A5083673967- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Lymphoma Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Cutaneous lymphoproliferative disorders research
- COVID-19 impact on air quality
- Manufacturing Process and Optimization
- T-cell and B-cell Immunology
- COVID-19 Pandemic Impacts
- Immune Cell Function and Interaction
- Animal Disease Management and Epidemiology
- COVID-19 epidemiological studies
- Cutaneous Melanoma Detection and Management
- Respiratory viral infections research
- Single-cell and spatial transcriptomics
- Biosensors and Analytical Detection
- Infectious Diseases and Mycology
- Immunotherapy and Immune Responses
Tunis El Manar University
2017-2023
Institut Pasteur de Tunis
2014-2023
Tunis University
2017-2023
University of Miami
2023
Abstract Emerging evidence suggests that not only the frequency and composition of tumor-infiltrating leukocytes but also their spatial organization might be a major determinant tumor progression response to therapy. Therefore, mapping analyzing fine immune architecture could potentially provide insights for predicting cancer prognosis. Here, we performed an explorative, prospective clinical study assess whether structures within microenvironment can predict recurrence after salvage surgery...
Aptamers are short single-stranded DNA (ssDNA), RNA or synthetic XNA molecules, which used as a class of affinity binders recognizing target molecules with very high and specificity. The aim this study was to generate characterize ssDNA aptamers for the detection Newcastle disease virus (NDV). These were selected using systematic evolution ligands by exponential enrichment (SELEX) in combination quantitative high-throughput sequencing. After three rounds selections, highly enriched pool...
Infectious bronchitis virus (IBV) is a coronavirus responsible for major health problems in the poultry industry. New strains continue to appear, causing large economic losses. To develop rapid and accurate new quantitative assay diagnosis of without DNA extraction, we selected highly specific single-stranded (ssDNA) aptamers with high affinity IBV, using systematic evolution ligands by exponential enrichment (SELEX) technology aptamer screening, followed high-throughput sequencing...
Detecting viral antigens at low concentrations in field samples can be crucial for early veterinary diagnostics. Proximity ligation assays (PLAs) both solution and solid-phase formats are widely used high-performance protein detection medical research. However, the affinity reagents used, which mainly poly- monoclonal antibodies, play an important role performance of PLAs. Here, we have established first homogeneous proximity-dependent DNA aptamer rapid accurate Newcastle disease virus...
In this article, we are interested in what extent and how the COVID-19 health crisis affects goal of sustainable development. So, after defining concept development its pillars, article recommends evaluating impact on sustainability And to answer question, chose a method that involves first reviewing theoretical literature subject then continuing study many goals.
<p>Numeric data describing a) sample composition, analysis parameters, and phenotyping; b) phenotype composition of the merged dataset each single sample; c) cell type (number cells) cellular neighborhoods identified at W=10 K=14; d) Number cells assigned to 11 e): relative cell-cell contact frequencies (RF) for all phenotypes in TLS1 TLS2 CNs across patients; f) hot cold tumor patients</p>
<p>supplementary figure S1-4</p>
<p>supplementary figure S1-4</p>
<div>Abstract<p>Emerging evidence suggests that not only the frequency and composition of tumor-infiltrating leukocytes but also their spatial organization might be a major determinant tumor progression response to therapy. Therefore, mapping analyzing fine immune architecture could potentially provide insights for predicting cancer prognosis. Here, we performed an explorative, prospective clinical study assess whether structures within microenvironment can predict recurrence...
<div>Abstract<p>Emerging evidence suggests that not only the frequency and composition of tumor-infiltrating leukocytes but also their spatial organization might be a major determinant tumor progression response to therapy. Therefore, mapping analyzing fine immune architecture could potentially provide insights for predicting cancer prognosis. Here, we performed an explorative, prospective clinical study assess whether structures within microenvironment can predict recurrence...
<p>Numeric data describing a) sample composition, analysis parameters, and phenotyping; b) phenotype composition of the merged dataset each single sample; c) cell type (number cells) cellular neighborhoods identified at W=10 K=14; d) Number cells assigned to 11 e): relative cell-cell contact frequencies (RF) for all phenotypes in TLS1 TLS2 CNs across patients; f) hot cold tumor patients</p>