A5048411014- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Plant biochemistry and biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- Plant Toxicity and Pharmacological Properties
- Molecular spectroscopy and chirality
- Microbial Natural Products and Biosynthesis
- Plant Diversity and Evolution
- Plant-Derived Bioactive Compounds
- Research on Leishmaniasis Studies
- Computational Drug Discovery Methods
- Venomous Animal Envenomation and Studies
- Free Radicals and Antioxidants
- Analytical Chemistry and Chromatography
- Phytochemicals and Antioxidant Activities
- Trypanosoma species research and implications
- Piperaceae Chemical and Biological Studies
- Plant and animal studies
- Phytochemical compounds biological activities
- Phytochemistry Medicinal Plant Applications
- Marine Sponges and Natural Products
- Allelopathy and phytotoxic interactions
- Algal biology and biofuel production
Instituto Butantan
2025
Universidade de São Paulo
2015-2024
Universidade Federal de Pernambuco
2024
Universidade Federal do Pará
2024
Universidade Federal do Oeste do Pará
2024
Instituto de Botânica
2014-2023
Institute of Organic Chemistry with Centre of Phytochemistry
2020
Universidade Estadual Paulista (Unesp)
2020
Centro Universitário da Fundação Educacional de Barretos
2020
Universidade Presbiteriana Mackenzie
2008-2014
During the last decade, knowledge about BBX proteins has greatly increased. Genome-wide studies identified gene family in several ornamental, industry, and food crops; however, reports regarding role of these genes as regulators agronomically important traits are scarce. Here, by phenotyping a knockout mutant, we performed comprehensive functional characterization tomato locus Solyc12g089240, hereafter called SlBBX20. The data revealed encoded protein positive regulator light signaling...
Leishmaniasis and Chagas' are parasitic protozoan diseases that affect the poorest population in world, causing a high mortality morbidity. As result of highly toxic long-term treatments, novel, safe more efficacious drugs essential. In this work, CH2Cl2 phase from MeOH extract leaves Baccharis retusa DC. (Asteraceae) was fractioned to afford two flavonoids: naringenin (1) sakuranetin (2). These compounds were vitro tested against Leishmania spp. promastigotes amastigotes Trypanosoma cruzi...
Resorting to a One Strain Many Compounds (OSMAC) approach, the marine Streptomyces sp. BRB081 strain was grown in six different media settings over 1, 2, 3 or 7 days. Extractions of mycelium and broth were conducted separately for each cultivation period by sonication using methanol/acetone 1:1 agitation with ethyl acetate, respectively. All acetate crude extracts analysed HPLC-MS/MS data treatment performed through GNPS platform MZmine 2 software. In parallel, genome sequenced, assembled...
Background Malignant melanoma is a deadly type of metastatic skin cancer with increased incidence over the past 30 years. Despite advanced knowledge on biology, immunobiology and molecular genetics melanoma, alternatives treatment are limited poor prognosis. On clinical trials, natural products among them redox-active quinones have been tested in attempt to control growth cells. Recently, we isolated jacaranone from Pentacalia desiderabilis, benzoquinone derivative that showed broad...
Duckweeds are the smallest free-floating flowering aquatic plants. Their biotechnological applications include their use as food, bioenergy, and environmental sustainability, they can help clean polluted water. The high growth capacity chemical properties make them suitable for human health applications. Here we evaluated ethanolic extracts from five species of duckweeds by HPLC-DAD/MS-MS characterization. Sixteen compounds were identified quantified, in which three chlorogenic acid...
The essential oils of Piper cernuum and regnellii leaves were analyzed by gas chromatography-mass spectrometry (GC-MS) the results compared to that obtained means a program designed analyse 13C-NMR data complex mixtures. Bicyclogermacrene (21.88 %)/β-caryophyllene (20.69 %) myrcene (52.60 %)/linalool (15.89 major constituents in oil from P. regnellii, respectively. Both presented growth inhibitory activities against Staphylococcus aureus Candida albicans.
The efficiency of the chemiluminescence luminol method and colorimetric DPPH ABTS methods in evaluating antiradical capacity pure compounds plant extracts with antioxidant potential is compared.In case compounds, values parameter 'n' (number radicals quenched per molecule antiradical) for ascorbic acid, p-hydroquinone, catechol, quercetin, rutin are similar when measured by assays; however, considerably lower n obtained assay.The activity from male female individuals Baccharis burchelli...
Premise of research. Although colleters are one the most studied glands Apocynaceae, very little is known regarding composition their secretion. The aim this study was to analyze histochemically vegetative and floral Asclepiadoideae (Apocynaceae) verify function during organ development.Methodology. Shoot apex, leaves, flowers in different developmental stages were processed according usual techniques plant anatomy submitted histochemical tests.Pivotal results. Foliar Peplonia secrete...
Twelve chlorogenic acid derivatives and two flavones were isolated from Moquiniastrum floribundum (Asteraceae, other name: Gochnatia floribunda). Compounds evaluated in relation to their cytotoxicity antiradical properties. Cytotoxicity was not observed for compounds, however, showed activity more active than the Trolox standard. Quinic esterified with caffeoyl group at C-4 position higher compared acylation C-3 or C-5 positions. Additional groups quinic increase 4-caffeoylquinic acid....
Tibouchina pulchra (Cham.) Cogn. is a plant native to Brazil whose genus and family (Melastomataceae) are poorly studied with regards its metabolite profile. Phenolic pigments of pink flowers were by ultra-performance liquid chromatography photodiode array detector electrospray ionization quadrupole time-of-flight mass spectrometry. Therein, twenty-three flavonoids identified eight flavonols isolated preparative high-performance analysed one- two-dimensional nuclear magnetic resonance....
In the search for new bioactive natural products, plant sources represent a particularly suitable starting point in drug discovery. Among phenolic derivatives have prominent place with several compounds exhibiting remarkable activities. This paper described composition of Moquiniastrum floribundum (Asteraceae) and evaluated inhibitory effect isolated on HIV-1 reverse transcriptase. From M. was three flavones, genkwanin (1), hispidulin (2), cirsimaritin (3), eight chlorogenic acid...
Abstract Introduction Casearia is an essential source of cytotoxic highly oxidised clerodane diterpenes, in addition to phenolics, flavonoids, and glycoside derivatives. Here we identify flavonoid‐3‐ O ‐glycoside derivatives the ethyl acetate (EtOAc) fraction methanolic extract from leaves C. arborea leaves. Objective To characterise EtOAc phase using ultra‐high‐performance liquid chromatography diode array detector high‐resolution tandem mass spectrometry (UHPLC‐DAD‐HRMS/MS) molecular...
The Asteraceae, one of the largest families among angiosperms, is chemically characterised by production sesquiterpene lactones (SLs). A total 1,111 SLs, which were extracted from 658 species, 161 genera, 63 subtribes and 15 tribes represented registered in two dimensions SISTEMATX, an in-house software system, associated with their botanical sources. respective 11 block descriptors: Constitutional, Functional groups, BCUT, Atom-centred, 2D autocorrelations, Topological, Geometrical, RDF,...