A5062238230- Computational Drug Discovery Methods
- Biotechnology and Related Fields
- SARS-CoV-2 and COVID-19 Research
- Diverse Scientific Research Studies
- Phytochemistry and Biological Activities
- COVID-19 Clinical Research Studies
- Transgenic Plants and Applications
- Healthcare Regulation
- Diet, Metabolism, and Disease
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plant Research
- Moringa oleifera research and applications
- Enzyme Production and Characterization
- Andrographolide Research and Applications
- Plant-based Medicinal Research
- Science and Education Research
- Antioxidants, Aging, Portulaca oleracea
- Medicinal Plants and Bioactive Compounds
Universidade Federal do Maranhão
2020-2024
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2019) etiological agent, which has a high contagiousness and is to blame for the outbreak of viral pneumonia, cause disease COVID-19. use natural products grew as an alternative treatment various diseases due abundance organic molecules with pharmacological properties. Many pharmaceutical studies have focused on investigating compounds therapeutic potential. Therefore, this study aimed identify potential antiviral from popular...
Introduction: Acute severe respiratory syndrome SARS-COV-2, a member of the coronavirus family enveloped RNA viruses, is disease-causing agent COVID-19. Research has been done on active components medicinal plants that have therapeutic promise. In this regard, goal work was to investigate anti-SARS-CoV-2 activity compounds from plant Bryophyllum pinnatum (Lam.) Oken.
 Materials and Methods: The methodology involved selection chemical constituents leaves in Pubchem database, addition...
Introduction: The new coronavirus SARS-CoV-2, identified in December 2019 as the cause of COVID-19, has triggered an outbreak potentially fatal atypical pneumonia. constant search for molecules or strategies to combat this disease continues. Thus, objective work was evaluate, using silico methods, compounds present Dipteryx odorata inhibitors crucial targets SARS-COV-2.
 Methodology: methodology included selection plant from Pubchem database and obtaining structures SARS-COV-2 proteins...
SARS-CoV-2 (severe acute respiratory distress syndrome coronavirus 2) is the causative agent for novel disease 2019 (COVID-19). It raises serious biosecurity questions due to its high contagious potential, thereby triggering rapid and efficient responses by scientific community take necessary actions against viral infections. Cumulative evidence suggests that natural products remain one of main sources pharmaceutical consumption. their wide chemical diversity they are able fight almost all...
O vírus COVID-2019, 2019-nCOV ou SARS-Cov-2 soma pouco mais de 290 mil casos e 12 mortes pelo mundo. Não existem estudos clínicos indicando tratamentos eficazes, a identificação agentes antivirais adequados constitui-se um passo crucial no combate à pandemia. presente trabalho constitui o levantamento proteínas do partir Protein Data Bank (PDB), elegíveis como alvos para docagem substâncias inibitórias. Posteriormente, foram realizados testes in sílico, com dois enzimáticos em interação os...
Highlights• Selection of drugs by scientific prospection for repositioning against SARS-CoV-2.• Molecular docking is used to predict the best fit between two molecules.• Obtaining pharmacokinetic meters through online tool pkCSM.
Chinese health agencies informed the World Health Organization (WHO) in December 2019 about an outbreak of pneumonia unknown etiology, attributed to a new virus called 2019-nCov, later named SARS-CoV-2 (the etiological agent COVID-19). These microorganisms, belonging family Coronaviridae and subfamily Coronavirinae, are formed by positive single-stranded RNA containing nucleocapsid spike proteins or spicules. They have high contamination rates, spread capacity, lethality rates directly...