A5056604340- Helicobacter pylori-related gastroenterology studies
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Inflammatory Bowel Disease
- Ginger and Zingiberaceae research
- Phytochemistry and Bioactive Compounds
- Phytochemistry and Biological Activities
- Phytochemical Studies and Bioactivities
- Phytochemicals and Antioxidant Activities
- Papaya Research and Applications
- Microscopic Colitis
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Advances in Cucurbitaceae Research
- Ginkgo biloba and Cashew Applications
- Bee Products Chemical Analysis
- Plant Toxicity and Pharmacological Properties
- Microbial Metabolites in Food Biotechnology
- Phytochemistry and biological activities of Ficus species
- Plant-derived Lignans Synthesis and Bioactivity
- Education Pedagogy and Practices
- Morinda citrifolia extract uses
- Cynara cardunculus studies
- Cell death mechanisms and regulation
Universidade Federal de Catalão
2021-2024
Universidade Estadual de Londrina
2024
Universidade Federal de Goiás
2012-2019
Universidade Estadual de Campinas (UNICAMP)
2008-2017
Universidade Estadual Paulista (Unesp)
2017
Instituto de Ciências Farmacêuticas
2017
Universidade Federal da Paraíba
2017
Morpho (United States)
2017
Czech Academy of Sciences, Institute of Biotechnology
2017
Biolog (United States)
2017
The bioactive compounds of freeze-dried jaboticaba peel (FJP), serum lipids and the antioxidant status rats fed high-fat diets containing different doses FJP were evaluated. Obesity was induced three groups obese animals received diet with 1%, 2% 4% added (J1, J2 J4, respectively). HPLC–DAD analyses polyphenols in showed four compounds: gallic acid, cyanidin 3-glucoside, ellagic quercetin. saturated fatty acids reduced J1 J4-fed animals. defenses plasma increased All prevented lipid...
To evaluate the antioxidant activity of essential oil obtained from Rosmarinus officinalis (R. officinalis) in ethanol-induced gastric ulcer model vivo. The properties R. were evaluated against injury induced by absolute ethanol. Gastric tissues prepared to enzymatic assays. levels glutathione, lipid peroxides, and activities glutathione peroxidase, superoxide dismutase myeloperoxidase measured. Ethanol produced severe hemorrhagic lesions stomach with ulcerative lesion (140.2 ± 37.2) mm2. In...
In Brazilian traditional medicine, Arctium lappa (Asteraceae), has been reported to relieve gastrointestinal symptoms.In the present study, we investigated effects of lactone sesquiterpene onopordopicrin enriched fraction (ONP fraction) from in an experimental colitis model induced by 2,4,6 trinitrobenzene sulfonic acid and performed experiments elucidate underlying action mechanisms involved that effect.ONP (25 50 mg/kg/day) was orally administered 48, 24 1 h prior induction after. The...
This study aimed to demonstrate the importance of active carbapenem-resistant Enterobacterales (CRE) surveillance and evaluate prevalence invasive infections, risk factors, mortality in CRE-colonized patients.Retrospective cohort analyzing 1,920 patients identified using an CRE protocol, admitted adult intensive care unit southeastern Brazil from January 2014 December 2018.There were 297 (15.47%) colonized patients, with one for every six control patients. demonstrated increased chance...
Inflammatory bowel disease is a chronic relapsing that affects millions of people worldwide; its pathogenesis influenced by genetic, environmental, microbiological, and immunological factors. The aim this study was to evaluate the effects short- long-term Passiflora edulis peel intake on antioxidant status, microbiota, short-chain fatty acids formation in rats with 2,4,6-trinitrobenzenesulphonic acid-induced colitis using two "in vivo" experiments: (prevention) acute (treatment). damage...
Abstract Background Inflammatory bowel disease (IBD) is a complex and recurring inflammatory disorder that affects the gastrointestinal tract.1 Various drugs have been developed for treating IBD, but there are still limitations due to adverse effects experienced by patients.2 Plant-derived molecules with anti-inflammatory properties represent valuable alternative as complementary therapy IBD.3 Isatin compound found in several medicinal plant species various biological activities, including...
Leaves and bark infusions Anacardium humile St. Hil. (Anacardiaceae), known as in Brazil “cajuzinho do cerrado”, have been used folk medicine an alternative treatment for ulcers gastritis. This study evaluated the gastroprotective activity of ethyl acetate extract leaves A. (AcF) mechanism involved this gastroprotection. Pretreatment concentrations (50, 100, 200 mg.kg−1) were administered by gavage. Following a 60 min. period, all rats orally 1 mL absolute ethanol. One hour after...
Rhizophora mangle, the red mangrove, has long been known as a traditional antiulcer medicine. The present work evaluated mechanisms of action involved in anti-ulcer properties mangle bark extracts. Gastroprotection was rodent experimental models (ethanol). To elucidate antisecretory and involvement NO, SH, mucus PGE2 were evaluated. acetic acid-induced gastric ulcer model, Western blotting assay (COX-1, COX-2 EGF) immunohistochemical localization HSP-70, PCNA also used to evaluate healing...
Ethanol-induced oxidative damage is commonly associated with the generation of reactive oxygen molecules, leading to stress. Considering that antioxidant activity an important mechanism action involved in cytoprotection, aim this work was evaluate properties alkaloid indigo (1) (2 mg/kg, P. O.), obtained from leaves Indigofera truxillensis Kunth (Fabaceae), on rat gastric mucosa submitted ethanol-induced (100%, 1 mL, O.) ulcer. Enzymatic assays and DNA fragmentation analysis were performed....
Rhizophora mangle , the red mangrove, has long been known as a traditional medicine. Its bark used astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate antioxidant properties of buthanolic fraction R. extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment after induction injury absolute ethanol ischemia-reperfusion. Gastric tissues from both methods were prepared enzymatic assays, levels...
Peptic ulcers are a common disorder of the entire gastrointestinal tract, its etiology has not been completely elucidated. The basic physiopathological peptic result from an imbalance between some endogenous aggressive factor and cytoprotective factors. treatment this disease is usually done with antacids or proton pump, but currently being used plants derivated compounds. We evaluated gastroprotective properties possible mechanisms action essential oil Protium heptaphyllum (Aubl.) Marchand,...
Arctium lappa L. has been used in folk medicine as a diuretic, depurative, and digestive stimulant dermatological conditions. The mechanisms involved the anti-ulcerogenic activity of sesquiterpene onopordopicrin (ONP)-enriched fraction (termed ONP fraction), obtained from A. leaves, were studied. gastroprotective mechanism was evaluated experimental vivo models rodents, mimicking this disease humans. (50 mg/kg, p.o.) significantly inhibited mucosal injury induced by ethanol/HCl solution...
Abarema cochliacarpos (Gomes) Barneby & Grimes (Mimosaceae) is a species--in folk medicine of Lagarto city, Sergipe state, northeastern Brazil--reputed to heal gastric ulcer and gastritis.Chloroform (CE) methanolic (ME) extracts as well ethyl acetate fraction (AF), butanolic (AC) aqueous (AQF) the extract bark were evaluated against acute ulcer. The AC was selected assess its activity in healing gastroprotective effects via mucus secretion.The action CE ME fractions latter rodent...