A5020071575- Phytochemistry Medicinal Plant Applications
- Research on Leishmaniasis Studies
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Antioxidant Activity and Oxidative Stress
- Agricultural and Food Sciences
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Bee Products Chemical Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemical compounds biological activities
- Phytochemicals and Antioxidant Activities
- Psidium guajava Extracts and Applications
- Ethnobotanical and Medicinal Plants Studies
- Antimicrobial Peptides and Activities
- Natural product bioactivities and synthesis
- Phytochemicals and Medicinal Plants
- Piperaceae Chemical and Biological Studies
- Liver Disease Diagnosis and Treatment
- Traditional and Medicinal Uses of Annonaceae
- Nitric Oxide and Endothelin Effects
- Herbal Medicine Research Studies
- Trypanosoma species research and implications
- Natural Compound Pharmacology Studies
- Eicosanoids and Hypertension Pharmacology
Universidade Federal do Piauí
2016-2025
Universidade de Brasília
2024
Aarhus University
2015-2021
Aarhus University Hospital
2020
Aalborg University Hospital
2020
University of Exeter
2015
Dallas County
1981
Institute of Forensic Sciences
1981
This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities carvacrol, phenolic monoterpene constituent essential oils produced by oregano other several aromatic plants spices, in experimental models edema induced different phlogistic agents gastric lesions acetic acid. In paw dextran or histamine, carvacrol was effective at 50 mg/kg (46% 35%, respectively); these models, cyproheptadine reduced formation (61% 43%, respectively). substance P, (100 mg/kg)...
Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and endemic in many regions the globe. The currently available drugs present serious problems such as toxicity, costs, emergence drug resistance. This has stimulated research into new antileishmania based on natural products their derivatives. β-Ocimene monoterpene found naturally essential oils plant species which presents antileishmanial activity, not yet been evaluated for its potential to inhibit...
Two cases of acute overdose with isopropyl alcohol are reported. Blood concentrations the and its major metabolite, acetone, were measured during metabolism phase alcohol, acetone was elevated thirty-seven hours later in one case. Isopropyl disappeared from blood at a rate following first-order kinetics both cases. half-lives estimated 155 187 minutes two patients, respectively.
The brine shrimp (Artemia salina Leach) lethality bioassay offers an advantage in standardization and quality control of botanical products. This test is well correlated with antitumor activity (cytotoxicity) can be used to monitor the bioactive natural paper reports bioactivity ethanol extracts from seven medicinal plants Northeast Brazil (Acmella uliginosa, Ageratum conyzoides, Eugenia uniflora, Plectranthus neochilus, Moringa oleifera, Justicia pectoralis Equisetum sp.) against Artemia...
Myracrodruon urundeuva (Engl.) Fr. All., commonly known as "aroeira-do-sertão", is a medicinal plant from Anacardiaceae family. In this study, the chemical composition of M. essential oil (MuEO) was evaluated by gas chromatography-mass spectrometry (GC-MS), well its anti-Leishmania potential, cytotoxicity, and macrophage activation capability possible antiprotozoal mechanism action were assessed. Fourteen compounds identified, which constituted 94.87% total composition. The most abundant...
Silver nanoparticles have been studied as an alternative for treatment of microbial infections and leishmaniasis, without promoting induction or parasite resistance. In this study, chitosan-based silver were synthesized from nitrate (AgNO 3 ), sodium borohydride a reducing agent, the biopolymer chitosan capping agent. The characterized by ultraviolet–visible, Fourier transform infrared, dynamic light scattering, zeta potential, atomic force microscopy, transmission electron microscope....
Leishmaniasis is an infectious disease complex caused by protozoa from the Leishmania genus, which presents a broad spectrum of clinical manifestations: cutaneous, mucocutaneous and visceral forms. The current treatments are unsatisfactory considering that few drugs available present some level toxicity. Many lignans neolignans have been used for development new antileishmania drugs. capability in vitro neolignan 2,3-dihydrobenzofuran (2,3-DBF), commonly found constituent propolis other...
