A5072437452- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Advanced MRI Techniques and Applications
- Synthesis and Biological Evaluation
- Advanced NMR Techniques and Applications
- Carbon dioxide utilization in catalysis
- Synthesis and Reactivity of Heterocycles
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Atomic and Subatomic Physics Research
- Fermentation and Sensory Analysis
- Ionic liquids properties and applications
- Dendrimers and Hyperbranched Polymers
- Synthesis and Characterization of Heterocyclic Compounds
- Ferrocene Chemistry and Applications
- CO2 Reduction Techniques and Catalysts
- RNA Research and Splicing
- Catalytic Cross-Coupling Reactions
- Marine Sponges and Natural Products
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Inhalation and Respiratory Drug Delivery
Université de Bordeaux
2015-2025
Institut des Sciences Moléculaires
2016-2025
Centre National de la Recherche Scientifique
2015-2025
Institut Polytechnique de Bordeaux
2008-2025
Institut de Biochimie et Génétique Cellulaires
2020
John Radcliffe Hospital
2020
Wellcome Centre for Integrative Neuroimaging
2020
Université de Pau et des Pays de l'Adour
2013
Inserm
2007-2011
Institut National Polytechnique de Toulouse
2008
Upon catalyst and substrate encapsulation, an amphiphilic dendrimer containing 27 triethylene glycol termini 9 intradendritic triazole rings serves as a catalytic nanoreactor by considerably accelerating the Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) "click" reactions of various substrates in water using Cu(hexabenzyltren)Br (tren = triaminoethylamine). Moreover this recyclable with strongly also activates simple Sharpless-Fokin CuSO4 + sodium ascorbate under ambient conditions...
Diamond-Blackfan anemia (DBA) is a rare congenital disease affecting erythroid precursor differentiation. DBA emerging as paradigm for new class of pathologies potentially linked to disorders in ribosome biogenesis. Three genes encoding ribosomal proteins have been associated DBA: after RPS19, mutations RPS24 and RPS17 were recently identified fraction the patients. Here, we show that cells from patients carrying defective pre-rRNA maturation, case RPS19 mutations. However, contrast...
In organoleptic science, the association of tannins to saliva proteins leads poorly understood phenomenon astringency. To decipher this interaction at molecular and colloidal levels, binding 4 procyanidin dimers (B1–4) 1 trimer (C2) a human proline-rich peptide, IB714, was studied. Interactions have been characterized by measuring dissociation constants, sizes complexes, number, nature sites using NMR (chemical shift variations, diffusion-ordered spectroscopy, saturation transfer diffusion)....
The solvation of CO(2) in 1-butyl-3-methylimidazolium acetate (Bmim Ac) has been investigated by (1)H, (13)C, and (15)N NMR spectroscopy at low molar fraction (mf) (x(CO(2)) ca. 0.27) corresponding to the reactive regime described part 1 this study. It is shown that a carboxylation reaction occurs between Bmim Ac, leading formation non-negligible amount (~16%) 1-butyl-3-methylimidazolium-2-carboxylate. also found acetic acid molecules are produced during tend form with elapsed time stable...
The formation of 1-butyl-3-methylimidazolium-2-carboxylate in the mixture CO(2) with 1-butyl-3-methylimidazolium acetate under mild conditions (298 K, 0.1 MPa) has been put evidence liquid phase using Raman and infrared spectroscopy complemented by DFT calculations NMR ((1)H, (13)C, (15)N) spectroscopy.
A series of indeno[1,2-b]indole-9,10-dione derivatives were synthesized as human casein kinase II (CK2) inhibitors. The most potent inhibitors contained a N5-isopropyl substituent on the C-ring. same compounds was found to also inhibit breast cancer resistance protein ABCG2 but with totally different structure–activity relationships: N5-phenethyl critical, and additional hydrophobic substituents at position 7 or 8 D-ring methoxy phenethyl ortho meta contributed inhibition. best inhibitors,...
Diamond-Blackfan anemia (DBA) is a rare congenital disease linked to mutations in the ribosomal protein genes rps19, rps24 and rps17. It belongs emerging class of disorders. To understand impact DBA on RPS19 function, we have solved crystal structure from Pyrococcus abyssi. The forms five alpha-helix bundle organized around central amphipathic alpha-helix, which corresponds mutation hot spot. From structure, classify relative their respective folding (class I) or surface properties II)....
