A5022369420- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cutaneous lymphoproliferative disorders research
- Multiple Myeloma Research and Treatments
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Hematological disorders and diagnostics
- Tumors and Oncological Cases
- Parvovirus B19 Infection Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Chronic Myeloid Leukemia Treatments
- Cardiac tumors and thrombi
- IgG4-Related and Inflammatory Diseases
- Medical Imaging and Pathology Studies
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- Antioxidant Activity and Oxidative Stress
- Retinoids in leukemia and cellular processes
University of Virginia Health System
2015-2025
University of Virginia
2013-2024
University of Virginia Hospital
2024
Erciyes University
2020
Saint Barnabas Medical Center
2020
Beaumont Hospital, Royal Oak
2012-2020
Mount Sinai Medical Center
2020
Walter Reed National Military Medical Center
2019
NeoGenomics (United States)
2019
University of Iowa Hospitals and Clinics
2019
Histiocytic sarcoma is a rare malignant neoplasm that may occur de novo or in the context of previous hematologic malignancy mediastinal germ cell tumor. Here, we performed whole exome sequencing and RNA-sequencing (RNA-Seq) on 21 archival cases primary histiocytic sarcoma. We identified high number genetic alterations within RAS/RAF/MAPK pathway cases, with NF1 (6 21), MAP2K1 (5 PTPN11 (4 BRAF KRAS NRAS (1 LZTR1 including single homozygous deletion NF1, high-level amplification PTPN11,...
Chronic inflammation is frequently associated with myeloproliferative neoplasms (MPN), but the role of in pathogenesis MPN remains unclear. Expression proinflammatory cytokine interleukin-1 (IL-1) elevated patients as well Jak2V617F knock-in mice. Here, we show that genetic deletion IL-1 receptor 1 (IL-1R1) normalizes peripheral blood counts, reduces splenomegaly and ameliorates bone marrow fibrosis homozygous mouse model myelofibrosis. Deletion IL-1R1 also significantly mutant hematopoietic...
Abstract Context.—Inflammatory pseudotumor is an uncommon and enigmatic lesion. The spindle cells found in this tumor have features of myofibroblasts. Because the indefinite relationship these lesions with inflammatory fibrosarcoma their biologic behavior, currently classified as myofibroblastic (IMT). To date, only case reports or small series been published on tumors, which are primary spleen. Design.—In study, we describe clinical, morphologic, immunophenotypic findings 12 cases splenic...
Abstract Background: The t(11;14)(q13;q32) translocation present in the majority of mantle cell lymphomas (MCLs) places cyclin D1 gene under control immunoglobulin transcriptional regulatory elements, causing overexpression D1. Quantification expression can distinguish MCL from other lymphomas. Methods: A quantitative real-time reverse transcription (RT)-PCR assay was developed for mRNA suitable use with RNA extracted fresh and formalin-fixed, paraffin-embedded tissues. Specimens were...
PURPOSE: To retrospectively review clinical, pathologic, and imaging features of angiosarcoma the spleen in 12 patients. MATERIALS AND METHODS: Institutional board approval was obtained, informed consent not required. Records cases proved were accessed from files Armed Forces Institute Pathology. Clinical, findings reviewed. Presenting signs symptoms recorded, pathologist confirmed diagnosis determined gross microscopic morphologic each spleen. Radiologists reviewed available images to...
The objective of this study was to describe the CT and MRI features sclerosing angiomatoid nodular transformation spleen with pathologic correlation.Nine patients surgically resected pathologically confirmed were included in study. Clinical history reviewed determine patient demographics symptoms at presentation. Gross pathologic, histologic, immunohistochemical findings recorded. (n = 9) 4) examinations evaluated for lesion shape margins, intrinsic characteristics, enhancement...
Department of Pathology, University Virginia, Charlottesville, VA Conflicts Interest and Source Funding: The authors have disclosed that they no significant relationships with, or financial interest in, any commercial companies pertaining to this article.
Epstein-Barr virus (EBV) has been strongly linked with African Burkitt’s lymphoma and nasopharyngeal carcinoma (NPC) recently associated breast cancer (1). Nine studies of EBV in the use different methods (1–9) present conflicting results. In current study, microdissected ductal carcinomas were tested for EBV. Only one 115 cases was positive. This finding stands contrast to results showing up 48% positivity by polymerase chain reaction (PCR). Bonnet et al. (1) found 51 100 cancers all types...
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasocentric process characterized by infiltrates of lymphocytes and eosinophils, usually affecting the muscular arteries head neck. Currently it unclear whether reactive or neoplastic process.We present 61-year-old African American male twenty year history superficial skin patches involving neck region. An excisional biopsy right submental lymph node revealed an atypical T-cell lymphocytic process, diagnosed as peripheral lymphoma after...
Abstract Context.—c-kit, a proto-oncogene, encodes the transmembrane tyrosine kinase receptor CD117 and is detected by flow cytometry in majority of cases acute myeloid leukemia. The prognostic significance presence c-Kit leukemia debated. Recently, c-kit inhibitors have been studied as possible therapies against hematopoietic malignancies; therefore, detection may important implications for treatment. Objectives.—In this study, we investigated expression granulocytic sarcoma (GS) using...
This study aimed to identify and evaluate molecular targets for the development of a novel combination chemotherapy treat refractory recurrent diffuse large B-cell lymphoma (DLBCL).Lymphoma samples from 38 cases primary DLBCL were analyzed using real-time quantitative PCR RPS6KB1 CDC2 genes, immunohistochemistry their gene products p70S6K/p85S6K cdc2/cdk1. The Farage, Karpas422, Pfeiffer, Toledo cell lines subsequently treated with rapamycin UCN-01 alone or in combination. Cell...
Abstract Context.—c-kit, a proto-oncogene, encodes the transmembrane tyrosine kinase receptor CD117 and is detected by flow cytometry in majority of cases acute myeloid leukemia. The prognostic significance presence c-Kit leukemia debated. Recently, c-kit inhibitors have been studied as possible therapies against hematopoietic malignancies; therefore, detection may important implications for treatment. Objectives.—In this study, we investigated expression granulocytic sarcoma (GS) using...
We describe the clinical, histologic, immunophenotypic, and genotypic features of five cases histologically discordant lymphomas with B-cell T-cell components. Three patients presented lymphoma; lymphoma subsequently developed. One patient synchronous lymphomas. There were three men two women. The median age at initial diagnosis was 66 years. mean interval between development 83 months. All died disease. survival 96 months after 14 lymphoma. Epstein-Barr virus found in cases—the who...