Bacuri (Platonia insignis) is a monotype belonging to the Clusiaceae family. Of Amazonian origin, it highly appreciated for fresh consumption, mainly due its peculiar sensory characteristics. It also widely used in food industry, pulp (endocarp), manufacture of beverages, jellies, and ice cream. Although use well established sector, recently, research has turned attention other parts fruit plant, especially therapeutics, cosmetics, fuel sectors. Its bioactive components have been...
Endogenous hydrogen sulfide (H<sub>2</sub>S) is involved in the regulation of vascular tone. We hypothesized that lowering calcium and opening potassium (K) channels as well calcium-independent mechanisms are H<sub>2</sub>S-induced relaxation rat mesenteric small arteries. Amperometric recordings revealed free [H<sub>2</sub>S] after addition to closed tubes sodium hydrosulfide (NaHS), Na<sub>2</sub>S, GYY4137 [<i>P</i>-(4-methoxyphenyl)-<i>P</i>-4-morpholinyl-phosphinodithioic acid] were,...
Metabolic syndrome, especially its component related to dyslipidemia, is the development of nonalcoholic fatty liver disease (NAFLD), which a with significant global prevalence. Supplementation omega-3 polyunsaturated acids emerged as complementary therapeutic possibility for but benefits are questioned. This paper aims at evaluating effects fish oil supplementation in rats hypercholesterolemia induced by hypercholesterolemic diet (HD). The study design based on an experimental model animals...
Hydrogels are structures that have value for application in the area of tissue engineering because they mimic extracellular matrix. Naturally obtained polysaccharides, such as chitosan (CH) and cashew gum, materials with ability to form polymeric networks due their physicochemical properties. This research aimed develop a scaffold based on phthalated tree gum test it support growth human mesenchymal stem cells. In this study, phthalation (PCG) was performed by using solvent-free route....
Anxiety is a normal behavioral component. When it too frequent or appears in inappropriate contexts, can be considered pathological. Benzodiazepines (BDZs) are drugs with clinical success anxiety treatment. BDZs act as allosteric modulators of the γ- aminobutyric acid A receptor (GABAAR). However, these cause adverse effects. Despite therapeutic advances obtained BDZs, search for anxiolytics fewer effects ongoing. Studies monoterpene (–)-borneol [(–)-BOR] demonstrated pharmacological...
Abstract: The monoterpene (−)‐borneol is present in essential oils of several medicinal plants. aim this study was to evaluate effects on rat thoracic aorta artery rings. cumulative addition (10 −9 –3 × 10 −4 M) a phenylephrine‐induced pre‐contraction −6 promoted vasorelaxant effect concentration‐dependent manner and independent vascular endothelium. A similar obtained KCl‐induced pre‐contractions (80 mM). (−)‐Borneol −5 inhibited contractions induced by CaCl 2 −2 depolarizing medium without...
Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae-Caesalpinioideae), popularly known in Brazil as "caneleiro", is widely used folk medicine against gastrointestinal diseases. In previous studies, the ethanol extract of leaves from had shown antinociceptive, anti-inflammatory, antibacterial, antioxidant and antiulcerogenic activities.The aim this study was to assess gastroprotective effect hydroalcoholic fraction (Cm-FHA), well elucidate possible underlying mechanisms...
The Lippia origanoides H.B.K. ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against a methicillin resistant Staphylococcus aureus (MRSA) strain. natural products did not show multidrug strain at the clinically significant concentrations tested. However, modulatory effect antibacterial of neomycin amikacin was verified when LOEE, LOHEX LODCM added to...
The intravascular parasitic worm Schistosoma mansoni is a causative agent of schistosomiasis, disease great global public health significance. Praziquantel the only drug available to treat schistosomiasis and there an urgent demand for new anthelmintic agents. Adopting phenotypic screening strategy, here, we evaluated antiparasitic properties 46 commercially cardiovascular drugs against S. mansoni. From these screenings, found that amiodarone, telmisartan, propafenone, methyldopa, doxazosin...