A5073083889- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Mitochondrial Function and Pathology
- Drug Transport and Resistance Mechanisms
- Vanadium and Halogenation Chemistry
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Biological Activities
- Metal complexes synthesis and properties
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- DNA and Nucleic Acid Chemistry
- Seaweed-derived Bioactive Compounds
- Redox biology and oxidative stress
- Synthesis and Biological Evaluation
- ATP Synthase and ATPases Research
- Research on Leishmaniasis Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Free Radicals and Antioxidants
- Metabolomics and Mass Spectrometry Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cynara cardunculus studies
- Vitamin C and Antioxidants Research
Universidade Federal do Paraná
2016-2025
Instituto de Biologia Molecular do Paraná
2017
Centro Universitário Curitiba
2015
A series of indeno[1,2-b]indole-9,10-dione derivatives were synthesized as human casein kinase II (CK2) inhibitors. The most potent inhibitors contained a N5-isopropyl substituent on the C-ring. same compounds was found to also inhibit breast cancer resistance protein ABCG2 but with totally different structure–activity relationships: N5-phenethyl critical, and additional hydrophobic substituents at position 7 or 8 D-ring methoxy phenethyl ortho meta contributed inhibition. best inhibitors,...
Apigenin has been reported to inhibit proliferation of cancer cells; however, the mechanism underlying its action is not completely understood. Here, we evaluated effects apigenin on levels expression and activity antioxidant enzymes, involvement ROS in cell death induced by HepG2 human hepatoma cells. Upon treatment with apigenin, cells displayed a reduction viability dose- time-dependent manner, some morphological changes. In addition, generation significantly decreased mRNA catalase...
The aim of this study was to determine whether endemic Antarctic nototheniid fish are able adjust their liver antioxidant defence system in response the temperature increase. activity superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and reductase (GR) enzymes as well content non-enzymatic oxidative stress markers such reduced (GSH), lipid peroxidation (LPO) protein carbonyl (PC) were measured two species, Notothenia rossii coriiceps...
The understanding of metabolism during cell proliferation and commitment provides a greater insight into the basic biology cells, allowing future applications. Here we evaluated energy oxidative changes early adipogenic differentiation human adipose tissue-derived stromal cells (hASCs). hASCs were maintained under conditions 3 7 days. Oxygen consumption, mitochondrial mass membrane potential, reactive oxygen species (ROS) generation, superoxide dismutase (SOD) catalase activities,...
Hepatocellular carcinoma (HCC) is a common and deadly form of liver cancer with limited treatment options for advanced stages. Mesoionic compounds MI-D MI-J have shown potential treating HCC due to their significant toxicity these cells. This study investigated whether this linked effects on oxidative balance in HepG2 cells cultured high glucose (HG-glycolysis-dependent) galactose plus glutamine supplemented (GAL- phosphorylation-dependent) DMEM medium. ROS levels were increased both media...
The cytotoxic activity of β-D-glucans isolated from Agaricus bisporus and Lactarius rufus fruiting bodies was evaluated on human hepatocellular carcinoma cells (HepG2). NMR methylation analysis suggest that these β-d-glucans were composed a linear (1→6)-linked branched (1→3), backbone, respectively. They both decreased cell viability at concentrations up to 100 μg mL(-1), as shown by MTT assay. amount LDH released the morphology corroborated values also showed β-D-glucan L. more HepG2 than...
Keywords: multidrug resistance, cancer cells, ABCG2/BCRP, indenoindole inhibitors, structure–activity relationships, ATPase activity
Abstract: A series of chalcones substituted by a quinoxaline unit at the B-ring were synthesized and tested as inhibitors breast cancer resistance protein-mediated mitoxantrone efflux. These compounds appeared more efficient than analogs containing other substituents such 2-naphthyl or 3,4-methylenedioxyphenyl while an intermediate inhibitory activity was obtained with 1-naphthyl group. In all cases, two three methoxy groups had to be present on phenyl A-ring produce maximal inhibition....
Hispidulin (6-methoxy-5,7,4′-trihydroxyflavone) and eupafolin (6-methoxy-5,7,3′,4′-tetrahydroxyflavone), are flavonoids found in the leaves of Eupatorium litoralle. They have recognized antioxidant antineoplastic properties, although their action mechanisms not been previously described. We now report effects hispidulin on oxidative metabolism isolated rat liver mitochondria (Mit) also investigated prooxidant capacity both flavonoids. (0.05–0.2 mM) decreased respiratory rate state III...
The present study evaluated the effects of acute treatment with silymarin, an extract that is obtained from Silybum marianum, on angiogenesis, oxidative stress, and inflammation in normoglycemic diabetic mice. Diabetes was induced by streptozotocin (80 mg/kg, intraperitoneal) male Swiss mice, 6 weeks age. A polyether-polyurethane sponge surgically implanted back mice as a model healing both animals were treated oral silymarin or water for 10 days. pancreas, liver, kidneys, blood, sponges...
Abstract Cyclic imides such as succinimides, maleimides, glutarimides, phthalimides and their derivatives contain an imide ring a general structure -CO-N(R)-CO- that confers hydrophobicity neutral characteristic. A diversity of biological activities pharmaceutical uses have been attributed to them, antibacterial, antifungal, antinociceptive, anticonvulsant, antitumor. In spite these activities, much action mechanisms at molecular cellular levels remain be elucidated. We now show the effects...
Abstract In neoplasic cachexia, chemical mediators seem to act as initiators or perpetuators of this process. Walker 256 cells, whose metabolic properties have so far been little studied with respect cancer are used a model for the study syndrome. The main objective research was pinpoint substances secreted by these cells that may contribute progression cachectic state. Since inflammatory be involved in manifestation syndrome, vitro production nitric oxide (NO), cytokines (tumor necrosis...
The present study evaluated the in vivo antitumor effects and toxicity of a new Ru(II) compound, cis-(Ru[phen]2[ImH]2)2+ (also called RuphenImH [RuC]), against Walker-256 carcinosarcoma rats. After subcutaneous inoculation cells right pelvic limb, male Wistar rats received 5 or 10mgkg-1 RuC orally intraperitoneally (i.p.) every 3 days for 13 days. A positive control group (2mgkg-1 cisplatin) negative (vehicle) were also used. Tumor progression was checked daily. treatment, tumor weight,...