A5032074218- Essential Oils and Antimicrobial Activity
- Trypanosoma species research and implications
- Wound Healing and Treatments
- Antimicrobial Peptides and Activities
- Glycosylation and Glycoproteins Research
- Tea Polyphenols and Effects
- Hormonal Regulation and Hypertension
- Colorectal Cancer Surgical Treatments
- Natural product bioactivities and synthesis
- Animal Genetics and Reproduction
- Immune cells in cancer
- Biochemical and Structural Characterization
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Bioactivity Studies
- Transgenic Plants and Applications
- Ethnobotanical and Medicinal Plants Studies
- Ginkgo biloba and Cashew Applications
- Carbohydrate Chemistry and Synthesis
- Piperaceae Chemical and Biological Studies
- Galectins and Cancer Biology
- Silk-based biomaterials and applications
- SARS-CoV-2 and COVID-19 Research
- Advancements in Transdermal Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
Universidade de São Paulo
2022-2025
Institute of Biomedical Science
2024
Centro Universitário do Maranhão
2018-2021
Instituto Nacional do Câncer
2014
Escherichia coli and Staphylococcus aureus are important agents of urinary tract infections that can often evolve to severe infections. The rise antibiotic-resistant strains has driven the search for novel therapies replace use or act as adjuvants antibiotics. In this context, plant-derived compounds have been widely investigated. Cuminaldehyde is suggested major antimicrobial compound cumin seed essential oil. However, effect not fully understood. Herein, we investigated in silico vitro...
Staphylococcus aureus is recognized as an important pathogen causing a wide spectrum of diseases. Here we examined the antimicrobial effects lectin isolated from leaves Schinus terebinthifolia Raddi (SteLL) against S. using in vitro assays and infection model based on Galleria mellonella larvae. The actions SteLL mice macrophages aureus-infected were also evaluated. at 16 µg/mL (8 × MIC) increased cell mass DNA content relation to untreated bacteria, suggesting that impairs division. Unlike...
The occurrence of damage on bacterial DNA (mediated by antibiotics, for example) is intimately associated with the activation SOS system. This pathway related to development mutations that might result in acquisition and spread resistance virulence factors. inhibition response has been highlighted as an emerging resource, order reduce emergence drug tolerance. Herein, we evaluated ability betulinic acid (BA), a plant-derived triterpenoid, its phenotypic alterations, induced ciprofloxacin...
In 2019, the world witnessed onset of an unprecedented pandemic. By February 2022, infection by SARS-CoV-2 has already been responsible for death more than 5 million people worldwide. Recently, we and other groups discovered that induces ER stress activation unfolded protein response (UPR) pathway. Degradation misfolded/unfolded proteins is essential element proteostasis occurs mainly in lysosomes or proteasomes. The N-terminal arginylation characterized as inducer ubiquitination proteasomal...
(Aubl), commonly known as "mirim", is a plant of the Humiriaceae family, which consists 39 species divided between eight genera:
Staphylococcus aureus is commonly found in wound infections where this pathogen impairs skin repair. The lectin isolated from leaves of Schinus terebinthifolius (named SteLL) has antimicrobial and antivirulence action against S. aureus. This study evaluated the effects topical administration SteLL on mice wounds infected by Seventy-two C57/BL6 (6−8 weeks old) were allocated into four groups: (i) uninfected wounds; (ii) wounds, (iii) treated with 32 µg/mL solution; (iv) 64 solution....
Glycosylation is one of the most structurally and functionally diverse co- post-translational modifications in a cell. Addition removal glycans, especially to proteins lipids, characterize this process which has important implications several biological processes. In mammals, repeated enzymatic addition sialic acid unit underlying acids (Sia) by polysialyltransferases, including ST8Sia2, leads formation sugar polymer called polysialic (polySia). The functional relevance polySia been...
Main protease (Mpro), also known as 3-chymotrypsin-like (3CLpro), is a nonstructural protein (NSP5) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the cleavage virus polyproteins during viral replication at 11 sites, which generates 12 functional proteins. Mpro cysteine that presents specificity amino acid residue glutamine (Gln) P1 position substrate. Due to its essential role in processing polyprotein particle formation (assembly), inhibition has become an...
ABSTRACT Glycosylation is one of the most structurally and functionally diverse co- post-translational modifications in a cell. Addition removal glycans, especially to proteins lipids, characterize this process which have important implications several biological processes. In mammals, repeated enzymatic addition sialic acid unit underlying acids (Sia) by polysialyltransferases, including ST8Sia2, leads formation sugar polymer called polysialic (polySia). The functional relevance polySia has...
Staphylococcus aureus tem sido destacado devido sua capacidade de expressar uma variedade fatores virulência e adquirir resistência aos agentes antimicrobianos, resultando em um largo espectro doenças que são cada vez mais difíceis serem tratadas. Além disso, número maior linhagens S. demonstrado antimicrobianos; por esta razão, resistente à meticilina (MRSA) multirresistente (MDRSA) têm reconhecidos como as principais causas infecções hospitalares. O objetivo deste trabalho foi apresentar...