A5033558198- Phytochemicals and Antioxidant Activities
- Agricultural and Food Sciences
- Antioxidant Activity and Oxidative Stress
- Natural Antidiabetic Agents Studies
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Essential Oils and Antimicrobial Activity
- Medicinal Plants and Neuroprotection
- Medicinal Plant Extracts Effects
- Biochemical Analysis and Sensing Techniques
- Sensory Analysis and Statistical Methods
- Pharmacology and Obesity Treatment
- Consumer Attitudes and Food Labeling
- Phytochemistry Medicinal Plant Applications
- Food composition and properties
- Plant Physiology and Cultivation Studies
- Regulation of Appetite and Obesity
- Peanut Plant Research Studies
- Science and Education Research
- Diet, Metabolism, and Disease
- Nanoparticle-Based Drug Delivery
- Healthcare during COVID-19 Pandemic
- Complementary and Alternative Medicine Studies
- Fermentation and Sensory Analysis
- Graphene and Nanomaterials Applications
Universidade Federal de Santa Maria
2018-2024
Universidade Federal de Juiz de Fora
2022-2024
Universidade Estadual de Campinas (UNICAMP)
2012-2021
Lund University
2016-2019
Universidade Federal dos Vales do Jequitinhonha e Mucuri
2010-2013
This paper reports on the anthocyanin and antioxidant contents, an 'in vitro' antiproliferative vivo' mutagenic/antimutagenic activities of freeze-dried jaboticaba peel (JP). According to proximate composition, JP showed a high dietary fiber content. The identification quantification anthocyanins was carried out by HPLC-PDA LC–MS/MS, which revealed presence two compounds: delphinidin 3-glucoside cyanidin (634.75 1963.57 mg 100 g− 1 d. w., respectively). strong potential: 25,514.24 ± 3037 μM...
Passion fruit (Passiflora edulis), including its leaves, is a rich source of bioactive compounds, as polyphenols. This study investigated the in vitro and vivo antioxidant potential aqueous extract P. edulis leaves identification phenolic compounds by HPLC-PDA ESI-MS/MS analysis. Male Wistar rats were divided two groups (n = 6 per group). Control group received water experimental leaf (Tea) (1.1 mg dry mL− 1), both ad libitum. Total phenols (DPPH, FRAP, ABTS ORAC assay) determined extract....
The bioactive compounds of freeze-dried jaboticaba peel (FJP), serum lipids and the antioxidant status rats fed high-fat diets containing different doses FJP were evaluated. Obesity was induced three groups obese animals received diet with 1%, 2% 4% added (J1, J2 J4, respectively). HPLC–DAD analyses polyphenols in showed four compounds: gallic acid, cyanidin 3-glucoside, ellagic quercetin. saturated fatty acids reduced J1 J4-fed animals. defenses plasma increased All prevented lipid...
Jaboticaba (Myrciaria spp.) is a Brazilian fruit with high concentrations of anthocyanins in the peel which have shown antioxidant effects and possible benefits on obesity insulin resistance. The objective this study was to evaluate effect freeze-dried jaboticaba (FJP) added high-fat diet development Sprague–Dawley rats were fed control diet, (HF) HF diets 1, 2 4% FJP. Energy intake, weight gain, body composition, serum glucose, lipid hormonal profiles determined. Glucose tolerance,...
Polyethylene glycol (PEG) coating has been frequently used to improve the pharmacokinetic behavior of nanoparticles. Studies that contribute better unravel effects PEGylation on toxicity nanoparticle formulation are therefore highly relevant. In present study, reduced graphene oxide (rGO) was functionalized with PEG, and its key components blood-brain barrier, such as astrocytes endothelial cells, were analyzed in culture an vivo rat model. The vitro studies demonstrated...
We have previously demonstrated that reduced graphene oxide (rGO) administered intravenously in rats was detected inside the hippocampus after downregulation of tight and adherens junction proteins blood-brain barrier. While down-regulators junctional could be useful tools for drug delivery through paracellular pathway, concerns over toxicity must investigated before clinical application. Herein, our purpose to trace whether rGO triggered toxic alterations this brain region target organs...
