A5087044814- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Meningioma and schwannoma management
- Ear and Head Tumors
- Immune cells in cancer
- Sinusitis and nasal conditions
- Pituitary Gland Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Epigenetics and DNA Methylation
- Nonmelanoma Skin Cancer Studies
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Cleft Lip and Palate Research
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Ferroptosis and cancer prognosis
- Airway Management and Intubation Techniques
- Cervical Cancer and HPV Research
- Cancer survivorship and care
University of Miami
2016-2025
Sylvester Comprehensive Cancer Center
2014-2025
University of Miami Health System
2024-2025
Neurological Surgery
2024-2025
Jackson Memorial Hospital
2007-2021
University of Miami Hospital
2021
State of Illinois
2020
International Society of Nephrology
2020
Jackson Health System
2016
Saint Joseph University
2002-2004
Abstract Purpose: Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) play a key role in the progression of head neck squamous cell carcinoma (HNSCC). On basis our preclinical data demonstrating that phosphodiesterase-5 (PDE5) inhibition can modulate these populations, we evaluated whether PDE5 inhibitor tadalafil revert tumor-induced immunosuppression promote tumor immunity patients with HNSCC. Experimental Design: First, functionally phenotypically characterized MDSCs HNSCCs...
Background This study reports the combined experience of University Miami and Pittsburgh with endoscopic endonasal resection esthesioneuroblastoma (ENB). A retrospective case series review was performed in a tertiary care university hospital. Methods Twenty-three patients, 16 men 7 women, were reviewed. Mean age 56.6 years (15-79 years). Nineteen patients received primary anterior skull base resection. Of these, modified Kadish stage at presentation 2 B 11 C 5 D 1 patient. Three had revision...
Objective. To describe coronavirus disease 2019 (COVID-19) patient presentations requiring otolaryngology consultation and provide recommendations for protective measures based on the experience of ear, nose, throat (ENT) departments in 4 Chinese hospitals during COVID-19 pandemic. Study Design. Retrospective case series. Setting. Multicenter. Subjects Methods. Twenty hospitalized patients ENT from 3 designated Wuhan, Shanghai, Shenzhen were identified. Data demographics, comorbidities,...
Abstract Background Craniofacial resection (CFR) has been the standard of care for malignant tumors anterior skull base (ASB). However, during past 2 decades, transnasal endoscopic (TER) gained significant popularity. The purpose this study is to compare CFR and TER with respect perioperative oncologic outcomes. Methods Retrospective analysis at a tertiary medical center 82 consecutive patients undergoing ASB between 1997 2011. Results Thirty‐four underwent TER, while 48 CFR. There was no...
Myeloid Derived suppressor cells (MDSCs) play a key role in the progression and recurrence of human malignancies restraining efficacy adjuvant therapies. We have previously shown that Tadalafil lowers MDSCs regulatory T (Treg) blood tumor, primes tumor specific immune response, increases number activated intratumoral CD8+T patients with primary Head Neck Squamous Cell Carcinoma (HNSCC). However, despite these important modulatory actions, to date no clinically significant effects been...
Abstract Background No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT‐PCR) for novel coronavirus in preoperative screening. Methods Preoperative patients had one or two nasopharyngeal swabs, depending on low high risk of viral transmission. Positive tests were repeated. Results Forty‐three 52 required more tests. Four (9.3%) discrepant results (positive/negative). One these left the disease (COVID) unit against medical advice despite an orbital abscess,...
Abstract Human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (SCC) is a well‐known cause and prognostic indicator, the utility of p16 as surrogate marker for HPV status has been established. P16 its relationship with have not defined sinonasal malignancy nor link outcomes Patients SCC from 2011 to 2017 were identified our pathology database. immunohistochemistry RNA situ hybridization performed on tissue specimens. Forty‐seven patients included. Disease‐free survival p16+ was...
Objectives/Hypothesis To examine the significance of indeterminate fine needle aspiration biopsy in diagnosis parotid gland malignancy. Study Design Retrospective case series, academic tertiary referral center. Methods A total 559 parotidectomies performed between years 2005 and 2010 were reviewed, with 56.7% (N = 317) meeting investigation eligibility criteria: primary tumor, availability fine‐needle biopsy, intraoperative frozen section, final pathologic diagnosis. One‐hundred fifteen (n...
The behavior of advanced cutaneous squamous cell carcinoma the head and neck (HNcSCC) remains poorly understood, with highly variable risk factors a paucity data for adjuvant treatment. objective our study was to review oncologic outcomes patients high-risk HNcSCC treated surgery identify treatment failure.Retrospective cohort study.Retrospective definitive involving at least parotidectomy dissection tertiary care academic center from 2011 2017 conducted. primary outcome disease-free...
Abstract Emerging evidence suggests that not only the frequency and composition of tumor-infiltrating leukocytes but also their spatial organization might be a major determinant tumor progression response to therapy. Therefore, mapping analyzing fine immune architecture could potentially provide insights for predicting cancer prognosis. Here, we performed an explorative, prospective clinical study assess whether structures within microenvironment can predict recurrence after salvage surgery...
ABSTRACT Objective There is limited consensus on endoscopic skull base surgery (ESBS) reconstruction principles. This study aims to generate comprehensive themes regarding ESBS by pooling the experiences of experts, with comparison a literature review current published evidence. Methods Structured qualitative interviews experts postoperative management and various defect locations were conducted. Results A total 68 comprising 40 academic teams across 13 countries an average 18 years...
Objective To measure the association between race and head neck cancer screening education. Study Design Nationally representative survey. Setting US National Center for Health Statistics. Subjects Methods Pooled data from 2011‐2014 Nutrition Examination Survey were used to examine disparities in education among citizens aged ≥18 years. We measured screening, adjusting age, sex, education, income, health insurance. Subtype analyses performed on ever smokers, a lifetime consumption of ≥100...
Background It has become clear that healthcare workers are at high risk, and otolaryngology been theorized to be among the highest risk specialties for coronavirus disease 2019 (COVID‐19). The purpose of this study was detail international impact COVID‐19 otolaryngologists, identify instructional cases. Methods Country representatives Young Otolaryngologists–International Federation Otolaryngologic Societies (YO‐IFOS) surveyed otolaryngologists through various channels. Nationwide surveys...