A5031679068- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Biochemical and Molecular Research
- Nanoparticle-Based Drug Delivery
- Iron oxide chemistry and applications
- Characterization and Applications of Magnetic Nanoparticles
- Quinazolinone synthesis and applications
- RNA and protein synthesis mechanisms
- Carbohydrate Chemistry and Synthesis
- Pharmacological Effects of Natural Compounds
- Biochemical and Structural Characterization
- Research on Leishmaniasis Studies
- Tuberculosis Research and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Soil Science and Environmental Management
- Synthesis of β-Lactam Compounds
- Water Resource Management and Quality
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Hibiscus Plant Research Studies
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Electrospun Nanofibers in Biomedical Applications
- Phytochemistry and biological activity of medicinal plants
Universidad Católica de Cuenca
2021-2023
University of Cuenca
2021-2022
Universidade Federal do Paraná
2016-2019
Tuberculosis is a disease that remains significant threat to public health worldwide, and this mainly due the selection of strains increasingly resistant Mycobacterium tuberculosis, its causative agent. One validated targets for development new antibiotics DNA gyrase. This enzyme type II topoisomerase responsible regulating topology and, as it essential in bacteria. Thus, contribute search molecules with potential act competitive inhibitors at active site M. tuberculosis gyrase B, present...
The World Health Organization reported that tuberculosis remains on the list of top ten threats to public health worldwide. Among main causes is limited effectiveness treatments due emergence resistant strains Mycobacterium tuberculosis. One drug targets studied combat M. DNA gyrase, only enzyme responsible for regulating topology in this specie and considered essential all bacteria. In context, present work tested ability 2824 anthraquinones retrieved from PubChem database act as...
Increasing rates of bacterial resistance to antibiotics are a growing concern worldwide. The search for potential new has included several natural products such as anthraquinones. However, comparatively less attention been given anthraquinones that exhibit functional groups uncommon in nature. In this work, 114 were evaluated using silico methods identify inhibitors the enzyme phosphopantetheine adenylyltransferase (PPAT) Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli....
Abstract The World Health Organization reported that tuberculosis remains on the list of top ten threats to public health worldwide. Among main causes is limited effectiveness treatments due emergence a diverse spectrum resistant strains Mycobacterium , causative agent disease. One drug targets studied combat M. DNA gyrase, only enzyme responsible for regulating topology in this specie and considered essential all bacteria. In context, present work tested ability 2,824 anthraquinones...
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The spread of nosocomial infections caused by antibiotic-resistant Enterococcus faecalis is one the major threats to global health at present. While aminoglycosides are often used combat these infections, their effectiveness reduced various resistance mechanisms, including aminoglycoside modifying enzymes, and there currently no drugs inhibit enzymes. To address this issue, study was conducted identify potential adjuvants from a database 462 flavones. affinity molecules with...
Nosocomial infections remain a constant threat worldwide mainly due to antibiotic resistance of species such as Enterococcus faecalis . Among the main classes antibiotics used against this bacterium are aminoglycosides, but many mechanisms compromise their effectiveness. The action aminoglycoside modifying enzymes represents one most studied mechanisms, because it is representative in enterococci. Based on problem, work 462 flavones from ChemSpace database small molecules find potential...
Enterococcus faecalis is a bacterium that can develop multidrug resistance profile associated with the community as well nosocomial-acquired infections. Among treatment options for these infections are aminoglycosides combined bacterial cell wall inhibitors such beta-lactams, since E. intrinsically resistant to aminoglycosides. One of its most representative mechanisms expression aminoglycoside-modifying enzymes, aminoglycoside phosphotransferase type IIIa (EfAPH(3')-IIIa). This enzyme acts...