Copaifera langsdorffii (copaiba) is a Brazilian exotic fruit, poorly studied regarding its bioactive composition. The aim of this study was to determine compounds, antioxidant and antimutagenic activities copaiba pulp. samples were extracted with different solvents in order analyze polyphenol compounds (Folin Ciocalteau HPLC–DAD), total flavonoids (reaction AlCl3) capacity (FRAP, ORAC, DPPH). fruit showed high content capacity. Phenolic such as gallic acid, epicatechin gallate, catechin,...
Abstract The hyperphosphorylation of microtubule‐associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance these alterations are related to development tauopathies, such as Alzheimer's disease. In this study, we used a high‐fat diet induce obesity adult Swiss mice checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve sensitivity, learning/memory performance, prevent phosphorylation hippocampus....
The antioxidant and anti-inflammatory effects of the aqueous extract Passiflora edulis leaves, which is a source vitexin, isovitexin isoorientin, was investigated in 2,4,6-trinitrobenzenesulphonic acid induced colitis model. oral intake P. (1100 µg mL−1) improved significantly (P < 0.05) endogenous status decreased lipid peroxidation serum, liver, colon. consumption level pro-inflammatory colon tissue, especially by reducing IL-1β five-fold TNF-α two-fold compared to control group. leaves...
Food biodiversity is vital for human health and sustainable food systems. However, research on neglected underutilized species limited by funding, uneven capacity, the challenge of balancing ecological, cultural, public considerations, requiring innovative prioritization approaches. Using Brazil as a model, this study inventories 369 across algae, aquatic fauna, wild terrestrial vertebrates, insects, mushrooms, plants. A mixed-methods approach, combining expert knowledge explainable AI...
Inflammatory bowel disease is a chronic relapsing that affects millions of people worldwide; its pathogenesis influenced by genetic, environmental, microbiological, and immunological factors. The aim this study was to evaluate the effects short- long-term Passiflora edulis peel intake on antioxidant status, microbiota, short-chain fatty acids formation in rats with 2,4,6-trinitrobenzenesulphonic acid-induced colitis using two "in vivo" experiments: (prevention) acute (treatment). damage...
Abstract BACKGROUND Grape juice consumption may prevent several chronic diseases owing to the presence of phenolic compounds, which have an important role in reduction oxidative stress. This study investigated polyphenol content and antioxidant activities grape juices from two cultivars: BRS ‐Cora Isabella. Total ( TPC ), anthocyanins, capacity (oxygen radical absorbance capacity, ferric reducing power 1,1‐diphenyl‐2‐picrylhydrazyl), profile (high‐performance liquid chromatography with diode...
Natural compounds could be a complementary alternative to inflammatory bowel disease (IBD) management. This study determined the effects of an aqueous extract Myrciaria jaboticaba peel (EJP) (50 g L-1) on 2,4,6-trinitrobenzenesulfonic acid-induced colitis. Wistar rats were randomized into five groups: HC-healthy control, CC-colitis DC-drug SJ-short-term treatment with EJP, and LJ-long-term EJP. The EJP treatments reduced body weight loss, stool consistency score, spleen enlargement. Gut...
Resumo Com a mudança na alimentação dos adultos nas últimas décadas, aumenta o desenvolvimento de doenças crônicas não transmissíveis. Aumentar consumo alimentos funcionais, com ações metabólicas benéficas ao organismo, é uma estratégia para proporcionar benefícios à saúde em longo prazo. O objetivo deste trabalho foi identificar os fatores que têm influência percepção e no funcionais por adultos. Neste estudo, dentre interferem identificados, aspectos socioeconômicos, qualidade se...
Passion fruit (Passiflora edulis) is a native species from Brazil explored in culture. Peels are byproducts of juice industrial processing and usually discarded. They source fibers other bioactive substances, which may have antioxidant role to protect cells against oxidative stress. This study aimed evaluate the status P. edulis peel flour vivo. The male Wistar rats (77 days old) were divided Peel Control groups (n = 4). group was fed with standard diet (AIN-93M) group, received fifty...
In this study, we supplemented a high-fat diet (HF) with 5% powder of freeze-dried Syzygium malaccense fruit (HS) and investigated proofs peripheral insulin resistance, hippocampal AKT–GSK3-β–tau activation, learning/memory performance, brain frontal lobe oxidative stress. The intake HS did not prevent weight gain but promoted sensitivity, improved AKT signaling in the hippocampus, which prevented activation GSK3-β lowered tau phosphorylation induced HF. results from Morris water maze...