A5020817130- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Neuropeptides and Animal Physiology
- Phytochemicals and Antioxidant Activities
- Polysaccharides and Plant Cell Walls
- Dysphagia Assessment and Management
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- NF-κB Signaling Pathways
- Receptor Mechanisms and Signaling
- Microbial Metabolites in Food Biotechnology
- Vagus Nerve Stimulation Research
Universidade Federal do Ceará
2020-2025
This study aimed to evaluate the role of pepsin inhibitors in inflammatory response and their effects on laryngeal mucosal integrity during gastroesophageal reflux (GERD) under vivo conditions.
Inflammatory bowel disease can be triggered by disturbances in intestinal mucosal integrity, leading to bacterial transmigration. The treatment of inflammatory diseases must not only aim reduce inflammation, but also reverse the damage barrier function. Janus kinase (JAK) inhibitors have been used treat diseases, including ulcerative colitis. However, little is known about ability this class drugs loss integrity. This study evaluated effects tofacitinib, a JAK pathway inhibitor, on...
Objective This study aimed to evaluate the in vivo protective effect of angico gum biopolymer reducing inflammatory response and preserving integrity laryngeal esophageal mucosa. Study Design Animal study. Methods A murine surgical model gastroesophageal reflux disease was accomplished subsequently treated with or omeprazole. On days 3 7 post surgery, samples larynx esophagus, respectively, were collected measure level inflammation (wet weight myeloperoxidase activity) mucosal...