A5026962894- Probiotics and Fermented Foods
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Essential Oils and Antimicrobial Activity
- Pomegranate: compositions and health benefits
- Vibrio bacteria research studies
- Gut microbiota and health
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Oral microbiology and periodontitis research
- Antimicrobial Peptides and Activities
- Dental Health and Care Utilization
- Ion Channels and Receptors
- Dental materials and restorations
- Bee Products Chemical Analysis
- Piperaceae Chemical and Biological Studies
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
- Wound Healing and Treatments
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
Universidade Federal do Maranhão
2016-2025
Centro Universitário do Maranhão
2011-2021
Centro Científico Tecnológico - San Luis
2018
Brazilian National Association of Graduate Programs in Communication
2018
Health Center
2011
University of Arizona
2007-2008
Universidade de São Paulo
1997-2006
Instituto Butantan
1999
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen that causes hemorrhagic colitis and the hemolytic uremic syndrome. Colonization of human gut mucosa production potent Shiga toxins are critical virulence traits EHEC. Although EHEC contains numerous putative pili operons, their role in colonization natural bovine or accidental hosts remains largely unknown. We have identified an adherence factor, herein called E. common pilus (ECP), composed 21-kDa pilin subunit whose...
Abstract Background Native bees of the tribe Meliponini produce a distinct kind propolis called geopropolis. Although many pharmacological activities have already been demonstrated, little is known about geopropolis, particularly regarding its antimicrobial activity against oral pathogens. The present study aimed at investigating M. fasciculata geopropolis pathogens, effects on S. mutans biofilms, and chemical contents extracts. A gel prepared with extract was also analyzed for...
Many Clostridium species are found as commensal members of the intestinal microbiota. However, imbalances microbiota may lead to certain infections caused by these microorganisms, mainly butyricum, difficile, and perfringens. In many cases, infection recurrence can occur after antibiotics, indicating need for novel therapeutic options that act on pathogens also restore Herein, in vitro antimicrobial activity probiotic potential clinical reference strains Bifidobacterium Lactobacillus were...
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and hemolytic uremic syndrome (HUS) by colonizing the gut mucosa producing Shiga toxins (Stx). The only factor clearly demonstrated to play a role in EHEC adherence intestinal epithelial cells is intimin, which binds host cell integrins nucleolin, as well receptor (Tir) that it injects into cell. Here we report produces adhesive type IV pili, term pilus (HCP), composed of 19-kDa pilin subunit (HcpA) encoded hcpA...
More immediately, a strategy to inhibit the dysregulation of nNOS activity in skeletal muscle may be beneficial.
Since viable bacteria can persist in tooth cavities regardless of the technique used for caries removal, objective present randomized clinical trial was to examine microflora primary teeth treated by complete or partial removal carious dentin. Deciduous molars with acute lesions inner half dentin and vital pulp were randomly divided into two groups 16: which completely removed help a detector dye, from dentinoenamel junction lateral walls, while necrotic cavity floor only superficially....
Bacterial resistance to the available marketed drugs has prompted search of novel therapies; especially in regards anti-virulence strategies that aim make bacteria less pathogenic and/or decrease their probability become resistant therapy. Cinnamaldehyde is widely known for its antibacterial properties through mechanisms include interaction this compound with bacterial cell walls. However, only a handful studies have addressed effects on virulence, when tested at sub-inhibitory...
Cinnamaldehyde is a natural essential oil suggested to possess anti-bacterial and anti-inflammatory properties; activate transient receptor potential ankyrin 1 (TRPA1) channels expressed on neuronal non-neuronal cells. Here, we investigated the immunomodulatory effects of cinnamaldehyde in an vivo model systemic inflammatory response syndrome (SIRS) induced by lipopolysaccharide. Swiss mice received single oral treatment with h before LPS injection. To investigate whether are dependent TRPA1...
Escherichia coli and Staphylococcus aureus are important agents of urinary tract infections that can often evolve to severe infections. The rise antibiotic-resistant strains has driven the search for novel therapies replace use or act as adjuvants antibiotics. In this context, plant-derived compounds have been widely investigated. Cuminaldehyde is suggested major antimicrobial compound cumin seed essential oil. However, effect not fully understood. Herein, we investigated in silico vitro...
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 produces long bundles of polar type 4 pili (T4P) called HCP (for hemorrhagic pili) that form physical bridges between bacteria associating with human and animal epithelial cells. Here, we sought to further investigate whether possessed other pathogenicity attributes associated T4P production. Comparative studies performed wild-type EHEC EDL933 an isogenic hcpA mutant revealed play different roles in the biology this organism. We found...
Lactobacilli are involved in the microbial homeostasis female genital tract. Due to high prevalence of many bacterial diseases tract and resistance microorganisms various antimicrobial agents, alternative means control these infections necessary. Thus, this study aimed evaluate probiotic properties well-characterized Lactobacillus species, including L. acidophilus (ATCC 4356), brevis 367), delbrueckii ssp. 9645), fermentum 23271), paracasei 335), plantarum 8014), rhamnosus 9595), against...
