A5070496596- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Endoplasmic Reticulum Stress and Disease
- Photodynamic Therapy Research Studies
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- HER2/EGFR in Cancer Research
- TGF-β signaling in diseases
- Protease and Inhibitor Mechanisms
- Diet, Metabolism, and Disease
- Cytokine Signaling Pathways and Interactions
- Genetics and Neurodevelopmental Disorders
- Glycosylation and Glycoproteins Research
- FOXO transcription factor regulation
- Mesenchymal stem cell research
- Galectins and Cancer Biology
- Cancer, Lipids, and Metabolism
- Pregnancy and preeclampsia studies
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
Universidade de São Paulo
2015-2025
Experimental Medicine and Biology Institute
1999-2023
Universidade Cidade de São Paulo
2022
Universität Ulm
2019
Instituto de Química y Fisicoquímica Biológicas
2012
Consejo Nacional de Investigaciones Científicas y Técnicas
2002
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Abstract Background Metastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue inhibitors of MMPs (TIMPs), membrane-associated MMP inhibitor (RECK), are essential metastatic process. We have previously shown a positive correlation between expression during progression; however, molecular mechanisms underlying this coordinate regulation remain unknown. In report, we investigated whether TGF-β1 could be...
Breast cancer is the main cause of mortality among women. The disease presents high recurrence mainly due to incomplete efficacy primary treatment in killing all cells. Photodynamic therapy (PDT), an approach that causes tissue destruction by visible light presence a photosensitizer (Ps) and oxygen, appears as promising alternative could be used adjunct chemotherapy surgery for curing cancer. However, PDT treat breast tumours well molecular mechanisms lead cell death remain unclear. In this...
Abstract Type 1 diabetes (T1D) results from β-cell destruction due to concerted action of both innate and adaptive immune responses. Pro-inflammatory cytokines, such as interleukin-1β interferon-γ, secreted by the cells invading islets Langerhans, contribute pancreatic death in T1D. Cytokine-induced endoplasmic reticulum (ER) stress plays a central role demise. ER can modulate autophagic response; however, no study addressed regulation autophagy during pathophysiology In this study, we...
IL-1 axis activation during placental malaria induces poor pregnancy outcomes that are obliterated after treatment with Anakinra.
Abstract Adult mesenchymal stromal cell-based interventions have shown promising results in a broad range of diseases. However, their use has faced limited effectiveness owing to the low survival rates and susceptibility environmental stress on transplantation. We describe cellular molecular characteristics multilineage-differentiating stress-enduring (Muse) cells derived from adipose tissue (AT), subpopulation pluripotent stem isolated human lipoaspirates. Muse-AT were efficiently obtained...
Abstract Lack of effective treatments for aggressive breast cancer is still a major global health problem. We have previously reported that photodynamic therapy using methylene blue as photosensitizer (MB-PDT) massively kills metastatic human cancer, marginally affecting healthy cells. In this study, we aimed to unveil the molecular mechanisms behind MB-PDT effectiveness and specificity towards tumor Through lipidomics biochemical approaches, demonstrated efficiency rely on polyunsaturated...
The present study addresses the capacity of heregulin (HRG), a ligand type I receptor tyrosine kinases, to transactivate progesterone (PR). For this purpose, we studied, on one hand, an experimental model hormonal carcinogenesis in which synthetic progestin medroxyprogesterone acetate (MPA) induced mammary adenocarcinomas female BALB/c mice and, other human breast cancer cell line T47D. HRG was able exquisitely regulate biochemical attributes PR way that mimicked activation by progestins....
// Lilian Fedra Castillo 1, * , Rocío Tascón 1 María Amparo Lago Huvelle 2, Gisela Novack Candelaria Llorens 3, Ancely Ferreira dos Santos 4 Jorge Shortrede Ana Cabanillas Elisa Bal de Kier Joffé Leticia Labriola Giselle Peters Universidad Buenos Aires, Instituto Oncología “Ángel H. Roffo”, Area Investigación, Argentina 2 CONICET, Química Biológica la Facultad Ciencias Exactas y Naturales (IQUIBICEN), Naturales, 3...
ABSTRACT Coronavirus disease-2019 (COVID-19) pandemic caused by the SARS-CoV-2 coronavirus infection is a major global public health concern affecting millions of people worldwide. The scientific community has joint efforts to provide effective and rapid solutions this disease. Knowing molecular, transmission clinical features disease paramount importance develop therapeutic diagnostic tools. Here, we evidence that hijacks glycosylation biosynthetic, ER-stress UPR machineries for viral...
Abstract Photodynamic therapy (PDT) appears as a promising alternative in the treatment of breast cancer since it can be highly effective curing while preserving normal tissue. However, predicting outcomes PDT still constitutes great challenge. One parameters that are usually empirically determined is rate photon flux delivered to tissue (light fluence rate). In present study, we intended understand why monolayers human cells derived from mammary adenocarcinomas (MDA‐MB‐231 and MCF‐7)...
NADPH oxidase (NOX) is a known source of superoxide anions in phagocytic and non-phagocytic cells. In this study, the presence enzyme human pancreatic islets importance β-cell function were investigated.In isolated islets, expression components was evidenced by real-time PCR (p22(PHOX), p47(PHOX) p67(PHOX)), Western blotting (p47(PHOX) p67(PHOX)) immunohistochemistry (p47(PHOX), p67(PHOX) gp91(PHOX)). Immunohistochemistry experiments showed co-localization p47(PHOX), gp91(PHOX) (isoform 2...
Maintaining islet cell viability in vitro, although challenging, appears to be a strategy for improving the outcome of pancreatic transplantation. We have shown that prolactin (PRL) leads beta-cell cytoprotection against apoptosis, an effect mediated by heat shock protein B1 (HSPB1). Since role HSPB1 beta-cells is still unclear and hormone concentration used not compatible with clinical applications because all side effects displayed other tissues, we explored molecular mechanisms which...
Strategies to differentiate progenitor cells into beta in vitro have been considered as an alternative increase cell availability prior transplantation. It has recently suggested that nestin-positive could be multipotential stem capable of expressing endocrine markers upon specific stimulation; however, this issue still remains controversial. Here, we characterized short- and long-term islet cultures derived from three different human preparations, with respect expression nestin markers,...
Abstract Photodynamic therapy (PDT) has been clinically applied to cure various diseases including cancer. Indeed, photophrin (porfimer sodium, Axcan Pharma, Montreal, Canada), a heterogenous mixture of porphyrins, was the first photosensitizer (PS) approved for treatment human bladder cancer in 1993 Canada. Over past 10 years use PDT benign and malignant lesions increased dramatically. However, is still considered as an adjuvant strategy due its limitations, primarily low tissue penetration...
Abstract Heregulin (HRG) and type I receptor tyrosine kinase (RTK) expression was investigated in the highly invasive metastatic LM3 cell line, our previously described model of metastasis for mammary cancer (Bal de Kier Joffe et al. [1986] Invasion Metastasis 6:302–12; Urtreger [1997] Int J Oncol 11:489–96). Although cells do not express HRG, they exhibit high levels ErbB‐2 ErbB‐3 as well moderate ErbB‐4. Addition exogenous HRGβ1 resulted inhibition both proliferation migration cells. also...
Malaria in pregnancy is a public health concern malaria-endemic areas. Accumulation of maternal immune cells the placenta and increased levels inflammatory cytokines caused by sequestration