A5009093749- Natural product bioactivities and synthesis
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Bioactive Compounds
- Ethnobotanical and Medicinal Plants Studies
- Allelopathy and phytotoxic interactions
- Pomegranate: compositions and health benefits
- Phytochemistry and Bioactivity Studies
- Chromatography in Natural Products
- Chemistry Education and Research
- Plant biochemistry and biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
- Synthesis of Organic Compounds
- Science and Education Research
- Education Pedagogy and Practices
- Amphibian and Reptile Biology
- Phytochemical compounds biological activities
- Subterranean biodiversity and taxonomy
- Helicobacter pylori-related gastroenterology studies
- Agricultural and Food Sciences
- Fish biology, ecology, and behavior
Universidade de São Paulo
2007-2024
Weatherford College
2024
Hospital Universitário da Universidade de São Paulo
2022
Universidade Brasil
2013
Universidade Estadual Paulista (Unesp)
2000-2012
Centro Universitário de Araraquara
1998-2009
Hospital de Clínicas da Unicamp
2007
Universidade Estadual de Campinas (UNICAMP)
2003-2007
Instituto de Botânica
2004-2007
The organic pollutants promote significant risks to both human health and environmental sustainability. These compounds have seen a dramatic increase in diversity quantity, infiltrating bodies of water, marine environments, living organisms. Some factors contribute pollutant emissions, such as road traffic industrial activities it leads spatiotemporal variability. Between the pollutants, Trace Organic Contaminants (TrOCs), which comprise diverse range chemicals, pharmaceutical residues,...
Abstract Background Several in vitro studies have looked at the effect of medicinal plant extracts against Helicobacter pylori ( H. ). Regardless popular use Byrsonima crassa B. ) as antiemetic, diuretic, febrifuge, to treat diarrhea, gastritis and ulcers, there is no data on its effects . In this study, we evaluated anti- leaves reactive oxygen/nitrogen intermediates induction by murine peritoneal macrophages. Methods The minimal inhibitory concentration (MIC) was determined broth...
An ethnopharmacological survey indicated that the leaves of Byrsonima intermedia A. Juss. (Malpighiaceae), a medicinal species commonly found in Brazilian Cerrado, can be used against gastroduodenal disorders, such as gastric ulcers and diarrhea.The objective this study was to evaluate effects methanolic extract (MBI) on duodenal assess antimicrobial antidiarrheal extract.The anti-ulcerogenic effect MBI investigated with different ulcerogenic agents rodents (mice rats), including...
Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian "cerrado" (tropical American savanna), and local population uses it to treat diseases, such as diarrhea gastric ulcer. It belongs Malpighiaceae family, commonly known "murici." Considering popular use of B. derivatives lack pharmacological potential studies regarding this vegetal species, mutagenic antimutagenic effect methanol (MeOH) chloroform extracts were evaluated by Ames test, using strains TA97a, TA98,...
Abstract A fast and reliable method, based on high‐performance liquid chromatography coupled to electrospray ionization ion trap tandem mass spectrometry (HPLC/ESI‐ITMS), was developed investigate the infusion prepared from leaves of Byrsonima crassa Niedenzu (Malpighiaceae), a native plant used in Brazil against gastric disorders. The use on‐line reverse‐phase HPLC/ESI‐ITMS allowed separation three major classes compounds identification over 20 very polar characterized as galloylquinic...
We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark Byrsonima crassa. From chloroform extracts leaves, by bioassay-guided fractionation, we mixtures known triterpenes: α-amyrin, β-amyrin their acetates, lupeol, oleanolic acid, ursolic acid α-amyrinone. Tested against Mycobacterium tuberculosis, exhibited minimum inhibitory concentrations (MICs) 31.25 - 312.25 µg/mL. friedelin, isolated extract bark, showed MICs 125 µg/mL respectively. This is first...
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract B. leaves has gastroprotective healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) water (AcoAq), obtained from characterize antiulcer effects these partitions mechanisms action medicinal plant. The on duodenal mucosa were...
Abstract The chemical interaction between plants is known as allelopathy and it related to the release of substances into environment. present study aimed at evaluation allelopathic activity leaves Leonurus sibiricus against germination initial growth Raphanus sativus, Lactuca sativa, Lepidium sativum. Chemical analyses showed presence in four major flavonoids (quercetin-3-O-α-L-rhamnopyranosyl-(1>6)-β-D-galactopyranoside; rutin; hyperin, isoquercetrin) three minor flavonoidic compounds...
Byrsonima species, family Malpighiaceae, is popularly known as "murici". There are several properties attributed to the leaves of species including febrifuge, treat gastrointestinal dysfunctions and skin diseases. In this work, antimicrobial activity fagifolia, B. basiloba intermedia extracts obtained from were evaluated by using disc-diffusion method. The results showed that methanol had presented against all microorganisms tested.
:Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as "jacaranda de espinho" or "espinheira santa nativa" is a medicinal plant commonly used folk medicine to treat ulcers, cough and diarrhea. This study aimed investigate the anti-inflammatory antinociceptive effects of hydroalcoholic extracts from M. twig (HEMh) using vivo experimental models nociception through involvement transient receptor potential channels, acid-sensing ion channel (ASIC), nitrergic, opioidergic,...
Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract enriched alkaloidic fraction (EAF) provided significant protection experimental models wheer used at doses of 250 1000 mg/kg. In vivo tests were carried out evaluate possible toxic effects no mortality observed up 5 g/kg dose level. Phytochemical...
Abstract The isolation of polyphenolic compounds from an infusion the Brazilian plant Davilla elliptica (Dilleniaceae), used as tea by virtue its digestive properties, is described. An improved preparative HPLC method was in order to isolate pure polyphenols complex mixture. Liquid–liquid extraction and solid‐phase were employed minimise interference polymeric provide enriched fraction interest. identification isolated performed using analytical well direct injection electrospray ionisation...
Bioassay-guided fractionation of the chloroform extract Byrsonima fagifolia leaves led to isolation active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 μg mL(-1)), triterpenoids as bassic acid (MIC = 2.5 α-amyrin acetate a mixture lupeol, α- and β-amyrin 31.5 mL(-1)) acetates mL(-1)). The antimycobacterial activity was determined by Microplate Alamar Blue Assay (MABA) structures promising were spectroscopic analysis. This investigation constitutes...
1 The purpose of the present study was to investigate antitumour and anti-inflammatory activities flavonoids isolated from Byrsonima crassa, Davilla elliptica Mouriri pusa. activity measured by MTT assay in murine mammary tumour cells (LM2) IC 50 values fl avonoids tested ranged (31.5 ± 2.97) (203.1 5.9) μg/ml. (myricetin-3-O-α-L-rhamnopyranoside) 3 (quercetin-3-Ogalactopyranoside) D. were most active ones against cells. same samples determine inhibition release nitric oxide (NO) necrosis...
Our taxonomic interest in the Neoraputia stimulated an investigation of N. paraensis searching for alkaloids. Fractions were monitored by ¹H NMR and ESI-MS/MS only those which showed features anthranilate alkaloids flavonoids absent previous investigations examined. Stems afforded flindersine, skimmianine, 8-methoxyflindersine dictamnine; leaves yielded 3',4',7,8-tetramethoxy-5,6-(2",2"-dimethylpyrano)-flavone, 3',4',5,7,8-pentamethoxyflavone, 5-hydroxy-3',4',6,7-tetramethoxyflavone,...