A5010741371- Polysaccharides and Plant Cell Walls
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Fungal Biology and Applications
- Seaweed-derived Bioactive Compounds
- Pain Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- COVID-19 and healthcare impacts
- Aortic aneurysm repair treatments
- COVID-19 Clinical Research Studies
- Environmental Toxicology and Ecotoxicology
- Exercise and Physiological Responses
- Phytochemistry Medicinal Plant Applications
- Vascular Procedures and Complications
- Muscle Physiology and Disorders
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
- Metal complexes synthesis and properties
- Glutathione Transferases and Polymorphisms
- Phytochemicals and Antioxidant Activities
- Calpain Protease Function and Regulation
- Traditional Chinese Medicine Analysis
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and biological activity of medicinal plants
- Bioactive Natural Diterpenoids Research
Universidade Federal do Paraná
2014-2024
University of Coimbra
2022
Instituto de Pesca
2021-2022
Instituto de Tecnologia do Paraná
2020-2021
Fundación Universitaria Sanitas
2020
Universidad de La Sabana
2013-2015
Emory University
2011-2012
Introduction: The Facultad de Medicina of the Universidad La Sabana routinely uses lectures as major educational strategy in clinical areas. Since 2012, a curriculum context and flipped classroom were introduced surgery course.Objective: To compare impact versus model learning environment surgery.Materials methods: Dundee Ready Education Environment Measure (DREEM) questionnaire was administered to four cohorts students. five domains overall scores for both strategies analyzed, ANOVA used...
The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in Ehrlich carcinoma mice and human mammary tumor lineages. After subcutaneous inoculation 2 × 106 cells, Female Swiss received 50, 100, or 150 mg/kg CAP vehicle orally once daily methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. dose-dependently reduced growth. It also viability MCF-7, MDA-MB-231, MDA-MB-436 cell Treatment with gene...
Rhamnogalacturonan (RGal) is a polysaccharide isolated from Acmella oleracea that ameliorates the intestinal barrier in an ulcerative colitis model induced by dextran sulfate sodium (DSS) and Caco-2 cells. Here we investigate if RGal could reduce visceral pain, inflammation, oxidative stress gastrointestinal dysmotility. Acetic acid, capsaicin or mustard oil were used to assess pain normal mice. Ulcerative was with DSS (10 mg/kg) given orally for 7 days. reduced abdominal contortions, cell...
Increases in protein kinase C (PKC) and oxidative stress have been related to mania. Drugs with antioxidant effects or inhibitory actions on PKC may antimanic effects. The flavonoid quercetin has PKC-inhibiting that resemble those of lithium, the first-line treatment for mania bipolar disorder. We hypothesized antimanic-like an animal model.In present study, we investigated acute chronic (2.5, 5, 10, 40mg/kg, i.p.) male Swiss mice were subjected methylphenidate (5mg/kg, i.p.)-induced...
Polysaccharides are substances that modify the biological response to several stressors. The present study investigated antitumor activity of soluble fraction polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. monosaccharide composition had a complex mixture, suggesting presence arabinoglactans, mannans, and pectins. Treatment with SFP (30 60 mg/kg, oral) for 14 days significantly reduced tumor weight volume compared controls. mg/kg blood...
The present study evaluated the effects of acute treatment with silymarin, an extract that is obtained from Silybum marianum, on angiogenesis, oxidative stress, and inflammation in normoglycemic diabetic mice. Diabetes was induced by streptozotocin (80 mg/kg, intraperitoneal) male Swiss mice, 6 weeks age. A polyether-polyurethane sponge surgically implanted back mice as a model healing both animals were treated oral silymarin or water for 10 days. pancreas, liver, kidneys, blood, sponges...
Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity.Male Swiss mice were subjected to two protocols. first protocol (Pretreatment) consisted intraperitoneal (i.p.) treatment (0.057 0.118mgkg-1) or vehicle (distilled water) once daily for 7 days. On days 6 7, animals challenged 2% CCl4...
The present study evaluated the in vivo antitumor effects and toxicity of a new Ru(II) compound, cis-(Ru[phen]2[ImH]2)2+ (also called RuphenImH [RuC]), against Walker-256 carcinosarcoma rats. After subcutaneous inoculation cells right pelvic limb, male Wistar rats received 5 or 10mgkg-1 RuC orally intraperitoneally (i.p.) every 3 days for 13 days. A positive control group (2mgkg-1 cisplatin) negative (vehicle) were also used. Tumor progression was checked daily. treatment, tumor weight,...
In December 2019, a new coronavirus called SARS-CoV-2 emerged from zoonotic source in Wuhan, China. One of its main characteristics is easy propagation through airborne droplets symptomatic and asymptomatic patients. thus has spread quickly, infecting 2 million people more than 200 countries. It the first to be considered pandemic. Its mortality rate ranges 1% 10%.1World Health OrganizationCoronavirus disease (COVID-2019) Situation Report 84. WHO, Geneva, Switzerland2020Google Scholar,2World...
This study investigated the antineoplastic effects and toxicity of long-term treatment with polysaccharides from sweet green pepper (Capsicum annuum [CAP]), concomitant CAP + methotrexate (MTX) on mammary tumor cells in vivo vitro. Ehrlich were subcutaneously inoculated female Swiss mice. The (31 days) (100 mg kg−1, p.o.) reduced growth did not induce toxicity. combined protocol 100 kg−1 (p.o.) 1 MTX (i.p.) for 21 days inhibited 95%, higher than inhibition induced by alone (1.0 or 2.5 i.p.)....