In HIV-1, trans-activation of transcription the viral genome is regulated by an imperfect hairpin, trans-activating responsive (TAR) RNA element, located at 5′ untranslated end all transcripts. TAR acts as a binding site for and cellular proteins. attempt to identify ligands that would interfere with virus life-cycle interacting TAR, in vitro selection was previously carried out. hairpins formed kissing-loop dimers were selected [Ducongé F. Toulmé JJ (1999) RNA, 5:1605–1614]. We describe...
The mechanism of the ring-opening polymerization (ROP) lactide catalyzed by two partner hydrogen-bonding organocatalysts was explored. New amidoindoles 4 a,c, thioamidoindoles b,d, amidobenzimidazoles 5 and thioamidobenzimidazoles b,c were synthesized used as activators monomer. In solid state in solution, compounds showed a propensity for self-association, which evaluated. (Thio)Amides do catalyze ROP presence cocatalyst, tertiary amine 3 or b, activates growing polymer chain through...
The colloidal behavior of eight synthetic procyanidins (three monomers, four dimers, and a trimer) has been investigated in water or winelike medium using DOSY NMR spectroscopy molecular dynamics simulations. Different was observed for monomers oligomers. Monomers self-associate with high affinity constant (37−53 M−1) to form micelles at low cmc (critical micelle concentration) values (1−5 g·L−1). These undergo time-dependent coalescence process hazes precipitates. As dimers the trimer,...
Abstract Encapsulation of docetaxel and its solubilization in water was carried out PEGylated gold nanoparticles (AuNPs) as shown by 1 H NMR (600 MHz ) UV/Vis spectroscopy dynamic light scattering. Vectorization AuNP‐encapsulated probed vitro toward human colon carcinoma (HCT15) breast cancer (MCF7) cells. AuNPs alone presented no cytotoxicity either MCF7 or HCT15 adenocarcinoma AuNP–docetaxel found to be 2.5‐fold more efficient than against cells, the IC 50 value cells lower that free...
The controlled synthesis of monodisperse, redox-active metallopolymers and their redox properties functions, including robust electrode derivatization sensing, remains a challenge. Here series polynorbornene homopolymers block copolymers containing side-chain amidoferrocenyl groups tetraethylene glycol linkers were prepared via living ring-opening metathesis polymerization initiated by Grubbs' third-generation catalyst (1). Their molecular weights determined using MALDI-TOF mass spectra,...
Abstract Acute leukemia is a hematological malignancy with high incidence and recurrence rates characterized by an accumulation of blasts in bone marrow due to proliferation immature lymphoid or myeloid cells associated blockade differentiation. The heterogeneity led us look for new specific molecules subtypes therapy‐resistant cases. Among heterocyclic derivatives that attracted attention their wide range biological activities, we focused our interest on the pyrrolo[1,2‐ ]quinoxaline...
Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design ATP-competitive inhibitors human CK2. In present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all which were tested in vitro on The indenoindolones 5a and 5b inhibited CK2 with an IC50 0.17 0.61 µM, respectively. indeno[1,2-b]indoloquinone 7a also showed inhibitory activity at a submicromolar range (IC50 = 0.43 µM). Additionally, large number indenoindole...
The administration of exogenous surfactant is essential for many premature infants to compensate pulmonary immaturity and the absence endogenous at birth. Exogenous delivery techniques are continually being refined improve management these infants, with goal increasing therapeutic efficacy decreasing invasiveness protocols. Imaging one tools available achieve goals. In this study, we established applied an magnetic resonance imaging (MRI) protocol in a rabbit animal model determine...
The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at 3' ends mRNAs. This heterotrimeric complex built around 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved crystal structure from Encephalitozoon cuniculi a resolution 2 Å. folds 11 Half-a-TPR repeats defining two domains. reveals tight homodimer exposing phylogenetically conserved areas interaction with partners. Mapping experiments identify C-terminal region Rna14p,...
The derivatization of macromolecules with redox-stable groups is a challenge for molecular electronics applications. large majority redox-derivatized involve ferrocenes, and there are only few reports cobalticinium. We report here the first click cobalticinium redox group using ethynylcobalticinium hexafluorophosphate, 1. CuI catalysis was used these selective metallodendrimer syntheses starting from 1 providing tripodal dendron 3 that contains three 1,2,3-triazolylcobalticinium termini...