A5031901881- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Academic Research in Diverse Fields
- Tendon Structure and Treatment
- Knee injuries and reconstruction techniques
- Exercise and Physiological Responses
- Healthcare and Venom Research
- Eosinophilic Esophagitis
- Complementary and Alternative Medicine Studies
- Osteoarthritis Treatment and Mechanisms
- Phytochemistry Medicinal Plant Applications
- Radiation Therapy and Dosimetry
- Business and Management Studies
- Multiple Myeloma Research and Treatments
- Advanced Radiotherapy Techniques
- Education during COVID-19 pandemic
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Seaweed-derived Bioactive Compounds
- Echinoderm biology and ecology
- Radiation Effects and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Healthcare during COVID-19 Pandemic
Universidade Federal do Ceará
2015-2023
Universidade Federal de São Carlos
2022
Universidade de São Paulo
2013-2022
Universidade de Ribeirão Preto
2013-2020
Abstract Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action paclitaxel based on microtubule stabilization inducing cell-cycle arrest. Here, we use models show that not only induces arrest, but also promotes antitumor immunity. In vitro, reprogrammed M2-polarized macrophages the M1-like phenotype in a TLR4-dependent manner, similarly LPS. modulated tumor-associated macrophage (TAM) profile mouse breast and melanoma tumors;...
Neuroimmune-glia interactions have been implicated in the development of neuropathic pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity inflammatory conditions central nervous system (CNS). Thus, we hypothesized IL-27 would participate pain process. Here, found caused by peripheral nerve injury (spared model; SNI), was enhanced deficient (-/-) mice, whereas nociceptive similar to wild type mice. SNI induced an increase expression and its receptor subunit (Wsx1)...
Cryotherapy is a non-pharmacological treatment commonly used to control inflammation and improve function after acute traumas. However, there are no definitive findings about its effects on chronic joint diseases such as knee osteoarthritis (KOA). The aim of this study was investigate the clinical-like cryotherapy functional impairment synovial in rat model KOA generated by anterior cruciate ligament transection (ACLT). Thirty-two male Wistar rats were randomly divided into four groups (n =...
Abstract Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion (DRG), expressed...
Paclitaxel (PCX) is the first-line choice for treatment of several types cancer, including breast, ovarian, and lung cancers. However, patients who receive even a single dose with PCX commonly develop mechanical cold allodynia, symptom known as PCX-associated acute pain syndrome (P-APS). Here, we assessed possible involvement kinin-kallikrein renin-angiotensin systems in P-APS mice.Male mice C57Bl/6 wild type (WT) knockouts bradykinin receptors, B1 (B1-/- ) B2 (B2-/- ), were used. Mechanical...
Nonerosive reflux disease (NERD) is a highly prevalent phenotype of the gastroesophageal disease. In this study, we developed novel murine model NERD in mice with microscopic inflammation and impairment epithelial esophageal barrier. Female Swiss were subjected to following surgical procedure: transitional region between forestomach glandular portion stomach was ligated, nontoxic ring placed around duodenum near pylorus. The control group underwent sham surgery. animals euthanized at 1, 3,...
To assess the effects of clinical-like cryotherapy on inflammatory signs ( in vivo neutrophil migration, cytokines, and joint inflammation), pain, swelling, balance, motor coordination mice with knee arthritis. Young C57BL/6 were randomly divided into three groups (8 to 10 per group): Control group: no intervention; antigen-induced arthritis (AIA) sensitized immunized intra-articular (i.a.) injection methylated bovine serum albumin (mBSA); AIA + sensitized, i.a. mBSA, submitted a protocol....
Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Abstract Background Assess the effect of clinical-like cryotherapy on inflammatory signs (in vivo neutrophil migration, cytokines and joint inflammation), pain, swelling in mice with knee arthritis. Balance motor coordination were also evaluated. Methods Young C57BL/6 randomly divided into 3 groups (n = 10/group): control group: animals not immunized antigen-induced arthritis (AIA) no intervention occurred; AIA methylated bovine serum albumin (mBSA) for arthritis; + mBSA submitted to...
Oxaliplatin (OXL) is a third generation platinum compound with potent cytotoxic activity against various types of cancer, like ovary, colorectal and lung cancer. Its toxicity differs from others agents, such as carboplatin cisplatin, since it less hematotoxic nefrotoxic. However, severe peripheral neuropathy stands side effect that complicates treatment limits dose. Microglia has maintenance role neuroprotective effect, but these cells may also contribute to neuropathic pain processing by...
<div>Abstract<p>Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion...
Supplementary Figure from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling
<div>Abstract<p>Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral neuropathy, is often observed. Here, we investigated role programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis modulation paclitaxel-induced neuropathic pain. We found that human mouse neural tissues, including dorsal root ganglion...
Supplementary Figure from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling