A5024261870- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Helicobacter pylori-related gastroenterology studies
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Blood Coagulation and Thrombosis Mechanisms
- Selenium in Biological Systems
- Pomegranate: compositions and health benefits
- Genomics, phytochemicals, and oxidative stress
- Inflammatory Bowel Disease
- Natural product bioactivities and synthesis
- Ethnobotanical and Medicinal Plants Studies
- Phytochemistry and biological activity of medicinal plants
- Tryptophan and brain disorders
- Flavonoids in Medical Research
- Polysaccharides and Plant Cell Walls
- Herbal Medicine Research Studies
- Heavy Metal Exposure and Toxicity
- Organoselenium and organotellurium chemistry
- Birth, Development, and Health
- Diverse Scientific Research Studies
- Pain Mechanisms and Treatments
- Microbial Metabolites in Food Biotechnology
- Phytochemical Studies and Bioactivities
University of Calgary
2020-2025
Universidade Estadual Paulista (Unesp)
2013-2022
Instituto de Ciências Farmacêuticas
2017
Universidade Federal de Goiás
2017
Universidade Estadual de Campinas (UNICAMP)
2017
Universidade Federal da Paraíba
2017
Morpho (United States)
2017
Biolog (United States)
2017
Mucosal healing is the primary goal for Inflammatory Bowel Diseases (IBD) treatment. We previously showed direct beneficial effects of rhamnogalacturonan (RGal) on intestinal epithelial barrier function. Here, we aimed to evaluate effect RGal in wound healing. Confluent cancer cell lines and colonoid monolayers were wounded, treated with 48 h assessed using a live imaging system. Proliferation apoptosis cells evaluated EdU TUNEL assays, respectively. Antagonists inhibitors used determine...
Chrysin exhibits anti-inflammatory and antioxidant activities. Here, the gastroprotective effect of chrysin was investigated in mouse models gastric ulcer induced by absolute ethanol, acetic acid, ischemia-reperfusion injury. The gastric-healing evaluated at 7 14 days after treatment; mechanism action verified using expression metalloproteinase 2 (MMP-2) 9 (MMP-9), caspase-3, cyclooxygenase 1 (COX-1) (COX-2), epidermal growth factor (EGF), interleukin-10. (10 mg/kg) inhibited macroscopic...
The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions hydroalcoholic extract obtained from leaves Cissus sicyoides (HECS). effect evaluated by oral administration HECS against acute model edema induced xylene, action were analysed involvement arachidonic acid (AA) prostaglandin E₂ (PGE₂). observed we analyzed motility accumulation intestinal fluid. We also evaluating role opioid receptor, α₂ adrenergic muscarinic...
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract B. leaves has gastroprotective healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) water (AcoAq), obtained from characterize antiulcer effects these partitions mechanisms action medicinal plant. The on duodenal mucosa were...
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). The persistent inflammation being mainly attributed to local oxidative stress inflammasome activation implicated in ensuing demyelination axonal damage. Since new control measures remain necessary, we evaluated preventive therapeutic potential a beta-selenium-lactic acid derivative (LAD-βSe), which source organic selenium under development, experimental autoimmune encephalomyelitis (EAE)...
Arrabidaea brachypoda (DC) Bureau is a medicinal plant found in Brazil. Known as "cipó-una", it popularly used natural therapeutic agent against pain and inflammation. This study evaluated the chemical composition antinociceptive activity of dichloromethane fraction from roots A. (DEAB) its mechanism action. The was characterized by high-performance liquid chromatography, this composed only dimeric flavonoids. effect formalin hot plate tests after oral administration (10-100 mg/kg) male...
Terminalia catappa L. (Combretaceae), known as "amendoeira da praia" in Brazil, has been recognized a medicinal plant folk medicine for the treatment of gastrointestinal disorders and other inflammatory conditions. The present study aimed to investigate preventive healing effects infusion leaves T. (ILTC) against gastric lesions caused by ischemia reperfusion (I/R) injury characterize its mechanism action mucosa rats. Different doses (30, 100, 300 mg/kg) ILTC were orally administered acute...
The inflamed mucosa contains a complex assortment of proteases that may participate in wound healing or the development inflammation-associated colon cancer. We sought to determine role protease-activated receptor 2 (PAR2) epithelial both untransformed and transformed colonic cells. Monolayers primary cells derived from organoids cultivated patient biopsies T84 cancer cell line were grown confluence, wounded presence selective PAR2-activating peptide, was visualized by live microscopy....
To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia (HEEP) leaves on gastric ulcer healing.In this rat study involving males, intact (cycling) females, and ovariectomized ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after induction. Body weight monitored throughout treatment period. At end treatment, rats euthanized following in vivo vitro investigations performed: macroscopic examination lesion area...
Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, gastroprotective effects have already been characterized. We evaluated the gastric healing effect of hydroalcoholic extract leaves E. (HEEP) in male female Wistar rats against nonsteroidal anti-inflammatory drugs (NSAIDs) ethanol.The HEEP on mucosa adult...
AIMTo evaluate the anti-inflammatory intestinal effect of ethanolic extract (EtOHE) and hexane phase (HexP) obtained from leaves Combretum duarteanum (Cd ). METHODSInflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute relapsed ulcerative colitis rat models.Damage scores, biochemical, histological immunohistochemical parameters were evaluated. RESULTSBoth Cd -EtOHE -HexP caused significant reductions macroscopic lesion scores areas.The vegetable samples inhibited...
Abstract Background Protease-activated receptors (PARs) and their activating enzymes have been postulated to play a role in inflammatory bowel disease (IBD) pathogenesis, but the specific roles of PAR2 initiation progression remain unclear. activation has both pro-proliferative pro-migratory effects could be involved with restoration epithelial barrier following injury. We previously showed that increases wound healing through ERK, PI3K, JNK pathways. However, Src kinase RhoGTPases, which...