A5023728653- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Microscopic Colitis
- Inflammatory mediators and NSAID effects
- Thyroid Disorders and Treatments
- Barrier Structure and Function Studies
- Pulsars and Gravitational Waves Research
- Eicosanoids and Hypertension Pharmacology
- Hemostasis and retained surgical items
- Ion Channels and Receptors
- Veterinary medicine and infectious diseases
- Seaweed-derived Bioactive Compounds
- Neutropenia and Cancer Infections
- Cynara cardunculus studies
- Inflammatory Bowel Disease
- Advances in Cucurbitaceae Research
- Quantum, superfluid, helium dynamics
- High-Energy Particle Collisions Research
- Renin-Angiotensin System Studies
- Microbial Metabolites in Food Biotechnology
- Nutrition, Genetics, and Disease
- Receptor Mechanisms and Signaling
Universidade Federal do Ceará
2018-2025
This study aimed to evaluate the role of pepsin inhibitors in inflammatory response and their effects on laryngeal mucosal integrity during gastroesophageal reflux (GERD) under vivo conditions.
Inflammatory bowel disease can be triggered by disturbances in intestinal mucosal integrity, leading to bacterial transmigration. The treatment of inflammatory diseases must not only aim reduce inflammation, but also reverse the damage barrier function. Janus kinase (JAK) inhibitors have been used treat diseases, including ulcerative colitis. However, little is known about ability this class drugs loss integrity. This study evaluated effects tofacitinib, a JAK pathway inhibitor, on...
Microscopic inflammation and impairment of the esophageal epithelial barrier are considered relevant for perception symptoms in patients with nonerosive reflux disease (NERD). In these patients, receptor transient potential vanilloid 1 (TRPV1) is overexpressed mucosa, but its role not yet fully understood. We evaluated TRPV1 mucosal a murine model NERD.
Objectives/Hypothesis The objectives of this study were to evaluate laryngeal inflammation and mucosal integrity in a murine model reflux disease assess the protective effects topical agents including alginate, hyaluronic acid, cashew gum. Study Design Animal study. Methods A surgical was evaluated at 3 or 7 days postsurgery, samples collected measure (wet weight myeloperoxidase [MPO]) (transepithelial resistance [TER] permeability fluorescein). Additional groups animals administered one...
Objective This study aimed to evaluate the in vivo protective effect of angico gum biopolymer reducing inflammatory response and preserving integrity laryngeal esophageal mucosa. Study Design Animal study. Methods A murine surgical model gastroesophageal reflux disease was accomplished subsequently treated with or omeprazole. On days 3 7 post surgery, samples larynx esophagus, respectively, were collected measure level inflammation (wet weight myeloperoxidase activity) mucosal...
Angico gum (AG) (Anadenanthera colubrina var. Cebil [Griseb.] Altschul) is utilized by some Brazilian communities to alleviate symptoms from gastroesophageal reflux disease. Here, we aimed investigate the "in vitro" topical protective capacity of AG on human esophageal mucosa.
The role of cyclooxygenase (COXs) isoforms in maintaining colonic mucosal integrity is not fully understood. This study aimed to evaluate the COX-1 and -2 on an experimental colitis model. Colitis was induced Wistar rats by intracolonic administration 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). control group (sham group) received saline only. After 7, 14, or 28 days, samples were removed, macroscopic lesion scores, wet weight, myeloperoxidase activity, transepithelial...
In this article, we explore the cooling of isolated quark stars. These objects are structured a homogeneous matter core and crusted by matter. To do this, adopt two kinds crust: (i) crust made purely nuclear following Baym-Pethick-Sutherland (BPS) equation state (EoS) (ii) nuggets strange (strangelets). Both models have same described MIT bag model EoS. Our main purpose is to quantify effects strangelet on relaxation times these We also perform thorough study thermal stars, in which found...