Wound healing can be delayed following colonization and infection with the common bacterium Pseudomonas aeruginosa. While multiple therapies are used for their treatment, these ineffective, expensive, labour-intensive. Thus, there is an enormous unmet need treatment of infected wounds. Cinnamaldehyde, major component cinnamon oil, well known its antimicrobial properties. Herein, we investigated effects sub-inhibitory concentrations cinnamaldehyde in virulence P. We also assessed potential...
Candida yeasts are generally found in the vaginal microbiota; however, disruption of balance maintained by host factors and microorganisms results vulvovaginal candidiasis (VVC). This study evaluated antagonistic activity Lactobacillus spp. on albicans to verify whether active compounds had antifungal antivirulence activity. The antagonism assay showed that 15 out 20 strains an inhibitory effect C. albicans. Biosurfactants displayed surface-tension-reducing activity, with best value obtained...
Abstract Background Ventilator-associated pneumonia (VAP) is considered the most common nosocomial infection in intensive care unit (ICU), but its features are not fully known many hospitals Brazil. We identified clinical and epidemiological aspects associated with VAP an (ICU) a general public hospital northern Brazil performed analytical descriptive prospective cohort study. Methods analyzed data from thirty-three patients who developed while ICU. Clinical of were obtained tracheal...
Limosilactobacillus fermentum (ATCC 23271) was originally isolated from the human intestine and has displayed antimicrobial activity, primarily against Candida species. Complete genome sequencing comparative analyses were performed to elucidate genetic basis underlying its probiotic potential. The ATCC 23271 found contain 2,193,335 bp, with 2123 protein-coding sequences. Phylogenetic analysis revealed that strain shares 941 gene clusters six other strains of L. fermentum. Putative genes...
Chikungunya virus (CHIKV), the causative agent of chikungunya fever, is an alphavirus widely transmitted by bite female mosquito genus Aedes sp., especially in tropical and subtropical regions. Brazil country most affected microorganism. CHIKV classically induces articular pain, which can become long lasting for even years a great number infected individuals, reducing their quality life. The mechanisms CHIKV-induced pain are poorly understood, but recent evidence indicated role transient...
The relationship between clinical characteristics of carious dentin and bacterial colonization after partial caries removal is not completely understood. aim this study was to compare microbial counts categories color, consistency humidity, evaluate the correlation these presence cariogenic microorganisms in deep cavities (2/3 or more thickness) submitted removal. Sixteen primary teeth were all tissue from lateral walls cavity, whereas pulp wall removed superficially. Dentin classified...
Bacteria that produce Klebsiella pneumoniae carbapenemases (KPCs) are resistant to broad-spectrum β-lactam antibiotics. The objective of this study was phenotypically and genotypically characterize the antibiotic susceptibility carbapenems 297 isolates recovered from clinical samples obtained inpatients at 16 hospitals in São Luis (Maranhão, Brazil). conducted using phenotypic tests molecular methods, including polymerase chain reaction (PCR), sequencing enterobacterial repetitive intergenic...
The objective of this study was to evaluate the antibacterial action filamentous bacteria isolated from Byrsonima crassifolia leaf. An endophytic bacterium classically and molecularly identified as Streptomyces anschromogenes. Screening for against pathogens with medical relevance (Klebsiella pneumoniae ATCC 0023, P. aeruginosa 0030, Staphylococcus aureus 6538, Corynebacterium diphteriae 27012, Mycobacterium abscessus massilienseGo01, Cryptococcus gattii 24065, neofarmans 24067) demonstrated...
Pseudomonas aeruginosa has caused high rates of mortality due to the appearance strains with multidrug resistance (MDR) profiles. This study aimed characterize molecular profile virulence and genes in 99 isolates P. recovered from different clinical specimens. The were identified by automated method Vitek2, antibiotic susceptibility was determined using classes antimicrobials. genomic DNA extracted amplified multiplex polymerase chain reaction (mPCR) detect antimicrobial genes. Molecular...
Patients with rheumatoid arthritis (RA) suffer from pain and joint disability. The transient receptor potential ankyrin 1 (TRPA1) channel expressed on sensory neurones non-neuronal cells mediates transduction inflammation it has been implicated in RA. However, there is little information the contribution of TRPA1 for human disease. Here, we investigated expression peripheral blood leukocytes circulating levels its endogenous activators 4-hydroxynonenal (4-HNE) hydrogen peroxide (H2O2) RA...
<b><i>Aim:</i></b> This study evaluated the acidogenicity of human milk by dental biofilms children with and without early childhood caries (ECC). <b><i>Method:</i></b> Biofilms 16 (7 ECC; 9 free) were exposed to or 10% sucrose solution in crossover design, biofilm pH was determined. <b><i>Results:</i></b> Breastfeeding did not provoke a decrease pH, irrespective children's status, whereas decreased for both groups. In...