet green pepper (Capsicum annuum [CAP]), concomitant CAP + methotrexate (MTX) on mammary tumor cells in vivo vitro. Ehrlich were subcutaneously inoculated female Swiss mice. The (31 days) (100 mg kg−1, p.o.) reduced growth did not induce toxicity. combined protocol 100 kg−1 (p.o.) 1 MTX (i.p.) for 21 days inhibited 95%, higher than inhibition induced by alone (1.0 or 2.5 i.p.)....
Gastrointestinal toxicity, including diarrhea and inflammation, is commonly observed with the use of 5-fluorouracil (5-FU). Several studies have shown that polysaccharides are interesting bioactive macromolecules for treatment or prevention gastrointestinal diseases. Therefore, in this study, effect a polysaccharide fraction from mixture two Guavira species (Campomanesia adamantium Campomanesia pubescens), referred to here as CPW, on development intestinal mucositis was investigated....
Gastrointestinal mucositis is a serious and dose-limiting toxic side effect of oncologic treatment. Interruption cancer treatment due to gastrointestinal leads significant decrease in cure rates consequently the deterioration patient's quality life. Natural polysaccharides show variety beneficial effects, including gastroprotective effect. Treatment with soluble dietary fiber (SDF) from yellow passion fruit (Passiflora edulis) biomass residues protected gastric intestinal mucosa models...
The biological activities of plant-derived soluble dietary fibres (SDFs) have been widely investigated. Pectin from yellow passion fruit (YPF-peSDF) peels was suggested as a protective macromolecule in ulcers and colitis due to its antioxidant anti-inflammatory properties. Sepsis has high mortality morbidity is characterised by inflammatory oxidative stress imbalances. Evidence suggests that pectins may aid sepsis treatment; however, the effects YPF-peSDF on remain unclear. Herein,...
O tratamento de câncer envolve fármacos que podem causar diversos efeitos colaterais. Assim, existe uma busca por tratamentos com menor toxicidade. Dentre os compostos estudados, polissacarídeos plantas superiores destacam‑se como antioxidantes e antitumorais. objetivo deste trabalho foi avaliar antitumorais in vivo do jambo (Syzygium jambos (L.) Alston) da associação destes um padrão (metotrexato), utilizando ferramenta o tumor sólido Ehrlich em camundongos. Os grupos camundongos inoculados...