A5023440240- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Gastrointestinal motility and disorders
- Natural product bioactivities and synthesis
- Inflammatory Bowel Disease
- Genomics, phytochemicals, and oxidative stress
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Helicobacter pylori-related gastroenterology studies
- Ginger and Zingiberaceae research
- Phytochemistry and Biological Activities
- Erythrocyte Function and Pathophysiology
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Gastroesophageal reflux and treatments
- Phytochemistry and biological activities of Ficus species
- Infant Health and Development
- Botanical Research and Applications
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Microbial Metabolites in Food Biotechnology
- Phytochemicals and Antioxidant Activities
- Congenital gastrointestinal and neural anomalies
- Plant Toxicity and Pharmacological Properties
- Piperaceae Chemical and Biological Studies
Linköping University
2020-2025
Universidade Estadual de Campinas (UNICAMP)
2011-2020
Universidade Estadual Paulista (Unesp)
2017
Instituto de Ciências Farmacêuticas
2017
Universidade Federal de Goiás
2017
Universidade Federal da Paraíba
2017
Morpho (United States)
2017
Biolog (United States)
2017
University of California, Los Angeles
2016
The aim of this research was to investigate the anti-apoptotic, antioxidant and anti-inflammatory properties menthol against ethanol-induced gastric ulcers in rats. Wistar rats were orally treated with vehicle, carbenoxolone (100 mg/kg) or (50 then ethanol induce ulcers. After euthanasia, stomach samples prepared for histological slides biochemical analyses. Immunohistochemical analyses cytoprotective anti-apoptotic heat-shock protein-70 (HSP-70) apoptotic Bax protein performed. neutrophils...
To evaluate the antioxidant activity of essential oil obtained from Rosmarinus officinalis (R. officinalis) in ethanol-induced gastric ulcer model vivo. The properties R. were evaluated against injury induced by absolute ethanol. Gastric tissues prepared to enzymatic assays. levels glutathione, lipid peroxides, and activities glutathione peroxidase, superoxide dismutase myeloperoxidase measured. Ethanol produced severe hemorrhagic lesions stomach with ulcerative lesion (140.2 ± 37.2) mm2. In...
BRAF inhibitors are highly effective therapies for the treatment of BRAF(V600)-mutated melanoma, with main toxicity being a variety hyperproliferative skin conditions due to paradoxical activation mitogen-activated protein kinase (MAPK) pathway in wild-type cells. Most these changes improve when MEK inhibitor is co-administered, as it blocks MAPK activation. Here we show how vemurafenib accelerates wound healing by inducing proliferation and migration human keratinocytes through...
Abstract Background Inflammatory bowel disease (IBD) is a complex and recurring inflammatory disorder that affects the gastrointestinal tract.1 Various drugs have been developed for treating IBD, but there are still limitations due to adverse effects experienced by patients.2 Plant-derived molecules with anti-inflammatory properties represent valuable alternative as complementary therapy IBD.3 Isatin compound found in several medicinal plant species various biological activities, including...
Primary afferent neurons that convey somatosensory modalities comprise two large, heterogeneous populations: small-diameter give rise to slowly conducting unmyelinated axonal C fibers and medium-to-large diameter with fast myelinated A fibers. Despite these major groupings, tools differentiate between primary by genetic targeting have not been available; in particular, whereas numerous mouse driver lines exist target different fiber populations, populations are scarce. Here we describe a...
Spinal nociceptive withdrawal reflexes are widely believed to rely on unmyelinated and thinly myelinated fibers that also signal affective motivational aspects of pain. Here we discover a population mechanoreceptive nociceptor forms free nerve endings as well circumferential around hair follicles, exclusively terminate in the deep spinal dorsal horn. Optogenetic activation these triggers rapid precise selective for targeted limb, while silencing increases threshold mechanical reflexes. By...
Abstract Primary afferent neurons that convey somatosensory modalities comprise two large, heterogeneous populations: small-diameter give rise to slowly conducting unmyelinated axonal C fibers and medium-to-large diameter with fast myelinated A fibers. Despite these major groupings, tools differentiate between primary by genetic targeting have not been available; in particular, whereas numerous mouse driver lines exist target different fiber populations, populations are scarce. Here we...
Human and mouse studies have shown that rotavirus infection is associated with low inflammation unaffected intestinal barrier at the time of diarrhea, properties different from most bacterial inflammatory diseases gut. We showed by in vitro , ex vivo experiments neurotrophic factors 5-HT protective during insult. These observations advance our understanding how gut protected against suggest affects differently bacteria. This first report to show contribute maintain epithelial viral
Rhizophora mangle, the red mangrove, has long been known as a traditional antiulcer medicine. The present work evaluated mechanisms of action involved in anti-ulcer properties mangle bark extracts. Gastroprotection was rodent experimental models (ethanol). To elucidate antisecretory and involvement NO, SH, mucus PGE2 were evaluated. acetic acid-induced gastric ulcer model, Western blotting assay (COX-1, COX-2 EGF) immunohistochemical localization HSP-70, PCNA also used to evaluate healing...
