A5042517196- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- Malaria Research and Control
- Insect Resistance and Genetics
- Insect and Pesticide Research
- Bee Products Chemical Analysis
- Calcium signaling and nucleotide metabolism
- Phytochemistry Medicinal Plant Applications
- Diverse Scientific Research Studies
- Transgenic Plants and Applications
- Dengue and Mosquito Control Research
- Invertebrate Immune Response Mechanisms
- Insect Utilization and Effects
- Medicinal Plants and Neuroprotection
- Antimicrobial Peptides and Activities
- CRISPR and Genetic Engineering
- Insect Pest Control Strategies
Universidade de São Paulo
2014-2024
Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular
2016-2018
Abstract In an attempt to control the mosquito-borne diseases yellow fever, dengue, chikungunya, and Zika fevers, a strain of transgenically modified Aedes aegypti mosquitoes containing dominant lethal gene has been developed by commercial company, Oxitec Ltd. If lethality is complete, releasing this should only reduce population size not affect genetics target populations. Approximately 450 thousand males were released each week for 27 months in Jacobina, Bahia, Brazil. We genotyped release...
Background The worldwide expansion of new emergent arboviruses such as Chikungunya and Zika reinforces the importance in understanding role mosquito species spreading these pathogens affected regions. This knowledge is essential for developing effective programs based on specificity to avoid establishment endemic transmission cycles sustained by identified local vectors. Although first autochthonous virus was described 2014 north Brazil, main outbreaks were reported 2015 2016 northeast...
Aedes aegypti, the main vector of dengue virus, requires a blood meal to produce eggs. Although live animals are still source for laboratory colonies, many artificial feeders available. These also best method experimental oral infection Ae. aegypti with Dengue viruses. However, most them expensive or laborious construct. Based on principle Rutledge-type feeder, conventional conical tube, glycerol and Parafilm-M were used develop simple in-house feeder device. The feeding efficiency this...
The Zika virus outbreaks are unprecedented human threat in relation to congenital malformations and neurological/autoimmune complications. Since this has high potential spread regions presenting the vectors, improvement mosquito control is a top priority. Thus, Aedes aegypti laboratory strains will be fundamental support studies different research fields implicated on Zika-mosquito interactions which basis for development of innovative methods. In sense, our aim was determine main infection...
Angiotensin II (AII) as well analog peptides shows antimalarial activity against Plasmodium gallinaceum and falciparum , but the exact mechanism of action is still unknown. This work presents solid‐phase synthesis characterization eight corresponding to alanine scanning series AII plus amide‐capped derivative evaluation antiplasmodial these mature P. sporozoites. The Ala screening data indicates that replacement either Ile 5 or His 6 residues causes minor effects on in vitro compared with...
Ades aegypti is the most important arbovirus vector in world, and new strategies are under evaluation. Biological studies mentioning occurrence of a second mate Aedes can interfere with control program planning, which involves male mosquito release technique. This study presents different experiments to show mixed progeny. Mixed crosses (using combination type males confinement virgin females) showed no polyandric female. Individual substitution every gonotrophic cycle also did not any 20...
The deaths caused by the covid-19 pandemic have recently decreased due to a worldwide effort in vaccination campaigns. However, even vaccinated people can develop severe form of disease that requires ICU admission. As result, search for antiviral drugs treat these cases has become necessity. In this context, natural products are an interesting alternative synthetic medicines used drug repositioning, as they been consumed long time through traditional medicine. Many compounds found plant...
Abstract Dengue viruses (DENVs) are mosquito-borne flaviviruses causing millions of human infections each year and pose a challenge for public health systems worldwide. Aedes aegypti is the principal vector species transmitting DENVs to humans. Controlling Ae. difficult due abundance breeding sites increasing insecticide resistance in populations. Developing new control strategies critical decreasing disease burden. One potential approach genetically replacing populations with highly...
Aedes aegypti is the principal vector of urban arboviruses and blood ingestion important to produce eggs in this species. To analyze egg production Ae. aegypti, researchers frequently use small cages or Drosophila vials collect from gravid females. Although it affordable, setup time- space-consuming, mainly when many mosquitoes need be individually analyzed. This study presents an easy, cheap, space-saving method perform individual oviposition assays using cell culture plates. new access...
the Editors were alerted to concerns regarding interpretation of data and some conclusions.Specific include:-the title does not make it clear that authors only examined genomes specimens lacked transgenes sampled during release period;-the Abstract Introduction use language which is justified given evidence present in peer reviewed literature presented this Article.No sampling for study was conducted more than a few weeks after program, as such there no Article establish whether...
Insect-specific viruses do not replicate in vertebrates. Here, we report the genome sequence of a novel strain Phasi Charoen-like virus (PCLV) that was isolated from wild Aedes aegypti mosquito collected Aracajú, Sergipe State, Brazil. The coding-complete PCLV is described this report.
Zika virus (ZIKV) may cause febrile illness and neurological damage, such as microcephaly in fetuses. ZIKV is transmitted to humans by Aedes aegypti, a nearly cosmopolitan mosquito. Understanding the virus-vector molecular interactions has been promising enhance knowledge towards disease mitigation. Since infection alters gene physiology of mosquitoes, we examined expression profile ZIKV-infected Ae. aegypti several approaches identify genes altered viral infection. Transcriptomics were...
Abstract Since the Zika outbreaks are unprecedented human threat in relation to congenital malformations and neurological/autoimmune complications as well its high potential spread regions presenting vectors, improvements mosquito control is a top priority. Thus, Aedes aegypti laboratory strains will be fundamental support studies different research fields implicated on Zika-mosquito interactions which basis for development of innovative methods. In this sense, we determined main infection...