A5010658630- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Plant biochemistry and biosynthesis
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- Antimicrobial Peptides and Activities
- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- Parasitic Infections and Diagnostics
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Phytochemistry Medicinal Plant Applications
- Phytochemical compounds biological activities
- Synthesis and Catalytic Reactions
- Biochemical and Structural Characterization
- Legionella and Acanthamoeba research
- Vibrio bacteria research studies
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Bee Products Chemical Analysis
- Bacterial biofilms and quorum sensing
- Marine Bivalve and Aquaculture Studies
- Cardiovascular Issues in Pregnancy
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
Universidade de São Paulo
2021-2024
Universidade Municipal de São Caetano do Sul
2023
Universidade Federal do Triângulo Mineiro
2017-2021
The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout world. In recent years, peptide-based therapeutics have been widely studied developed to treat infectious diseases, including viral infections. Herein, antiviral effects of lysine linked dimer des-Cys11, Lys12,Lys13-(pBthTX-I)2K ((pBthTX-I)2K)) derivatives against SARS-CoV-2 are reported. lead peptide (pBthTX-I)2K showed attractive inhibitory activities (EC50 = 28–65 µM)...
We report a solvent- and metal-free methodology for the aminochalcogenation of alkenes, using I 2 /DMSO as catalytic system, under microwave irradiation. Some obtained compounds showed potent antiviral activity against coronavirus SARS-CoV-2.
SUMMARY Leishmaniasis is a complex of zoonotic diseases caused by parasites the genus Leishmania , which can develop in domestic as well wild animals and humans throughout world. Currently, this disease spreading rural urban areas non-endemic regions Brazil. Recently, bats have gained epidemiological significance leishmaniasis due to its close relationship with human settlements. In study, we investigated presence spp. DNA blood samples from 448 belonging four families representing 20...
The potential emergence of zoonotic diseases has raised significant concerns, particularly in light the recent pandemic, emphasizing urgent need for scientific preparedness. bioprospection and characterization new molecules are strategically relevant to research development innovative drugs viral bacterial treatment disease management. Amphibian species possess a diverse array compounds, including antimicrobial peptides. This study identified first bioactive peptide from Salamandra...
2019-n-CoV is the seventh coronavirus known to infect humans and cause serious illness, due its lethality there was a worldwide mobilization for development of new drugs vaccines Covid-19. Therefore, present work aims carry out virtual screening terpenes with potential anti SARS-CoV-2 activity. To perform ligand-based virtual, model constructed regarding compounds which already showed inhibitory activity SARS-CoV-2. The test series corresponded isolated in Fabaceae Family. that were most...
The deaths caused by the covid-19 pandemic have recently decreased due to a worldwide effort in vaccination campaigns. However, even vaccinated people can develop severe form of disease that requires ICU admission. As result, search for antiviral drugs treat these cases has become necessity. In this context, natural products are an interesting alternative synthetic medicines used drug repositioning, as they been consumed long time through traditional medicine. Many compounds found plant...
In 2019, the emergence of seventh known coronavirus to cause severe illness in humans triggered a global effort towards development new drugs and vaccines for SARS-CoV-2 virus. These efforts are still ongoing 2024, including present work where we conducted ligand-based virtual screening terpenes with potential anti-SARS-CoV-2 activity. We constructed Quantitative Structure–Activity Relationship (QSAR) model from compounds activity against accuracy 0.71. utilized this predict series 217...
Abstract Chagas Disease is a zoonosis caused by the parasite Trypanosoma cruzi . Several high-resolution markers have subdivided T. taxon into at least seven lineages or Discrete Typing Units (DTUs) (TcI-TcVI and TcBat). I most diverse geographically widespread DTU. Recently TcI genotype related to domestic cycles was proposed named as DOM. Herein, we combined traditional housekeeping genes applied Multispecies Coalescent method explore intra-TcI relationships, lineage boundaries genetic...
Few extracts of plant species from the Brazilian flora have been validated a pharmacological and clinical point view, it is important to determine whether their traditional use proven by effects. Cenostigma pluviosum var. peltophoroides one those plants, which belongs Fabaceae family that widely used in medicine very rich tannins. Due lack effective drugs treat severe cases Covid-19, main protease SARS-CoV-2 (Mpro) becomes an attractive target research for new antivirals since this enzyme...
Dendritic cells (DCs) are a type of antigen-presenting that play an important role in the immune response against Trypanosoma cruzi, causative agent Chagas disease. In vitro and vivo studies have shown modulation these by this parasite can directly affect innate acquired host order to facilitate its biological cycle spreading species. Many show mechanisms which T. cruzi modulates DCs, but interaction with Mexican strains such as Ninoa INC5 has not yet been properly investigated. Here, we...
Rhodnius neglectus is a potential vector of Trypanosoma cruzi (Tc), the causative agent Chagas disease. The salivary glands (SGs) and intestine (INT) are actively required during blood feeding. saliva from SGs injected into vertebrate host, modulating immune responses favoring feeding for INT digestion. Tc infection significantly alters physiology these tissues; however, studies that assess this still scarce. This study aimed to gain better understanding global transcriptional expression...
Abstract Congenital transmission of Chagas disease plays an important role in endemic countries because it is not a diagnosis that encountered frequently prenatal care. Due to limited information regarding congenital Trypanosoma cruzi Mexico, the present study aimed investigate protozoan infectivity and modulation immune responses human placental explants infected with T. Ia Mexican strains. The Inc-5 strain showed increased modulated IL-1 β , IL-10 TLR-4, decreasing their expression after...
Abstract In this study, trypanosomatids commonly found in bats, including Trypanosoma cruzi marinkellei, T. dionisii, and Leishmania braziliensis, were identified. Additionally, wauwau was identified one specimen of Anoura caudifer, represents the first report parasite from Central West region Brazil. previously by other researchers North country, only three species bats genus Pteronotus: P. parnellii (Pará Rondônia states), personatus gymnonotus (Rondônia). The identification indicates how...
Objetivo: Avaliar a presença de parasitos em amostras fezes e solo colhidas diferentes áreas no Município Ituiutaba-MG. Metodologia: Foram visitadas 17 praças coletadas um total 85 fezes, analisadas pelas técnicas parasitológicas flutuação, formol-éter sedimentação espontânea. As foram 20 locais entre clubes, sendo cinco cada local. acondicionadas sacos formando “pool do local”, identificadas com data temperatura encaminhadas para análise parasitológica. Resultados: Do 23,5% (20/85) estavam...