A5102786269- Sarcoma Diagnosis and Treatment
- Gut microbiota and health
- Inflammatory Bowel Disease
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Advanced MRI Techniques and Applications
- Advances in Oncology and Radiotherapy
- Antibiotic Resistance in Bacteria
- Medical Imaging Techniques and Applications
- Immune responses and vaccinations
- Computational Drug Discovery Methods
- Colorectal and Anal Carcinomas
- Neuroinflammation and Neurodegeneration Mechanisms
- Surgical site infection prevention
- Advanced Radiotherapy Techniques
- Reconstructive Surgery and Microvascular Techniques
- Melanoma and MAPK Pathways
- Intracranial Aneurysms: Treatment and Complications
- Clostridium difficile and Clostridium perfringens research
- Radiomics and Machine Learning in Medical Imaging
- Wnt/β-catenin signaling in development and cancer
- Inflammasome and immune disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Vascular Tumors and Angiosarcomas
St Michael’s Hospital
2024
Medical University of South Carolina
2022-2024
Jackson Memorial Hospital
2020-2021
University of Miami
2019-2021
Sylvester Comprehensive Cancer Center
2019-2021
Jackson Health System
2019
Carilion Clinic
2019
University of Iowa
2014-2016
Universidad de Los Andes
2015
University of Alabama
2015
Background and Purpose— Cerebral aneurysm (CA) affects 3% of the population is associated with hemodynamic stress inflammation. Myeloperoxidase, a major oxidative enzyme inflammation, increased in patients CA, but whether myeloperoxidase contributes to CA not known. We tested hypotheses that within human critical for formation rupture mice. Methods— Blood was drawn from lumen CAs femoral arteries 25 who underwent endovascular coiling plasma concentrations were measured ELISA. Effects...
<title>Abstract</title> Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks known genetic etiology. To identify contributions to hEDS, whole exome sequencing was performed on families and cohort of sporadic hEDS patients. A missense variant in <italic>Kallikrein-15</italic> (KLK15 p. Gly226Asp<italic>)</italic>,<italic> </italic>segregated with disease two burden analyses 197 patients revealed enrichment variants within the...
Trametinib is a MEK1 (mitogen-activated extracellular signal-related kinase 1) inhibitor used in the treatment of BRAF (rapid accelerated fibrosarcoma B-type)–mutated metastatic melanoma. Roughly 11% patients develop cardiomyopathy following long-term trametinib exposure. Although described clinically, molecular landscape cardiotoxicity has not been characterized. The aim this study was to test hypothesis that promotes widespread transcriptomic and cellular changes consistent with oxidative...
Genetic discovery in very early-onset inflammatory bowel disease (VEO-IBD) can elucidate not only the origins of VEO-IBD, but also later-onset disease. We aimed to investigate polygenic VEO-IBD a cohort with high proportion Hispanic patients.
Macrophages play a central role in the inflammatory response leading to aneurysm formation, progression, and rupture. The purpose of this study was determine whether granulocyte-monocyte colony-stimulating factor (GM-CSF) plays progression human intracranial aneurysms. Specifically, we investigated there correlation between size concentration GM-CSF lumen concentrations blood samples drawn from 15 unruptured saccular aneurysms 14 consecutive patients were compared. 10.3±9 mm on average. mean...
Cancer is the second most common cause of death in United States, accounting for 602,350 deaths 2020. Cancer-related rates have declined by 27% over past two decades, partially due to identification novel anti-cancer drugs. Despite improvements cancer treatment, newly approved oncology drugs are associated with increased toxicity risk. These toxicities may be mitigated pharmacokinetic optimization and reductions off-target interactions. As such, there a need early-stage implementation (PK)...
Clostridioides difficile is a bacterial pathogen that has been implicated in severe gastrointestinal infections. C. intrinsic green autofluorescence and the level of this known to be increased by growth time oxygen. Currently, it unclear if dietary compounds or metabolites from gut microbiota are able enhance autofluorescence. Here, we aimed determine potential factors affect After screening large repertoire compounds, identified several substances, like L-lysine pantothenate, led an We also...
The intestine is a complex organ composed of the small and large intestines. can be further divided into duodenum, jejunum, ileum. Each anatomical region has unique function that reflected by differences in cellular structure. Investigating changes requires an in-depth analysis different tissue regions alterations. To study visualize pieces tissue, researchers commonly use technique known as intestinal Swiss rolls. In this technique, each fixed flat orientation. Then, carefully rolled...
