A5066775246- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Animal Virus Infections Studies
- Head and Neck Cancer Studies
- Virus-based gene therapy research
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Child Nutrition and Water Access
- Cervical Cancer and HPV Research
- Prostate Cancer Diagnosis and Treatment
- Whipple's Disease and Interleukins
- Animal Disease Management and Epidemiology
- Urinary and Genital Oncology Studies
- Advanced Radiotherapy Techniques
- Parvovirus B19 Infection Studies
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Treatment and Research
- Infant Nutrition and Health
- Statistical Methods in Clinical Trials
- Management of metastatic bone disease
- Health Systems, Economic Evaluations, Quality of Life
Instituto Adolfo Lutz
2015-2024
Precision Research Institute
2023
University of Miami
2021
Sylvester Comprehensive Cancer Center
2021
University of Pennsylvania
2018-2020
University of California, San Diego
2013-2015
Hospital Universitario de Gran Canaria Doctor Negrín
2013
Universidade de São Paulo
1990-2010
Public Health Dayton & Montgomery County
2010
Sorbonne Université
1998
In 2013, the equine-like G3P[8] DS-1-like rotavirus (RVA) strain emerged worldwide. 2016, this was reported in northern Brazil. The aims of study were to conduct a retrospective genetic investigation identify possible entry these atypical strains Brazil and describe their distribution across representative area country. From 2013 2017, total 4226 faecal samples screened for RVA by ELISA, PAGE, RT-PCR sequencing. represented 20.9 % (167/800) all RVA-positive samples, further subdivided as...
Abstract We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years age, before the introduction rotavirus vaccines. identified 117 and fit parametric to each country dataset mortality stratum. calculated median cumulative proportion gastroenteritis events expected occur at ages between birth 5.0 years. The hospital admissions was 38 weeks (interquartile range [IQR], 25–58 weeks) in countries very high child 65 (IQR, 40–107 low...
Regarding public health in Brazil, a new scenario emerged with the establishment of universal rotavirus (RV) vaccination programs. Herein, data from five years surveillance (2007-2012) G- and P-type RV strains isolated individuals acute gastroenteritis Brazil are reported. A total 6,196 fecal specimens were investigated by ELISA RT-PCR. RVs detected 19.1% (1,181/6,196). The peak incidence moved June-August to September. was less frequently (19.5%) among children ≤ 5 than older adolescents...
Abstract A total of 3,101 fecal specimens were collected during an 8-year survey for rotavirus infection in São Paulo, Brazil. Group was detected 774 (25.0%) specimens. Of these, 431 strains (55.7%) analyzed G and P types by reverse transcription–polymerase chain reaction; G1 the predominant serotype (68.2%), followed G9 (17.2%), G4 (6.3%), G2 (1.2%), G3 (0.7%), mixed (1.8%), untypeable (4.6%). Both could be established 332 (77.0%). We identified 4 most common worldwide: P[8]G1 (66.6%),...
The aim of this study was to monitor rotavirus (RV) infections in adults >18 years with acute gastroenteritis during 2004–2011 national Brazilian RV surveillance. In addition, characterize the group A (RVA) strains order gain insight into supposed vaccine selective pressure imposed children population. total 2102 convenient fecal specimens were investigated by ELISA, PAGE, and RT-PCR. detected 203 (9.6%) specimens, showed a marked peak detection September. RVA infection 9.4% (197/2102) C...
Rotavirus serotype G5 isolates were recently recovered from children with diarrhoea in Brazil. Like most human strains, they exhibited long electro- pherotypes and subgroup II Wa-like VP4 specificity. We report the successful propagation molecular antigenic characterization of one these (IAL-28). Cross-neutralization IAL-28 a single gene reassortant, UK × IAL- 28, which contains encoding VP7 genomic background, prototype G1 to G14 rotaviruses demonstrated that has determinants specific for...
Hand, foot and mouth disease (HFMD) is a contagious enteroviral infection occurring primarily in children characterized by vesicular palmoplantar eruptions erosive stomatitis. Echovirus 4 (EV-4) has been commonly associated with aseptic meningitis. The association of HFMD EV-4 not reported previously. Two samples 14-month child who presented mild fever, sores the mouth, rash blisters on palm hands soles feet were sent to Enteric Viruses Laboratory Adolfo Lutz Institute. Clinical inoculated...
