A5101838799- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Plant-based Medicinal Research
- Neuropeptides and Animal Physiology
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Chemotherapy-related skin toxicity
- Oral health in cancer treatment
- Biological Activity of Diterpenoids and Biflavonoids
- Silymarin and Mushroom Poisoning
- Stress Responses and Cortisol
- Neutropenia and Cancer Infections
- Complementary and Alternative Medicine Studies
- Soft tissue tumor case studies
- Gastrointestinal Tumor Research and Treatment
- Bone health and treatments
- Parkinson's Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Chemotherapy-induced organ toxicity mitigation
- Plant-derived Lignans Synthesis and Bioactivity
- Osteoarthritis Treatment and Mechanisms
- Brain Metastases and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Phytochemistry Medicinal Plant Applications
Universidade Federal do Ceará
2013-2024
Hospital Braga
2024
Background Oxaliplatin, the third-generation platinum compound, has evolved as one of most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor oxaliplatin treatment is painful neuropathy that difficult to treat. This side effect been studied for several years, but its full mechanism still inconclusive, and effective does not exist. Data suggest oxaliplatin's initial neurotoxic peripheral oxidative stress-dependent. A spinal target also suggested action....
Interindividual variation in drug efficacy and toxicity is a significant problem, potentially leading to adverse clinical economic public health outcomes. While pharmacogenetics pharmacogenomics have long been considered the primary causes of such heterogeneous responses, pharmacomicrobiomics has recently gained attention. The microbiome, community microorganisms living or on human body, critical determinant response toxicity. Factors as diet, lifestyle, exposure xenobiotics, antibiotics...
Severe diarrhoea, a common gastrointestinal manifestation of anticancer treatment with irinotecan, might involve single nucleotide polymorphisms (SNPs) toll-like receptors (TLRs), described as critical bacterial sensors in the gut. Here, colorectal cancer patients carrying missense TLR4 A896G (rs4986790) or C1,196T (rs4986791) SNPs and Tlr4 knockout (Tlr4-/-) mice were given irinotecan to investigate severity induced diarrhoea.Forty-six treated irinotecan-based regimens had diarrhoea...
Abstract This study aimed to evaluate the effects of inhibitors fractalkine pathway in hyperalgesia inflammatory and neuropathic orofacial pain male rats morphological changes microglia satellite glial cells (SGCs). Rats were submitted zymosan‐induced arthritis temporomandibular joint or infraorbital nerve constriction, treated intrathecally with a P 2 X 7 antagonist, cathepsin S inhibitor p‐38 mitogen‐activated protein kinase (MAPK) inhibitor. Mechanical was evaluated 4 6 h following...
Sensory neuropathy is a dose-limiting side effect of oxaliplatin-based cancer treatment. This study investigated the antinociceptive amifostine and its potential neuroprotective mechanisms on oxaliplatin-related peripheral sensory in mice. Oxaliplatin (1 mg/kg) was injected intravenously Swiss albino male mice twice week (total nine injections), while (1, 5, 25, 50, 100 administered subcutaneously 30 min before oxaliplatin. Mechanical thermal nociceptive tests were performed once for 49...
The canonical Wnt pathway participates in inflammatory diseases and it is involved neuropathic pain. This study evaluated the immunoexpression of signaling articular cartilage temporomandibular joint (TMJ) along nociceptive trigeminal arthritic rats. For this, male Wistar rats were divided into Control (C) Arthritic (RA) groups. Arthritis induction was performed through subcutaneous injection methylated bovine serum albumin (mBSA) complete Freund Adjuvant (CFA)/ Incomplete (IFA) on first 14...
To recognize changes that occur along the trigeminal pathway in oral cancer order to establish an effective approach pain control.Wistar rats were divided into control and 4-NQO groups for 8, 12, 16, or 20 weeks. suspension was administered on animals' tongues. Mechanical hyperalgesia, assessment of facial expressions, open-field test performed. After euthanasia, tongues removed macro- microscopic analysis. c-Fos expression analyzed structures.4-NQO induced time-dependent macroscopic lesions...
Oxaliplatin (OXL) is a third generation platinum compound with potent cytotoxic activity against various types of cancer, like ovary, colorectal and lung cancer. Its toxicity differs from others agents, such as carboplatin cisplatin, since it less hematotoxic nefrotoxic. However, severe peripheral neuropathy stands side effect that complicates treatment limits dose. Microglia has maintenance role neuroprotective effect, but these cells may also contribute to neuropathic pain processing by...
Abstract Hemorrhagic cystitis is a side effect of chemotherapy induced by an antineoplastic agent from the oxazaphosphorine group (ifosfamide and cyclophosphamide), resulting formation urotoxic metabolite acrolein. Morinda citrifolia Linn., popularly known as noni, species Rubiaceae, where it used root to fruit for therapeutic purposes. From seeds, thermostable protein called McLTP 1 (9.4 kDa) was extracted, among its effects, showed anti-inflammatory, gastroprotective, antibacterial...
e12595 Background: Breast cancer is one of the most frequent neoplasms worldwide, contributing to women's morbimortality. Triple-negative breast (TNBC) a highly aggressive subtype marked by negative estrogen receptors, progesterone and lack human epidermal growth factor 2 (C-erbB2, HER2/neu) gene overexpression. The high mobility group box-1 (HMGB1) that regulates malignant tumorigenesis, proliferation, metastasis. Aim: Here, HMGB1 expression was investigated as prognostic for TNBC. Methods:...