A5091701598- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Treatments and Mutations
- Cardiac tumors and thrombi
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Coronary Interventions and Diagnostics
- Kawasaki Disease and Coronary Complications
- Vasculitis and related conditions
- Coronary Artery Anomalies
- Sarcoma Diagnosis and Treatment
- Trypanosoma species research and implications
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Viral-associated cancers and disorders
- Sarcoidosis and Beryllium Toxicity Research
- Histiocytic Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Vascular Tumors and Angiosarcomas
- Cardiac Structural Anomalies and Repair
Universidade Federal do Ceará
2004-2025
Hospital de Messejana
2013-2024
Juntendo University
2024
Sociedade Brasileira de Cardiologia
2023
Brown University
2020
Lifespan
2020
Unichristus
2019-2020
Hospital Geral de Fortaleza
2016
University of Maryland, Baltimore
2005-2014
Armed Forces Institute of Pathology
2007-2010
Abstract Background Chikungunya virus (CHIKV) emerged in the Americas 2013 and has caused approximately 2.1 million cases >600 deaths. A retrospective investigation was undertaken to describe clinical, epidemiological, viral genomic features associated with deaths by CHIKV Ceará state, northeast Brazil. Methods Sera, cerebrospinal fluid (CSF), tissue samples from 100 fatal suspected arbovirus infection were tested for CHIKV, dengue (DENV), Zika (ZIKV). Clinical, death reports obtained...
Myeloperoxidase (MPO) -containing macrophages and neutrophils have been described at sites of plaque rupture. The presence these cells in precursor lesions to acute rupture (thin cap atheroma, or vulnerable plaque) within thrombi adjacent ruptures has not described, nor an association with iron-containing unstable plaques.We studied 61 ruptures, 15 organizing 31 thin fibroatheromas, 28 fibroatheromas from 72 sudden coronary death victims by immunohistochemical histochemical techniques....
Introduction: The International Association for the Study of Lung Cancer (IASLC) recently reclassified adenocarcinomas lung on basis histologic patterns. However, there is lack consensus about a grading system these tumors. We studied series invasive and correlated features with lymph node distant metastases. A carcinomas resected over 5-year period were retrospectively reviewed classified by IASLC system. proportion each subtype was estimated at 5% increments, cytologic blindly recorded...
Chagas disease (CD) affects approximately 6–7 million people worldwide, from which 30% develop chronic cardiomyopathy (CCC), usually after being asymptomatic for years. Currently available diagnostic methods are capable of adequately identifying infected patients, but do not provide information regarding the individual risk developing most severe form disease. The identification biomarkers that predict progression or indeterminate to CCC, may guide early implementation pharmacological...
Abstract Aberrant activation of the androgen receptor (AR) by ErbB2/ErbB3 heterodimer contributes to development hormone resistance in prostate cancer. EBP1, an ErbB3-binding protein, acts as AR corepressor. As EBP1 is decreased preclinical models hormone-refractory cancer, we studied expression human We found that gene was significantly cancer tissues compared with benign at both mRNA and protein levels. Restoration LNCaP C81 cell line led amelioration androgen-independent phenotype based...
Primary sarcomas of the pulmonary artery are rare, with few series correlating histologic features follow-up data. We present a 43 primary intraluminal growth, 32 information. Symptoms were generally related to shortness breath and often attributed recurrent embolism. There was no sex predilection. 28 pleomorphic-fascicular sarcomas, ranging from relatively differentiated spindle cell myxofibrosarcoma undifferentiated round-cell sarcoma, heterogeneity overlap. The remaining tumors 7...
Abstract Classification of renal cell carcinomas has become more challenging. The 2016 WHO classification included 14 different subtypes and 4 emerging/provisional entities, recent literature indicates new entities to be incorporated. Nomenclature is based on cytoplasmic appearance, architecture, combination morphologies, anatomic location, underlying disease, familial syndromes, specific genetic alterations. Immunohistochemistry useful in selected cases while it can insufficient that...
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasocentric process characterized by infiltrates of lymphocytes and eosinophils, usually affecting the muscular arteries head neck. Currently it unclear whether reactive or neoplastic process.We present 61-year-old African American male twenty year history superficial skin patches involving neck region. An excisional biopsy right submental lymph node revealed an atypical T-cell lymphocytic process, diagnosed as peripheral lymphoma after...
Glucose transporter-1 (GLUT-1) mediates the transport of glucose across cellular membrane. Its elevated levels and/or activation have been shown to be associated with malignancy. The aim this study was investigate GLUT-1 expression in pulmonary neuroendocrine carcinomas. Tissue microarray-based samples 178 carcinomas, including 48 typical carcinoids, 31 atypical 27 large cell carcinomas and 72 small from different patients, were studied immunohistochemically for expression. Forty-seven...