Intestinal enterocytes have an elaborate apical membrane of actin-rich protrusions known as microvilli. The organization microvilli is orchestrated by the intermicrovillar adhesion complex (IMAC), which connects distal tips adjacent IMAC composed CDHR2 and CDHR5 well scaffolding proteins USH1C, ANKS4B, Myosin 7b (MYO7B). To create IMAC, cells must transport to membrane. 5b (MYO5B) a molecular motor that traffics ion transporters enterocytes, we hypothesized MYO5B may also be responsible for...
Abstract Background The standard glioblastoma treatment paradigm consists of surgery, pre-radiotherapy MRI, six weeks chemoradiotherapy, followed by post-radiotherapy MRI and continued adjuvant temozolomide. In a significant proportion patients, demonstrates tumor enlargement due to either failure (true progression) or response (pseudoprogression). Recently introduced MRI-guided radiotherapy systems obtain daily we hypothesized that progression can be identified early during radiotherapy....
<h3>Importance</h3> A large proportion of extremity soft-tissue sarcomas (ESS) occur among young adults, yet this group is underrepresented in clinical trials, resulting limited data on population. Younger patients present many complex challenges that affect management. <h3>Objective</h3> To investigate variations treatment management adults vs older with ESS. <h3>Design, Setting, and Participants</h3> This multicenter retrospective cohort study used the National Cancer Data Base (NCDB) to...
Background: Inflammatory bowel disease (IBD), which encompasses the subsets Crohn’s Disease and Ulcerative Colitis, is a life-long condition characterized by chronic inflammation of gastrointestinal tract. Multiple studies over last decade have implicated intestinal bacteria in initiation perpetuation IBD, but precise microbes contribute to remain unknown. Analysis 3,853 publicly available RNA-Seq datasets from 26 independent revealed that Acinetobacter calcoaceticus was one top 10 highest...
Abstract BACKGROUND Inflammatory bowel disease (IBD) is a life-long condition characterized by chronic inflammation of the gastrointestinal tract. Among potential causes IBD, gut microbiota has been implicated in perpetuating inflammation. Analysis IBD Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) database revealed that Acinetobacter calcoaceticus one top 10 highest elevated bacteria Crohn’s’ patients. are well-characterized for their antibiotic resistance, but little known...
Background: Colorectal cancer (CRC) is currently the third most prevalent worldwide and ranks as second deadliest. Colon characterized by disruption in cellular structure polarity, processes that are commonly regulated cell traffcking. The molecular motor Myosin 5b (Myo5b) a key component of intracellular traffcking intestinal epithelium. Myo5b moves along F-actin tracks to transport cargo from apical membrane. When function impaired, it leads significant changes gastrointestinal epithelial...
Background: The gut microbiota is known to impact multiple aspects of human health, including immune modulation, nutrient uptake, cell metabolism, and defense against pathogens. composition diversity the be altered in setting inflammatory bowel disease (IBD). IBD, which encompasses subsets Crohn’s Disease Ulcerative Colitis, a life-long condition characterized by chronic inflammation gastrointestinal tract. It has long been speculated that bacteria drive or exacerbate IBD patients, but few...
Abstract Background In the Dementia Friendly Hospital Guidelines 2018, it recommends we support patient safety, health and well-being. This can be facilitated by supporting diet, nutrition hydration in a calm, accessible usable space with appropriate lighting, clearly visible easily understood furniture tableware. We have audited our practices across hospital to ensure that promote all wards. As are an MDT team bring unique broad perspective on issue of availability, accessibility...
Intestinal tuft cells are rare that regulate diverse functions. They harbor chemosensory receptors and signal to the mucosal immune system in response external stimuli, though their full function structure remain unclear. Named for apical “tuft” of long actin-rich microvilli, facilitate chemoreception other physiological responses. In enterocytes, microvilli stabilized by intermicrovillar adhesion complexes (IMACs) composed several proteins, including cadherin-related family member-2 (CDHR2)...
Introduction Thymic carcinoma is a rare malignancy often presenting at an advanced stage. Radiosurgery and chemotherapy are the only treatment options available to physicians. Methods A 70-year old man presented with unresectable Stage III thymic tumor was treated 45Gy in 12 fractions followed by boost of 21.6 Gy fractions. He also bortezomib for multiple myeloma unrelated his primary malignancy. Results The patient made full recovery following radiation regimen remained disease free four...
Background: Colorectal cancer (CRC) is currently the third most common worldwide and second deadly cancer. CRC characterized by loss of cellular architecture altered polarity; features which can be controlled cell-trafficking. In intestine key cell trafficking pathways are Myosin 5b (MYO5B). Loss functional MYO5B leads to profound changes in gastrointestinal epithelial cells including increased proliferation, alterations tight junction proteins, decreased differentiation. For functional, it...