Enteric glial cells (EGC) are known to regulate gastrointestinal functions; however, their role in Crohn’s disease (CD) is elusive. Microscopic erosions over the ileal Peyer’s patches early signs of CD. The aim this work was assess localization EGC follicle and interfollicular region lamina propria study effects mediators on barrier function CD patients non-inflammatory bowel (non-IBD) controls. markers, fibrillary acidic protein (GFAP), S100 calcium-binding β (S100β) were quantified by...
Peptic ulcers are a common disorder of the entire gastrointestinal tract, its etiology has not been completely elucidated. The basic physiopathological peptic result from an imbalance between some endogenous aggressive factor and cytoprotective factors. treatment this disease is usually done with antacids or proton pump, but currently being used plants derivated compounds. We evaluated gastroprotective properties possible mechanisms action essential oil Protium heptaphyllum (Aubl.) Marchand,...
Rhizophora mangle , the red mangrove, has long been known as a traditional medicine. Its bark used astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate antioxidant properties of buthanolic fraction R. extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment after induction injury absolute ethanol ischemia-reperfusion. Gastric tissues from both methods were prepared enzymatic assays, levels...
Abstract Background Enteric glial cells (EGC) and mast (MC) are intimately associated with gastrointestinal physiological functions. We aimed to investigate EGC‐MC interaction in irritable bowel syndrome (IBS), a gut‐brain disorder linked increased intestinal permeability, MC. Methods Parallel approaches were used quantify EGC markers colonic biopsies from healthy controls (HC) patients IBS. Data correlated MC, vasoactive polypeptide (VIP) VIP receptors (VPAC1/VPAC2) expressions, bacterial...
Irritable bowel syndrome (IBS) is a gut-brain disorder associated with increased gut permeability. Zonulin has been suggested to regulate the barrier and claimed be pre-haptoglobin 2 (pre-HP2) circulating zonulin often used as proxy for gastrointestinal This study investigated correlation between colonic paracellular permeability levels of pre-HP2.Colonic biopsies from 32 patients IBS 15 healthy controls (HC) were measure in Ussing chambers (Cusabio ELISA). was also measured blood samples 40...
The genus Hyptis comprehends almost 400 species widespread in tropical and temperate regions of America. use spicigera Lam. (Lamiaceae) is reported traditional medicine due to its gastroprotective, anti-inflammatory analgesic properties.The rationale this study was investigate the potential essential oil H. (EOHs) as analgesic.The antinociceptive effect EOHs verified analyzing acute nocifensive behavior mice induced by chemical noxious stimuli [i.e., formalin transient receptor (TRP)...
The mechanism underlying the role of tumor necrosis factor alpha (TNF-α) in development inflammatory hyperalgesia has been extensively studied, mainly TNF-α release pro-inflammatory cytokines. current concept relies fact that stimulates cascade other cytokines, such as IL-1β, IL-6, and IL-8 (CINC-1 rats), triggering final mediator prostaglandin E2 (PGE2 ) sympathetic amines directly sensitize nociceptors. However, this may not be sole involved blockade synthesis by thalidomide prevents...
Abarema cochliacarpos (Gomes) Barneby & Grimes (Mimosaceae) is a species--in folk medicine of Lagarto city, Sergipe state, northeastern Brazil--reputed to heal gastric ulcer and gastritis.Chloroform (CE) methanolic (ME) extracts as well ethyl acetate fraction (AF), butanolic (AC) aqueous (AQF) the extract bark were evaluated against acute ulcer. The AC was selected assess its activity in healing gastroprotective effects via mucus secretion.The action CE ME fractions latter rodent...
Male Unib-WH rats were pretreated for two weeks with butanolic (BuOH) and ethyl acetate (EtOAc) fractions. Colitis was induced by rectal administration of TNBS, the treatment continued, animals sacrificed on day 7 after TNBS administration. Phytochemical studies performed in order to provide characterization tannins present bark R. mangle. Results showed that EtOAc fraction increased levels IL-10 (∗∗P < 0.01) diminished TNF-α (∗∗∗P 0.001) IL-6 0.01). BuOH reduced MPO activity TBARS 0.001);...
This study evaluated the possible protective effects of cilostazol against myonecrosis in dystrophic diaphragm muscle vivo, focusing on oxidative stress, inflammatory response and angiogenesis. Young mdx mice, experimental animal for Duchenne muscular dystrophy, received 14 days. A second group mice a control C57BL/10 saline solution. In treatment was associated with reduced loss strength (-34.4%), decreased myonecrosis, creatine kinase levels (-63.3%) fibres stained immunoglobulin G...
Several species of Bauhinia are used in traditional medicine for the treatment gastrointestinal diseases, diabetes, and inflammation, among other conditions. The aim this study was to investigate antiulcer effect a hydroalcoholic extract from leaves B. holophylla . chemical profile determined by HPLC-PAD-ESI-IT-MS. A dose-effect relation constructed using ethanol-induced gastric ulcer model male Wistar rats. Histological analyses studies antioxidant anti-inflammatory activities were...