Emergence of DS-1-like-G1P[8] rotavirus in Asia have been recently reported. We report for the first time detection and whole genome phylogenetic analysis strains America. From 2013 to 2017, a total 4226 fecal samples were screened by ELISA, PAGE, RT-PCR sequencing. G1P[8] represented 3.7% (30/800) all rotavirus-positive samples. comprised 1.6% (13/800) detected exclusively 2013, Wa-like-G1P[8] 2.1% (17/800) from 2015. Whole sequencing confirmed DS-1-like backbone I2-R2-C2-M2-A2-N2-T2-E2-H2....
Abstract From August 1994 to July 1995, 234 faecal samples from children with or without acute diarrhoea were collected and tested. The group of (A) was subdivided into two subgroups: subgroup A 1 made up severe diarrhoea, dehydrated who needed hospitalization 2 composed only outpatient care. Group B (controls). Rotavirus detected in 36.7% (18/49), 22.0% (15/68) 1.7% (2/117) patients groups , B, respectively. Of the 35 positive which rotaviruses VP7 genotypes G1, G2, G3, G5 mixture (G2 + G5)...
Surveillance for Enterovirus 71 (EV-71) infection in children up to 15 years of age was carried out Brazil, from 1988 1990. Patients with acute neurological diseases (AND) such as flaccid paralysis, Bell's palsy, cerebellar ataxia and Guillain-Barré syndrome were included the study. EV-71 detected 24 426 (5.6%) AND. confirmed only by virus isolation 13 children, seroconversion 4, alone 7. also isolated 427 household contacts (3.5%) 165 AND patients. There some evidence high infectivity...
Norovirus (NoV), previously called Norwalk-like virus, represents an important group of human pathogens associated with outbreaks nonbacterial gastroenteritis. Epidemiological surveys have shown that the most routes transmission are person-to-person contacts and contaminated food water, virus affecting adults children. NoV is classified into genogroups, being genogroups GI, GII GIV found in humans. In view high genetic diversity lack information about this Brazil, aim present study was...
Breast milk samples from three groups of Brazilian women were evaluated: G1, mothers delivering term babies low birth weight (n=16); G2, preterm appropriate (n = 20); G3, ( n 30). Milk obtained at 48 h and on the 7th, 15th, 30th 60th days after delivery they analyzed for lysozyme total IgA levels presence specific antibodies against Poliovirus types I, II, III, Rotavirus, Herpes simplex virus, Varicella zoster Cytomegalovirus. The not statistically different in relation to mother's age,...
Enteroviruses (EV) are most common cause of central nervous system (CNS) infection, mainly aseptic meningitis. In Brazil, data available concerning the distribution EV types scarce. The aim this study was to describe in patients with infection CNS São Paulo State. This retrospective conducted clinical samples collected from infections 2004 2014. We investigated presence by virus isolation cell culture. that showed cytopathic effect culture were submitted indirect immunofluorescence assay,...
In the context of near-global eradication wild poliovirus, significance non-polio enteroviruses (NPEVs) in causing acute flaccid paralysis (AFP) and their impact on public health has gained increased attention. This research, conducted from 2001 to 2021, examined stool samples 1597 children under 15 years São Paulo, Brazil, through AFP/Poliomyelitis Surveillance Program, detecting NPEVs 6.9% cases. Among 100 NPEV-positive strains analyzed, 90 were genotyped genomic sequencing partial VP1...
An aseptic meningitis outbreak occurred during a period from February to May 2004 in São Joaquim da Barra, town the northern region of Paulo State. A total 40 cases were reported Epidemiological Surveillance Center Cerebrospinal fluid samples obtained 23 patients sent Adolfo Lutz Institute for isolation virus. These inoculated into RD, HEp2 and Vero cell lineages those presenting cytopathogenic effect selected analysis by indirect immunofluorescence assay (IFA), neutralization testing (Nt)...